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High prevalence of CD44 and its ligand low molecular weight hyaluronan in plasma of HNSCC patients: clinical significance
BackgroundThis study aims to evaluate the role of cancer stem cell marker, CD44, and its ligand HA as potential molecular biomarker for early...
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CD44: Does CD44v6 Adversely Impact the Prognosis of Cancer Patients?
Colorectal cancer (CRC) is the third leading cause of cancer-related death in the USA. This high level of CRC death is primarily due to...
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Characterization of CD44 intracellular domain interaction with RUNX2 in PC3 human prostate cancer cells
BackgroundExpression of CD44 receptor is associated with the onset of several tumors. The intracellular domain of CD44 (CD44-ICD) has been implicated...
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Induction of immunogenic cell death in radiation-resistant breast cancer stem cells by repurposing anti-alcoholism drug disulfiram
BackgroundThe current successful clinical use of agents promoting robust anti-tumor immunity in cancer patients warrants noting that radiation...
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Loss of Epidermal Homeostasis Underlies the Development of Squamous Cell Carcinoma
Squamous cell carcinoma (SCC) is one of the most common skin cancers. To develop targeted therapies for SCC, a comprehensive understanding of the...
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The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells
N-terminal HSP90 inhibitors in development have had issues arising from heat shock response (HSR) induction and off-target effects. We sought to...
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CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response
The cell adhesion molecule CD44 has been implicated in diverse biological functions including the pathological responses to infections and...
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Modified mesenchymal stromal cells by in vitro transcribed mRNA: a therapeutic strategy for hepatocellular carcinoma
BackgroundMesenchymal stromal cells (MSCs) tropism for tumours allows their use as carriers of antitumoural factors and in vitro transcribed mRNA...
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Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop
Enhancement of Wnt signaling is fundamental for stem cell function during intestinal regeneration. Molecular modules control Wnt activity by...
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GSK3β is a critical, druggable component of the network regulating the active NOTCH1 protein and cell viability in CLL
NOTCH1 alterations have been associated with chronic lymphocytic leukemia (CLL), but the molecular mechanisms underlying NOTCH1 activation in CLL...
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Cancer treatment therapies: traditional to modern approaches to combat cancers
As far as health issues are concerned, cancer causes one out of every six deaths around the globe. As potent therapeutics are still awaited for the...
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Ferroptosis and EMT: key targets for combating cancer progression and therapy resistance
Iron-dependent lipid peroxidation causes ferroptosis, a form of regulated cell death. Crucial steps in the formation of ferroptosis include the...
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Nanozyme-Based Enhanced Cancer Immunotherapy
Catalytic nanoparticles with natural enzyme-mimicking properties, known as nanozymes, have emerged as excellent candidate materials for cancer...
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Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity
Cancer immunotherapy has transformed traditional treatments, with immune checkpoint blockade being particularly prominent. However, immunotherapy has...
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Necroptosis stimulates interferon-mediated protective anti-tumor immunity
Necroptosis is an inflammatory form of cell suicide that critically depends on the kinase activity of Receptor Interacting Protein Kinase 3 (RIPK3)....
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An oncolytic virus–T cell chimera for cancer immunotherapy
The efficacy of oncolytic adenoviruses (OAs) for cancer therapy has been limited by insufficient delivery to tumors after systemic injection and the...
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Cuproptosis in cancer: biological implications and therapeutic opportunities
Cuproptosis, a newly identified copper (Cu)-dependent form of cell death, stands out due to its distinct mechanism that sets it apart from other...
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CD74 is a functional MIF receptor on activated CD4+ T cells
Next to its classical role in MHC II-mediated antigen presentation, CD74 was identified as a high-affinity receptor for macrophage migration...
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Intravenous injection of the oncolytic virus M1 awakens antitumor T cells and overcomes resistance to checkpoint blockade
Reversing the highly immunosuppressive tumor microenvironment (TME) is essential to achieve long-term efficacy with cancer immunotherapy. Despite the...
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TNFα modulates PANX1 activation to promote ATP release and enhance P2RX7-mediated antitumor immune responses after chemotherapy in colorectal cancer
ATP and its receptor P2RX7 exert a pivotal effect on antitumor immunity during chemotherapy-induced immunogenic cell death (ICD). Here, we...
