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Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc
Acetate, a precursor of acetyl-CoA, is instrumental in energy production, lipid synthesis and protein acetylation. However, whether acetate...
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LncRNA SNHG26 promotes gastric cancer progression and metastasis by inducing c-Myc protein translation and an energy metabolism positive feedback loop
Metastasis is a bottleneck in cancer treatment. Studies have shown the pivotal roles of long noncoding RNAs (lncRNAs) in regulating cancer...
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Enhanced branched-chain amino acid metabolism improves age-related reproduction in C. elegans
Reproductive ageing is one of the earliest human ageing phenotypes, and mitochondrial dysfunction has been linked to oocyte quality decline; however,...
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Lipid Metabolism
Lipids are a heterogeneous group of water-insoluble compounds that are soluble in organic solvents. Besides being an important constituent of the...
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Concepts in Metabolism
Though the vitalist group initially used the term “organic” for compounds produced only by organisms, it was later on used for carbon compounds....
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Fermentative Metabolism
Metabolic pathways are mosaics of a limited set of metabolic modules and prototypic reactions. Mosaic pathways also include important metabolic...
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Nitrogen Metabolism
Nitrogen is one of the most important macronutrients required by plants. All proteins consist of nitrogen-containing amino acids. Heme components of...
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Metabolism of Storage Carbohydrates
Besides playing other roles, carbohydrates are also the major source of energy for all living beings. Almost 30% of the carbohydrates in plants are...
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mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A
BackgroundExploiting cancer metabolism during nutrient availability holds immense potential for the clinical and therapeutic benefits of...
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Salinity affects C/N ratio through differential responses of carbon and nitrogen metabolism in mangrove Avicennia marina leaves revealed by combined analysis of transcriptome and metabolome
Background and aimsSalt is a critical environmental factor that profoundly impacts plant growth and development. However, the investigation into how...
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C. elegans Methods and Applications
This detailed new edition provides a guide for implementing a selection of novel techniques utilizing the pioneering organism, Caenorhabditis elegans,...
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C4-like Sesuvium sesuvioides (Aizoaceae) exhibits CAM in cotyledons and putative C4-like + CAM metabolism in adult leaves as revealed by transcriptome analysis
BackgroundThe co-occurrence of C 4 and CAM photosynthesis in a single species seems to be unusual and rare. This is likely due to the difficulty in...
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Skeletal Muscle Energy Metabolism & Contraction
Skeletal muscle contraction and energy metabolism are closely intertwined processes essential for maintaining physiological functions and supporting...
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Imbalanced metabolism induced NH4+ accumulation and its effect on the central metabolism of Methylomonas sp. ZR1
Nitrogen and carbon are the two most essential nutrient elements, and their metabolism is tightly coupled in single carbon metabolic microorganisms....
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The desert plant Calotropis procera maintains C3 photosynthetic metabolism under salt stress
The C 3 plant Calotropis procera is native to arid desert zones with a pan-tropical distribution. For this species, the leaf mesophyll conductance ( g m )...
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β-Escin reduces cancer progression in aggressive MDA-MB-231 cells by inhibiting glutamine metabolism through downregulation of c-myc oncogene
BackgroundThe c-myc oncogene, which causes glutamine dependence in triple negative breast cancers (TNBC), is also the target of one of the signaling...
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The Role of C1473G Polymorphism in Mouse Triptophan Hydroxylase 2 Gene in the Acute Effects of Ethanol on the c-fos Gene Expression and Metabolism of Biogenic Amines in the Brain
AbstractTryptophan hydroxylase 2 is a key enzyme in the synthesis of the neurotransmitter serotonin, which plays an important role in the regulation...
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Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities
Accumulating evidence over the past decades has revealed an intricate relationship between dysregulation of cellular metabolism and the progression...
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Extracellular domains of CARs reprogramme T cell metabolism without antigen stimulation
Metabolism is an indispensable part of T cell proliferation, activation and exhaustion, yet the metabolism of chimeric antigen receptor (CAR)-T cells...
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Metabolism-regulated ferroptosis in cancer progression and therapy
Cancer metabolism mainly includes carbohydrate, amino acid and lipid metabolism, each of which can be reprogrammed. These processes interact with...
