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Cholesterol and Cytokines: Molecular Links to Atherosclerosis and Carcinogenesis
An increase of cholesterol concentration within the artery obstructs arterial blood flow once it deposits alongside the arterial wall. This results...
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Bridging tissue repair and epithelial carcinogenesis: epigenetic memory and field cancerization
The epigenome coordinates spatial-temporal specific gene expression during development and in adulthood, for the maintenance of homeostasis and upon...
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Molecular Ensembles of Microbiotic Metabolites in Carcinogenesis
AbstractThe mechanisms of carcinogenesis are extremely complex and involve multiple components that contribute to the malignant cell transformation,...
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Azoxymethane-induced carcinogenesis-like model of mouse intestine and mouse embryonic stem cell-derived intestinal organoids
BackgroundTumor modeling using organoids holds potential in studies of cancer development, enlightening both the intracellular and extracellular...
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Energy stress-induced circDDX21 promotes glycolysis and facilitates hepatocellular carcinogenesis
Cancer cells undergo metabolic reprogramming in response to hostile microenvironments, such as energy stress; however, the underlying mechanisms...
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The ubiquitin specific protease 7 stabilizes HPV16E7 to promote HPV-mediated carcinogenesis
Human papillomavirus (HPV) encoded E7 oncoprotein plays an important role in supporting the viral productive cycle and inducing cancer phenotypes....
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CUL4A silencing attenuates cervical carcinogenesis and improves Cisplatin sensitivity
CUL4A is an ubiquitin ligase deregulated in numerous pathologies including cancer and even hijacked by viruses for facilitating their survival and...
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Single-cell RNA sequencing of cervical exfoliated cells reveals potential biomarkers and cellular pathogenesis in cervical carcinogenesis
Cervical cancer (CC) is a common gynecological malignancy. Despite the current screening methods have been proved effectively and significantly...
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Circadian patterns of growth factor receptor-dependent signaling and implications for carcinogenesis
Several different signaling pathways that regulate cell proliferation and differentiation are initiated by binding of ligands to cell-surface and...
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A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis
Obesity is endemic to many developed countries. Overweight or obesity is associated with an increased risk of develo** cancer. Dysfunctional...
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Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs
Non-melanoma skin cancer (NMSC) has risen dramatically as a result of chronic exposure to sunlight ultraviolet (UV) radiation, climatic changes and...
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Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis
Hepatocarcinogenesis is initiated by repeated hepatocyte death and liver damage, and the underlying mechanisms mediating cell death and the...
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Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota
Colorectal cancer (CRC) is the third most common cancer worldwide. One of the main causes of colorectal cancer is inflammatory bowel disease (IBD),...
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The role of NF-κB in carcinogenesis of cervical cancer: opportunities and challenges
The nuclear factor-κB (NF-κB) family, consisting of several transcription factors, has been implicated in the regulation of cell proliferation and...
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New Insight into the Role of AhR in Lung Carcinogenesis
AbstractLung cancer (LC), one of the most common malignant neoplasms, is the leading cause of high cancer mortality worldwide. Smoking is a risk...
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S100A8/A9-RAGE pathway and chronic airway inflammation in smoke-induced lung carcinogenesis
BackgroundCigarette smoke-induced chronic airway inflammation increases the risk of lung cancer and plays a multifaceted role in lung cancer...
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Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats
Naked mole-rats (NMRs) have a very low spontaneous carcinogenesis rate, which has prompted studies on the responsible mechanisms to provide clues for...
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KDM6B promotes gastric carcinogenesis and metastasis via upregulation of CXCR4 expression
KDM6B (Lysine-specific demethylase 6B) is a histone lysine demethyltransferase that plays a key role in many types of cancers. However, its potential...
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Unveiling the etiological impact of GST-M1, GST-T1, and P53 genotypic variations on brain carcinogenesis
BackgroundFunctional variants of glutathione-S-transferase (GST)-M1, GST-T1, p53 might modulate brain cancer risk by altering the rate of metabolism...
