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In vitro activity of celastrol in combination with thymol against carbapenem-resistant Klebsiella pneumoniae isolates
Klebsiella pneumoniae is an opportunistic pathogen causing nosocomial and community-acquired infections. Klebsiella has developed resistance against...
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Chemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis
BackgroundMalaria remains a global health burden, and the emergence and increasing spread of drug resistance to current antimalarials poses a major...
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Celastrol mitigates staphyloxanthin biosynthesis and biofilm formation in Staphylococcus aureus via targeting key regulators of virulence; in vitro and in vivo approach
BackgroundStaphylococcus aureus is a leading cause of human infections. The spread of antibiotic-resistant staphylococci has driven the search for...
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The Protective Role of Celastrol in Renal Ischemia-Reperfusion Injury by Activating Nrf2/HO-1, PI3K/AKT Signaling Pathways, Modulating NF-κb Signaling Pathways, and Inhibiting ERK Phosphorylation
Celastrol, a natural triterpenoid derived from Tripterygium wilfordii, possesses numerous biological effects. We investigated celastrol’s antioxidant...
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Enhancement of Celastrol compound by silver nanoparticles and acetosyringone in Celastrus paniculatus Willd. through adventitious and hairy root culture
Celastrus paniculatus Willd., an important medicinal plant for the treatment of neurodegenerative diseases is at risk of extinction due to...
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Spatial transcriptomics analysis of zone-dependent hepatic ischemia-reperfusion injury murine model
Hepatic ischemia-reperfusion (I/R) injury is a common complication in liver transplantation. The connection between I/R-induced injury response and...
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Celastrol attenuates ox-LDL-induced mesangial cell proliferation via suppressing NLRP3 inflammasome activation
Mesangial cell (MC) proliferation is one of the important pathological features of obesity-associated nephropathy with unknown etiology. Excessive MC...
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Root cultures of Monteverdia floribunda (Reissek) Biral grown in air sparging systems are sources of quinonemethide triterpenes
Quinonemethide triterpenes (QMTs) are chemotaxonomic markers of the family Celastraceae that are known to possess anti-inflammatory, antioxidant and...
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Immunomodulatory properties of triterpenes
The immune system is one of the main defence mechanisms of the human body. Inadequacy of this system or immunodeficiency results in increased risk of...
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Plant-Derived Compounds with Therapeutic Potential for the Treatment of Human Coronavirus Diseases
Since the advent of modern civilization, few diseases have caused more worldwide socioeconomic disruptions than COVID-19 caused by severe acute...
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Therapeutic Effects and Related Molecular Mechanisms of Celastrol, a Triterpenoid Natural Compound and Novel HSP90 Inhibitor Extracted from Plants of the Celastraceae Family
Celastrol, a triterpenoid compound first identified in the Chinese herbal Tripterygium Wilfordii Hook, f. (TWHF), has attracted much attention in...
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CIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer
Tumor cells are usually considered defective in mitochondrial respiration, but human non-small cell lung cancer (NSCLC) tumor tissues are shown to...
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Thermal Shift Assay in Ferroptosis
Ferroptosis is a recently described process of cell death that is dependent on unregulated cellular iron accumulation with induction of oxidative...
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Pyroptosis in neurodegenerative diseases: from bench to bedside
The central nervous system regulates all aspects of physiology to some extent. Neurodegenerative diseases (NDDs) lead to the progressive loss and...
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Celastrol alleviates renal fibrosis by upregulating cannabinoid receptor 2 expression
Renal fibrosis is the final manifestation of various chronic kidney diseases, and no effective therapy is available to prevent or reverse it....
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DendroX: multi-level multi-cluster selection in dendrograms
BackgroundCluster heatmaps are widely used in biology and other fields to uncover clustering patterns in data matrices. Most cluster heatmap packages...
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Repurposing proteasome inhibitors for improved treatment of triple-negative breast cancer
Triple-negative breast cancer (TNBC) is associated with poor prognosis and limited treatment options due to the lack of important receptors (estrogen...
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SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging
Fibrosis is a typical aging-related pathological process involving almost all organs, including the heart, kidney, liver, lung, and skin....
