Search
Search Results
-
The mechanistic role of cardiac glycosides in DNA damage response and repair signaling
Cardiac glycosides (CGs) are a class of bioactive organic compounds well-known for their application in treating heart disease despite a narrow...
-
Cardiac Glycosides: Distribution, Properties and Specificity of Formation in Plant Cell and Organ Cultures In Vitro
AbstractSecondary metabolism (the formation of substances of specialized metabolism) is one of the distinctive specificities of the plant organism....
-
Apoptosis resistance of senescent cells is an intrinsic barrier for senolysis induced by cardiac glycosides
Targeted elimination of senescent cells, senolysis, is one of the core trends in the anti-aging therapy. Cardiac glycosides were recently proved to...
-
Cardiac glycoside ouabain efficiently targets leukemic stem cell apoptotic machinery independent of cell differentiation status
BackgroundAcute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by an accumulation of immature leukemic myeloblasts...
-
Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus
Neuroinflammation is a key component of virtually all neurodegenerative diseases, preceding neuronal loss and associating directly with cognitive...
-
Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets
Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we age. Heart function gradually declines in old age,...
-
Palliative Effect of Combined Application of Zinc and Selenium on Reproductive Injury Induced by Tripterygium Glycosides in Male Rats
The long-term use of tripterygium glycosides (TG) can lead to male reproductive damage. Research indicates that zinc and selenium exhibit a...
-
-
The cardiac glycoside ZINC253504760 induces parthanatos-type cell death and G2/M arrest via downregulation of MEK1/2 phosphorylation in leukemia cells
Overcoming multidrug resistance (MDR) represents a major obstacle in cancer chemotherapy. Cardiac glycosides (CGs) are efficient in the treatment of...
-
Cardiac glycosides are broad-spectrum senolytics
Senescence is a cellular stress response that results in the stable arrest of old, damaged or pre-neoplastic cells. Oncogene-induced senescence is...
-
Implications of deltamethrin on hematology, cardiac pathology, and gene expression in Nile tilapia (Oreochromis niloticus) and its possible amelioration with Shatavari (Asparagus racemosus)
Deltamethrin (DM) is one of the extensively used pyrethroids for controlling ectoparasites. Unfortunately, DM is highly toxic to fish as it primarily...
-
The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac Na+/K+-ATPase
BackgroundWe previously demonstrated that insulin-like growth factor-1 (IGF-1) regulates sodium/potassium adenosine triphosphatase (Na + /K + -ATPase)...
-
Phytochemicals from the Pteridaceae Family and Their Prospects as Future Drugs
Pteridaceae is the most ethnomedicinally significant fern family among pteridophytes. This family possesses numerous phytochemically sound and potent...
-
Bioactive Compounds and Biological Activities of Cyathea Species
Cyatheaceae family consists of most of the tree fern diversity with 600 species of tree ferns approximately. It includes three genera, namely,...
-
Interaction of Odoroside A, A Known Natural Cardiac Glycoside, with Na+/K+-ATPase
The nature of odoroside A, a cardiac glycoside (CG) extracted from Nerium oleander , as well as its chemical structure is quite similar to a...
-
Bioactive Compounds and Biological Activities of Cyathea Species
Cyatheaceae family consists of most of the tree fern diversity with 600 species of tree ferns approximately. It includes three genera, namely,...
-
Specificity of Growth and Synthesis of Secondary Metabolites in Cultures in vitro Digitalis lanata Ehrh.
AbstractRhizogenic, callus, and suspension cultures in vitro were obtained for Digitalis lanata and their growth, cytophysiological and biochemical...
-
Tinkering with Stevia rebaudiana Genome to Improve Its Sweetening Property and Productivity
Stevia rebaudiana has emerged as a globally important crop for its sweetening property imparted by steviol glycosides (SGs)—a class of a unique...
-
Neuronal autosis is Na+/K+-ATPase alpha 3-dependent and involved in hypoxic-ischemic neuronal death
Macroautophagy (hereafter called autophagy) is an essential physiological process of degradation of organelles and long-lived proteins. The discovery...
-
In-vitro antibacterial activities of fermented and unfermented Parkia biglobosa seeds against selected entero-pathogens
The study examined the antibacterial effects of both fermented and unfermented ethanolic extracts of Parkia biglobosa seeds against selected...
