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Epigenetic resha** through damage: promoting cell fate transition by BrdU and IdU incorporation
BackgroundThymidine analogs have long been recognized for their ability to randomly incorporate into DNA. However, the precise mechanisms through...
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BrdU Incorporation Assay to Analyze the Entry into S Phase
5-Bromo-2′-deoxyuridine (bromodeoxyuridine (BrdU)), a modified nucleotide and analog of thymidine, is commonly used for detecting proliferating...
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BrdU Incorporation and Labeling of Nascent DNA to Investigate Archaeal Replication Using Super-Resolution Imaging
The labeling and specific detection of nascent DNA by the incorporation of thymidine analogs provide crucial information about DNA replication...
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Ki67 Protein: Important Proliferative Marker for Cultured Mesenchymal Stem Cells Evaluation
Bone marrow-derived mesenchymal stem cells (BM-MSCs) have attracted increasing attention in recent years as a possible reserve of stem cells that may...
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Analysis for Sister Chromatid Exchange
Sister chromatid exchange (SCE) is the exchange event of genetic material between two identical sister chromatid. Elevation of SCE frequency is...
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Combining BrdU-Labeling to Detection of Neuronal Markers to Monitor Adult Neurogenesis in Hydra
The nervous system is produced and maintained in adult Hydra through the continuous production of nerve cells and mechanosensory cells (nematocytes...
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Comparing the mesenchymal stem cells proliferation rate with different labeling assessments
Adipose tissue-derived mesenchymal stem cells (AD-MSCs) are an appropriate source for regenerative medicine and transplantation therapy due to their...
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Preparing Planarian Cells for High-Content Fluorescence Microscopy Using RNA in Situ Hybridization and Immunocytochemistry
High-content fluorescence microscopy combines the efficiency of high-throughput techniques with the ability to extract quantitative information from...
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Hypoxia preconditioning increases Notch1 activity by regulating DNA methylation in vitro and in vivo
BackgroundOur previous research has demonstrated that hypoxic preconditioning (HPC) can improve spatial learning and memory abilities in adult mice....
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Monitoring Cellular Proliferation , Migration, and Apoptosis Associated with Atherosclerosis Plaques In Vitro
Bromodeoxyuridine/5-bromo-2′-deoxyuridine (BrdU) is a nucleoside analog of thymidine and its incorporation into DNA during replication within S-phase...
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Monitoring Cellular Proliferation and Apoptosis in Atherosclerosis Plaques and Intimal Thickenings
Immunohistochemistry for specific proteins characteristic of proliferative or apoptotic cells allows for monitoring of these cell behaviors in...
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Application of EdU-Based DNA Synthesis Assay to Measure Hepatocyte Proliferation In Situ During Liver Regeneration
Monitoring hepatocyte proliferation in situ following partial hepatectomy is widely used to characterize cytokines, growth factors and signaling...
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MiR129-5p-loaded exosomes suppress seizure-associated neurodegeneration in status epilepticus model mice by inhibiting HMGB1/TLR4-mediated neuroinflammation
BackgroundNeuroinflammation contributes to both epileptogenesis and the associated neurodegeneration, so regulation of inflammatory signaling is a...
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Neurotrophic factor-secreting cells restored endogenous hippocampal neurogenesis through the Wnt/β-catenin signaling pathway in AD model mice
BackgroundImpairment in neurogenesis correlates with memory and cognitive dysfunction in AD patients. In the recent decade, therapies with stem cell...
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FORK-seq: Single-Molecule Profiling of DNA Replication
Most genome replication map** methods profile cell populations, masking cell-to-cell heterogeneity. Here, we describe FORK-seq, a nanopore...
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Detection of markers for proliferation, stem cell, and EMT in the gills of Pacific abalone Haliotis discus hannai
The hemocytes of molluscs take various roles including immunity and wound healing. Oyster gill was found to undergo hematopoiesis and produce adult...
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Does Boric Acid Inhibit Cell Proliferation on MCF-7 and MDA-MB-231 Cells in Monolayer and Spheroid Cultures by Using Apoptosis Pathways?
Most breast cancers originate in the lobules or ducts of the breast. Breast cancer as the second main cause of death among women in the world is the...
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Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model
BackgroundImpaired pattern separation occurs in the early stage of Alzheimer’s disease (AD), and hippocampal dentate gyrus (DG) neurogenesis...
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Long Non-Coding RNA PCAT19 Suppresses Cell Proliferation and Angiogenesis in Coronary Artery Disease through Interaction with GCNT2
LncRNAs involvement in heart disease, however, the effect of lncRNA prostate cancer‐associated transcript 19 (PCAT19) in coronary artery disease...
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Morin hydrate ameliorates heat-induced testicular impairment in a mouse model
BackgroundHeat stress is known to adversely affect testicular activity and manifest the pathogenesis of spermatogenesis. Morin hydrate is a...
