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Structural determinants for activation of the Tau kinase CDK5 by the serotonin receptor 5-HT7R
BackgroundMultiple neurodegenerative diseases are induced by the formation and deposition of protein aggregates. In particular, the...
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Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition
BackgroundActivated Cdk5 regulates a number of processes during nervous system formation, including neuronal differentiation, growth cone...
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Cdk5 regulates IP3R1-mediated Ca2+ dynamics and Ca2+-mediated cell proliferation
Loss of cyclin-dependent kinase 5 (Cdk5) in the mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) increases ER–mitochondria...
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MiR-26a regulated adipogenic differentiation of ADSCs induced by insulin through CDK5/FOXC2 pathway
Objective: Obesity is associated with an increased risk of develo** insulin resistance and type 2 diabetes, since insulin can induce adipogenic...
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Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy
Radiation-induced optic neuropathy (RION) is a devastating complication following external beam radiation therapy (EBRT) that leads to acute vision...
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Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases
Ubiquitin modifications alter protein function and stability, thereby regulating cell homeostasis and viability, particularly under stress. Ischemic...
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Preso enhances mGluR1-mediated excitotoxicity by modulating the phosphorylation of mGluR1-Homer1 complex and facilitating an ER stress after traumatic brain injury
Glutamate receptor (GluR)-mediated excitotoxicity is an important mechanism causing delayed neuronal injury after traumatic brain injury (TBI)....
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CRISPR-based gene expression platform for precise regulation of bladder cancer
The development of compact CRISPR systems has facilitated delivery but has concurrently reduced gene editing efficiency, thereby limiting the further...
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Deciphering the multi-functional role of Indian propolis for the management of Alzheimer’s disease by integrating LC–MS/MS, network pharmacology, molecular docking, and in-vitro studies
The conventional one-drug-one-disease theory has lost its sheen in multigenic diseases such as Alzheimer’s disease (AD). Propolis, a honeybee-derived...
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An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation
BackgroundSemaphorins (Sema) belong to a large family of repellent guidance cues instrumental in guiding axons during development. In particular,...
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Whole transcriptome map** reveals the lncRNA regulatory network of TFP5 treatment in diabetic nephropathy
BackgroundTFP5 is a Cdk5 inhibitor peptide, which could restore insulin production. However, the role of TFP5 in diabetic nephropathy (DN) is still...
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Site-specific phosphorylation of Fbxw7 by Cdk5/p25 and its resulting decreased stability are linked to glutamate-induced excitotoxicity
Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine protein kinase that regulates brain development and neurodegeneration. Cdk5 is activated by...
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CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer’s disease
Alzheimer’s disease (AD) is the most common form of neurodegenerative disease featured with memory loss and cognitive function impairments. Chronic...
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LncRNA TTN-AS1 promotes migration, invasion, and epithelial mesenchymal transition of lung adenocarcinoma via sponging miR-142-5p to regulate CDK5
Emerging evidence suggests that long noncoding RNA (lncRNA) plays pivotal roles in regulating various biological process in human cancers....
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Alteration of gene expression in reactive astrocytes induced by Aβ1-42 using low dose of methamphetamine
BackgroundAlzheimer's disease (AD) is a degenerative brain disorder. Due to the relationship between the functional loss of astrocytes and AD, the...
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Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke
CDK5 activation promotes ischemic neuronal death in stroke, with the recognized activation mechanism being calpain-dependent p35 cleavage to p25....
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RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation
Tauopathies are a group of neurodegenerative diseases characterized by hyperphosphorylation of the microtubule-binding protein, tau, and typically...
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In silico analysis of the possible crosstalk between O-linked β-GlcNAcylation and phosphorylation sites of Disabled 1 adaptor protein in vertebrates
Disabled 1 (Dab1) is an adaptor protein with essential functions regulated by reelin signaling and affects many biological processes in the nervous...
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Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth
Amino acid homeostasis is critical for many cellular processes. It is well established that amino acids are compartmentalized using pH gradients...
