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IGF2BP2-meidated m6A modification of CSF2 reprograms MSC to promote gastric cancer progression
The interaction between tumor cells and stromal cells within the tumor microenvironment plays a critical role in cancer progression. Mesenchymal stem...
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miR-211-3p enhances induction chemotherapy insensitivity by upregulating CSF2/CCL20/TNF signaling in hypopharyngeal squamous cell carcinoma
PurposeTo investigate the potential mechanisms of miR-211-3p on induction chemotherapy (IC) sensitivity in hypopharyngeal squamous cell carcinoma...
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Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis
Tumor microenvironment-targeted therapies are emerging as promising treatment options for different cancer types. Tumor-associated macrophages and...
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Disrupting Smad3 potentiates immunostimulatory function of NK cells against lung carcinoma by promoting GM-CSF production
Through Smad3-dependent signalings, transforming growth factor-β (TGF-β) suppresses the development, maturation, cytokine productions and cytolytic...
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S100A9 plays a key role in Clostridium perfringens beta2 toxin-induced inflammatory damage in porcine IPEC-J2 intestinal epithelial cells
BackgroundAs an important regulator of autoimmune responses and inflammation, S100A9 may serve as a therapeutic target in inflammatory diseases....
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Determinants of survival of the bovine blastocyst to cryopreservation stress: treatment with colony stimulating factor 2 during the morula-to-blastocyst transition and embryo sex
BackgroundColony-stimulating factor 2 (CSF2) is an important maternal regulator of embryonic development. Earlier research indicates that CSF2 can...
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Identification of candidate genomic regions for egg yolk moisture content based on a genome-wide association study
BackgroundEggs represent important sources of protein and are widely loved by consumers. Egg yolk taste is an important index for egg selection, and...
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Sam68 contributes to intestinal inflammation in experimental and human colitis
Sam68 is an RNA-binding protein with an adaptor role in signal transduction. Our previous work identified critical proinflammatory and apoptotic...
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Adaptation of Human iPSC-Derived Macrophages Toward an Alveolar Macrophage-Like Phenotype Post-Intra-Pulmonary Transfer into Murine Models
Alveolar macrophages (AMs) represent crucial immune cells in the bronchioalveolar space of the lungLungs. Given the important role in the host...
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Transcriptomic analysis of glucosidase II beta subunit (GluIIß) knockout A549 cells reveals its roles in regulation of cell adhesion molecules (CAMs) and anti-tumor immunity
Glucosidase II beta subunit (GluIIß), encoded from PRKCSH , is a subunit of the glucosidase II enzyme responsible for quality control of N-linked...
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Characterization of rumen microbiome and immune genes expression of crossbred beef steers with divergent residual feed intake phenotypes
We investigated whole blood and hepatic mRNA expressions of immune genes and rumen microbiome of crossbred beef steers with divergent residual feed...
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Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis
The novel betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a worldwide pandemic (COVID-19) after emerging in...
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Transcriptomic analysis of the seminal vesicle response to the reproductive toxicant acrylamide
BackgroundThe seminal vesicles synthesise bioactive factors that support gamete function, modulate the female reproductive tract to promote...
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Differential gene expression of Wharton’s jelly-derived mesenchymal cells mediated by graphene oxide in basal and osteo-induced media
BackgroundGraphene oxide (GO) is widespread in scaffold engineering owing to its extraordinary properties such as multiple oxygen functional groups,...
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Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism
Lung cancer is a heterogeneous and complex disease with the highest incidence and mortality rate. The present study aims at defining the lung cancer...
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Detailed Insight into Various Classes of the CRISPR/Cas System to Develop Future Crops
Breeders and scientists are working to enhance the quality and yield of the main food crops in order to meet the growing worldwide demand for food....
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Das Immunsystem
In diesem Kapitel wird die Bedeutung von Epigenetik für die Funktion des Immunsystem vorgestellt. Das beginnt mit der Hämatopoese, d. h. der...
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Evaluations of carcinogens from comparison of cancer slope factors: meta-analysis and systemic literature reviews
BackgroundThis study seeks to estimate whether a chemical has carcinogenic potential; and if it has carcinogenic activity, its carcinogenic efficacy...
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LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation
Long non-coding RNAs (lncRNAs) interaction with RNA-Binding proteins (RBPs) plays an important role in immunological processes. The generation of...
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Advances in ovarian tumor stem cells and therapy
Ovarian cancer is considered the most lethal among all gynecological malignancies due to its early metastatic dissemination, extensive spread, and...
