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A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways
The ten Frizzled receptors (FZDs) are essential in Wnt signaling and play important roles in embryonic development and tumorigenesis. Among these,...
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Non-canonical non-genomic morphogen signaling in anucleate platelets: a critical determinant of prothrombotic function in circulation
Circulating platelets derived from bone marrow megakaryocytes play a central role in thrombosis and hemostasis. Despite being anucleate, platelets...
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Functional role of the Frizzled linker domain in the Wnt signaling pathway
The Wnt signaling pathway plays a critical role in the developmental and physiological processes of metazoans. We previously reported that the...
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WNT Signaling in Stem Cells: A Look into the Non-Canonical Pathway
Tissue homeostasis is crucial for multicellular organisms, wherein the loss of cells is compensated by generating new cells with the capacity for...
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Canonical WNT/β-catenin signaling upregulates aerobic glycolysis in diverse cancer types
Despite many efforts, a comprehensive understanding and clarification of the intricate connections within cancer cell metabolism remain elusive. This...
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Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-β signaling pathways in cancer
BackgroundMetastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to enhance their migration, invasion, and resistance to treatments....
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Role of the Ror family receptors in Wnt5a signaling
Ror-family receptors, Ror1 and Ror2, are type I transmembrane proteins that possess an extracellular cysteine-rich domain, which is conserved...
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The interaction of canonical Wnt/β-catenin signaling with protein lysine acetylation
Canonical Wnt/β-catenin signaling is a complex cell-communication mechanism that has a central role in the progression of various cancers. The...
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Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds
Wound healing is a tightly regulated process that ensures tissue repair and normal function following injury. It is modulated by activation of...
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Wnt signaling regulates chemokine production and cell migration of circulating human monocytes
The β-catenin dependent canonical Wnt signaling pathway plays a crucial role in maintaining normal homeostasis. However, when dysregulated, Wnt...
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BML-281 promotes neuronal differentiation by modulating Wnt/Ca2+ and Wnt/PCP signaling pathway
Histone deacetylase (HDAC) inhibitors promote differentiation through post-translational modifications of histones. BML-281, an HDAC6 inhibitor, has...
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Wnt/planar cell polarity signaling controls morphogenetic movements of gastrulation and neural tube closure
Gastrulation and neurulation are successive morphogenetic processes that play key roles in sha** the basic embryonic body plan. Importantly, they...
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Wnt/β-catenin signaling pathway in liver biology and tumorigenesis
The Wnt/β-catenin pathway is an evolutionarily conserved signaling pathway that controls fundamental physiological and pathological processes by...
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Wnt, notch signaling and exercise: what are their functions?
In the last decade, the study of Wnt and Notch signaling in cell biology has led to significant progress in understanding embryogenesis, bone...
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MicroRNAs regulating Wnt signaling pathway in colorectal cancer: biological implications and clinical potentials
Colorectal cancer (CRC) is one of the most frequent cancers leading to death worldwide. Different signaling pathways such as the canonical Wnt...
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Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis
The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This differentiation process...
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Signaling Pathways in Trans-differentiation of Mesenchymal Stem Cells: Recent Advances
Mesenchymal stem cells are a group of multipotent cells that can be induced to differentiate into other cell types. The cells fate is decided by...
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Tumor endothelial cell-derived Sfrp1 supports the maintenance of cancer stem cells via Wnt signaling
Cancer stem cells (CSCs), which are critical targets for cancer therapy as they are involved in drug resistance to anticancer drugs, and metastasis,...
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Alternative Wnt-signaling axis leads to a break of oncogene-induced senescence
Oncogene-induced senescence (OIS) is an important process that suppresses tumor development, but the molecular mechanisms of OIS are still under...
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Complex and pleiotropic signaling pathways regulated by the secreted protein augurin
The secreted protein augurin, the product of the tumor suppressor gene Ecrg4 , has been identified as a peptide hormone in the human proteome in 2007....
