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1. Absence of calcium-sensing receptor basal activity due to inter-subunit disulfide bridges

   G protein-coupled receptors naturally oscillate between inactive and active states, often resulting in receptor constitutive activity with important...

   Shumin Ma, Xueliang Yin, ... Jianfeng Liu in Communications Biology

   Article Open access 25 April 2024
   

2. Alcohol Intake Provoked Cardiomyocyte Apoptosis Via Activating Calcium-Sensing Receptor and Increasing Endoplasmic Reticulum Stress and Cytosolic [Ca2+]i

   Background

   Cardiomyocyte apoptosis plays an important role in alcoholic cardiac injury. However, the association between calcium-sensing receptor...

   Wenxiu Liu, Meng Zhao, ... Yue Liu in Cell Biochemistry and Biophysics

   Article 28 August 2023
   

3. Structural insights into asymmetric activation of the calcium-sensing receptor–G_q complex

   Shenglong Ling, **anyu Meng, ... Changlin Tian in Cell Research

   Article 02 November 2023
   

4. Calcium sensing receptor stimulates breast cancer cell migration via the Gβγ-AKT-mTORC2 signaling pathway

   Calcium sensing receptor, a pleiotropic G protein coupled receptor, activates secretory pathways in cancer cells and putatively exacerbates their...

   Lennis Beatriz Orduña-Castillo, Jorge Eduardo del-Río-Robles, ... Guadalupe Reyes-Cruz in Journal of Cell Communication and Signaling

   Article 01 December 2021
   

5. Hydrogel-based molecular tension fluorescence microscopy for investigating receptor-mediated rigidity sensing

   Extracellular matrix (ECM) rigidity serves as a crucial mechanical cue impacting diverse biological processes. However, understanding the molecular...

   Wenxu Wang, Wei Chen, ... Zheng Liu in Nature Methods

   Article 05 October 2023
   

6. A role for the calcium-sensing receptor in the expression of inflammatory mediators in LPS-treated human dental pulp cells

   The aim of this study is to investigate the role of calcium-sensing receptor (CaSR) in the expression of inflammatory mediators of lipopolysaccharide...

   Shaofeng An, Yanhuo Chen, ... Yiwei Liu in Molecular and Cellular Biochemistry

   Article 14 June 2022
   

7. Calcium-sensing receptor and NF-κB pathways in TN breast cancer contribute to cancer-induced cardiomyocyte damage via activating neutrophil extracellular traps formation

   Cardiovascular disorders are commonly prevalent in cancer patients, yet the mechanistic link between them remains poorly understood. Because...

   **gya Zeng, Yangyang Cheng, ... Yihua Sun in Cellular and Molecular Life Sciences

   Article 10 January 2024
   

8. Calcium-sensing receptor in the development and treatment of pulmonary hypertension

   Calcium-sensing receptor (CaSR) is widely involved in the cell proliferation, differentiation, migration, adhesion and apoptosis, which can affect...

   Ming-Yuan Zhou, Lin Cheng, ... Yun Wang in Molecular Biology Reports

   Article 04 January 2021
   

9. Capsaicin Receptor TRPV1: Biophysics, Physiology, and Pharmacology

   The animal receptor for capsaicin, an important metabolite found in chili peppers that bestows the signature spiciness, is TRPV1 (Transient Receptor...

   Shisheng Li, Jie Zheng in Capsaicinoids

   Chapter 2024
   

10. Sodium-Induced Calcium Signaling in Plants Under Salinity Stress

    Global climate change is posing serious threat to agricultural productivity worldwide. Therefore, ensuring global food security in the light of...

    Amantika Singh, Krishna Kumar Choudhary in Metals and Metalloids in Plant Signaling

    Chapter 2024
    

11. miR-135 protects against atrial fibrillation by suppressing intracellular calcium-mediated NLRP3 inflammasome activation

    Atrial fibrillation (AF), one of the most common types of arrhythmias, is associated with high morbidity and mortality, seriously endangering human...

    Yahan Yu, Zheyu Fan, ... Baofeng Yang in Journal of Cell Communication and Signaling

    Article 24 January 2023
    

12. Small intestinal CaSR-dependent and CaSR-independent protein sensing regulates feeding and glucose tolerance in rats

    Proteins activate small intestinal calcium sensing receptor (CaSR) and/or peptide transporter 1 (PepT1) to increase hormone secretion ^{1 – 8} , but the...

    Rosa J. W. Li, Daniel R. Barros, ... Tony K. T. Lam in Nature Metabolism

    Article 02 January 2024
    

13. Liquid-liquid phase separation as a major mechanism of plant abiotic stress sensing and responses

    Identification of environmental stress sensors is one of the most important research topics in plant abiotic stress research. Traditional strategies...

    **n Liu, Jian-Kang Zhu, Chunzhao Zhao in Stress Biology

    Article Open access 11 December 2023
    

14. Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca²⁺ ions and L-tryptophan

    The human calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor (GPCR) responsible for maintaining Ca ²⁺ homeostasis in the blood....

    Shenglong Ling, Pan Shi, ... Changlin Tian in Cell Research

    Article Open access 18 February 2021
    

15. The Skeletal Muscle Calcium Channel

    CaV1.1 is the voltage-gated calcium channel isoform uniquely expressed in skeletal muscle. Its primary function is that of the voltage sensor for...

    Bernhard E. Flucher, Kurt G. Beam in Voltage-Gated Calcium Channels

    Chapter 2022
    

16. Mechanisms of endothelial flow sensing

    Fluid shear stress plays a key role in sculpting blood vessels during development, in adult vascular homeostasis and in vascular pathologies. During...

    Claire Aitken, Vedanta Mehta, ... Ellie Tzima in Nature Cardiovascular Research

    Article 12 June 2023
    

17. Efficient detection of eukaryotic calcium-sensing receptor (CaSR) by polyclonal antibody against prokaryotic expressed truncated CaSR

    Calcium-sensing receptor (CaSR), which is better known for its action as regulating calcium homeostasis, can bind various ligands. To facilitate...

    Aghdas Ramezani, Mohammad Javad Rasaee, ... Ali Hatef Salmanian in Molecular Biology Reports

    Article 01 October 2020
    

18. TMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling

    Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find...

    Chen Zhang, Fang Tong, ... Qingjian Han in Cell Discovery

    Article Open access 18 June 2024
    

19. Postprandial sodium sensing by enteric neurons in Drosophila

    Sodium is essential for all living organisms ¹ . Animals including insects and mammals detect sodium primarily through peripheral taste cells ^{2 – 7} . It is...

    Byoungsoo Kim, Gayoung Hwang, ... Greg S. B. Suh in Nature Metabolism

    Article 03 April 2024
    

20. Functional Analysis of Calcium-Sensing Receptor Variants Identified in Families Provisionally Diagnosed with Familial Hypocalciuric Hypercalcaemia

    Identification of variants in the calcium-sensing receptor ( CASR ) gene is an important means of distinguishing between familial hypocalciuric...

    Aaron L. Magno, Kassandra M. Leatherbarrow, ... Bryan K. Ward in Calcified Tissue International

    Article 08 July 2020