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Casein kinase 2 phosphorylates and induces the SALL2 tumor suppressor degradation in colon cancer cells
Spalt-like proteins are Zinc finger transcription factors from Caenorhabditis elegans to vertebrates, with critical roles in development. In...
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Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer’s disease
Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder. Increased Aβ production plays a fundamental role in the...
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Oocyte Casein kinase 1α deletion causes defects in primordial follicle formation and oocyte loss by impairing oocyte meiosis and enhancing autophagy in develo** mouse ovary
Casein kinase 1α is a member of CK1 family, which is ubiquitously expressed and plays multiple functions, including its potential roles in regulating...
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The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis
Casein kinase 2 (CK2) is a pleiotropic kinase phosphorylating substrates in different cellular compartments in eukaryotes. In the malaria parasite Plas...
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A resource database for protein kinase substrate sequence-preference motifs based on large-scale mass spectrometry data
BackgroundProtein phosphorylation is one of the most prevalent posttranslational modifications involved in molecular control of cellular processes,...
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TNF-α-induced down-regulation of type I interferon receptor contributes to acquired resistance of cervical squamous cancer to Cisplatin
We aimed to investigate the effects of tumor necrosis factor (TNF)-α on the expression of interferon α/β receptor subunit 1 (IFNAR1) and cervical...
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Protein kinase CK2 – diverse roles in cancer cell biology and therapeutic promise
The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and proliferation in cells was apparent at early stages of...
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Regulation of SNARE assembly by protein phosphorylation
Protein phosphorylation is emerging as an important regulatory mechanism that controls the secretory pathway. It enables coupling between the...
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Inositol hexakisphosphate primes syndapin I/PACSIN 1 activation in endocytosis
Endocytosis is controlled by a well-orchestrated molecular machinery, where the individual players as well as their precise interactions are not...
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Phototropin2 3’UTR overlaps with the AT5G58150 gene encoding an inactive RLK kinase
BackgroundThis study examines the biological implications of an overlap between two sequences in the Arabidopsis genome, the 3’UTR of the PHOT2 gene...
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LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner
Mutations in the leucine-rich repeat kinase 2 ( LRRK2 ) gene are the most common genetic cause of Parkinson’s disease (PD), with growing importance...
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Casein kinase 2 modulates the spindle assembly checkpoint to orchestrate porcine oocyte meiotic progression
BackgroundCK2 (casein kinase 2) is a serine/threonine-selective protein kinase that has been involved in a variety of cellular processes such as DNA...
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Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase Mer
The receptor tyrosine kinase Mer (gene name Mertk ) acts in vascular endothelial cells (ECs) to tighten the blood-brain barrier (BBB) subsequent to...
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VRK1 promotes DNA-induced type I interferon production
BackgroundType I interferons (IFNs) are an essential class of cytokines with antitumor, antiviral and immunoregulatory effects. However,...
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LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity
BackgroundNeutrophils depend heavily on glycolysis for energy production under normal conditions. In contrast, neutrophils require energy supplied by...
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Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3
Upon necroptosis activation, receptor interacting serine/threonine kinase (RIPK)1 and RIPK3 form a necrosome complex with pseudokinase mixed lineage...
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20-Hydroxyecdysone counteracts insulin to promote programmed cell death by modifying phosphoglycerate kinase 1
BackgroundThe regulation of glycolysis and autophagy during feeding and metamorphosis in holometabolous insects is a complex process that is not yet...
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Tumour-specific phosphorylation of serine 419 drives alpha-enolase (ENO1) nuclear export in triple negative breast cancer progression
BackgroundThe glycolytic enzyme alpha-enolase is a known biomarker of many cancers and involved in tumorigenic functions unrelated to its key role in...
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Salt-inducible kinases inhibitor HG-9-91-01 targets RIPK3 kinase activity to alleviate necroptosis-mediated inflammatory injury
Receptor-interacting protein kinase 3 (RIPK3) functions as a central regulator of necroptosis, mediating signaling transduction to activate...
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A zebrafish pparγ gene deletion reveals a protein kinase network associated with defective lipid metabolism
Peroxisome proliferator–activated receptor γ (Pparγ) is a master regulator of adipogenesis. Chronic pathologies such as obesity, cardiovascular...
