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Delivering Traumatic Brain Injury to Larval Zebrafish
We describe a straightforward, scalable method for administering traumatic brain injury (TBI) to zebrafish larvae. The pathological outcomes appear...
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Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review
Clinical outcome after traumatic brain injury (TBI) is closely associated conditions of other organs, especially lungs as well as degree of brain...
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Neuron-secreted NLGN3 ameliorates ischemic brain injury via activating Gαi1/3-Akt signaling
We here tested the potential activity and the underlying mechanisms of neuroligin-3 (NLGN3) against ischemia-reperfusion-induced neuronal cell...
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Zebrafish As a Promising Experimental Model of Traumatic Brain Injury
AbstractTraumatic brain injury (TBI) involves multiple types of physical brain lesions. TBI is a highly heterogeneous clinical condition whose...
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Sphingolipid changes in mouse brain and plasma after mild traumatic brain injury at the acute phases
BackgroundTraumatic brain injury (TBI) causes neuroinflammation and can lead to long-term neurological dysfunction, even in cases of mild TBI (mTBI)....
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Schizandrin A attenuates early brain injury following subarachnoid hemorrhage through suppressing neuroinflammation
BackgroundEarly brain injury (EBI) is the vital factor in determining the outcome of subarachnoid hemorrhage (SAH). Schizandrin A (Sch A), the...
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Roles and therapeutic potential of different extracellular vesicle subtypes on traumatic brain injury
Traumatic brain injury (TBI) is a leading cause of injury-related disability and death around the world, but the clinical stratification, diagnosis,...
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Dopamine enhances recovery after traumatic brain injury through ubiquitylation and autophagic degradation of RIPK1
BackgroundAlthough the neurotransmitter dopamine (DA) plays a crucial pathophysiologic role after traumatic brain injury (TBI), its function and...
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FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control
Mitochondrial dysfunction and oxidative stress are important mechanisms for secondary injury after traumatic brain injury (TBI), which result in...
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Set7/9 aggravates ischemic brain injury via enhancing glutamine metabolism in a blocking Sirt5 manner
The aberrant expression of methyltransferase Set7/9 plays a role in various diseases. However, the contribution of Set7/9 in ischemic stroke remains...
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DCC/netrin-1 regulates cell death in oligodendrocytes after brain injury
Hallmark pathological features of brain trauma are axonal degeneration and demyelination because myelin-producing oligodendrocytes (OLs) are...
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Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model
Traumatic Brain injury-induced disturbances in mitochondrial fission-and-fusion dynamics have been linked to the onset and propagation of...
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Endoplasmic reticulum stress and the unfolded protein response: emerging regulators in progression of traumatic brain injury
Traumatic brain injury (TBI) is a common trauma with high mortality and disability rates worldwide. However, the current management of this disease...
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Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury
Perinatal brain injury is a leading cause of death and disability in children. Hypoxic-ischemic encephalopathy in full term infants, and white matter...
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3D printing of injury-preconditioned secretome/collagen/heparan sulfate scaffolds for neurological recovery after traumatic brain injury in rats
BackgroundThe effects of traumatic brain injury (TBI) can include physical disability and even death. The development of effective therapies to...
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Liensinine ameliorates ischemia–reperfusion-induced brain injury by inhibiting autophagy via PI3K/AKT signaling
The current study aimed to explore the role of autophagy in cerebral ischemia–reperfusion injuries (CIRI) and elucidate the efficacy of liensinine...
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Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury
Adults aged 60 and over are most vulnerable to mild traumatic brain injury (mTBI). Nevertheless, the extent to which chronological age (CA) at injury...
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Neural stem cell-derived exosomes and regeneration: cell-free therapeutic strategies for traumatic brain injury
Regenerative repair of the brain after traumatic brain injury (TBI) remains an extensive clinical challenge, inspiring intensified interest in...
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Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia
Traumatic brain injury (TBI) is one of the foremost causes of disability and mortality globally. While the scientific and medical emphasis is to save...
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Map** dynamic molecular changes in hippocampal subregions after traumatic brain injury through spatial proteomics
BackgroundTraumatic brain injury (TBI) often results in diverse molecular responses, challenging traditional proteomic studies that measure average...
