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Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics
Caspase-2 (Casp2) is a promising therapeutic target in several human diseases, including nonalcoholic steatohepatitis (NASH) and Alzheimer’s disease...
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Long non-coding RNA TPT1-AS1 sensitizes breast cancer cell to paclitaxel and inhibits cell proliferation by miR-3156-5p/caspase 2 axis
Long non-coding RNAs (lncRNAs) are key modulators during cancer progression. Application of using lncRNA expression to evaluate patient prognosis and...
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Caspase-2 protects against ferroptotic cell death
Caspase-2, one of the most evolutionarily conserved members of the caspase family, is an important regulator of the cellular response to oxidative...
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Maternal supplementation with n-3 fatty acids affects placental lipid metabolism, inflammation, oxidative stress, the endocannabinoid system, and the neonate cytokine concentrations in dairy cows
BackgroundThe placenta plays a crucial role in supporting and influencing fetal development. We compared the effects of prepartum supplementation...
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Programmed Cell Death and its Implications for Skeletal Muscle Wasting
Skeletal muscle atrophy is an inevitable sequel of various factors such as cachexia, aging, fasting, denervation, and microgravity. It is...
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Acute and short-term fluctuations in gravity are associated with changes in circulatory plasma protein levels
Gravitational changes between micro- and hypergravity cause several adaptations and alterations in the human body. Besides muscular atrophy and...
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Tumor suppressor p53 mediates interleukin-6 expression to enable cancer cell evasion of genotoxic stress
The tumor suppressor p53 primarily functions as a mediator of DNA damage-induced cell death, thereby contributing to the efficacy of genotoxic...
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The Dysfunction of Carcinogenesis- and Apoptosis-Associated Genes that Develops in the Hypothalamus under Chronic Social Defeat Stress in Male Mice
AbstractChronic social stress caused by daily agonistic interactions in male mice leads to a mixed anxiety/depression-like disorder that is...
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Permission to pass: on the role of p53 as a gatekeeper for aneuploidy
Aneuploidy—the karyotype state in which the number of chromosomes deviates from a multiple of the haploid chromosome set—is common in cancer, where...
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Apoptotic cell death in disease—Current understanding of the NCCD 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that...
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Multipronged regulation of autophagy and apoptosis: emerging role of TRIM proteins
TRIM proteins are characterized by their conserved N-terminal RING, B-box, and coiled-coil domains. These proteins are efficient regulators of...
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The molecular mechanisms of vulpinic acid induced programmed cell death in melanoma
BackgroundsMalignant melanoma is an aggressive skin tumor with a rapidly increasing incidence and there is not yet a successful treatment strategy....
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Cell Cycle Regulation in Mammalian Germ Cells
Meiosis is a unique form of cellular division by which a diploid cell produces genetically distinct haploid gametes. Initiation and regulation of...
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Transcriptome During Normal Cell Differentiation
This chapter provides a review of recent advances in understanding the importance of normal cell differentiation and the key regulators that...
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Pigment epithelium-derived factor mediates retinal ganglion cell neuroprotection by suppression of caspase-2
Retinal ganglion cells (RGCs) undergo rapid cell death by apoptosis after injury but can be rescued by suppression of caspase-2 (CASP2) using an...
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Unveiling caspase-2 regulation by non-coding RNAs
Non-coding RNAs (ncRNAs) are a group of RNA molecules, such as small nucleolar RNAs, circular RNAs (circRNAs), microRNAs (miRNAs) and long-noncoding...
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Transcriptome profiling of caspase-2 deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling
Caspase-2 is a highly conserved cysteine protease with roles in apoptosis and tumor suppression. Our recent findings have also demonstrated that the...
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Caspase 8 deletion causes infection/inflammation-induced bone marrow failure and MDS-like disease in mice
Myelodysplastic syndromes (MDS) are a heterogeneous group of pre-leukemic hematopoietic disorders characterized by cytopenia in peripheral blood due...
