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Alzheimer’s disease rewires gene coexpression networks coupling different brain regions
Connectome studies have shown how Alzheimer’s disease (AD) disrupts functional and structural connectivity among brain regions. But the molecular...
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Endothelial DR6 in blood-brain barrier malfunction in Alzheimer’s disease
The impairment of the blood-brain barrier (BBB) has been increasingly recognised as a critical element in the early pathogenesis of Alzheimer’s...
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Is blood-brain barrier a probable mediator of non-invasive brain stimulation effects on Alzheimer’s disease?
Alzheimer’s disease (AD) is a complex neurodegenerative disease with no existing treatment leading to full recovery. The blood-brain barrier (BBB)...
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Sex difference in brain functional connectivity of hippocampus in Alzheimer’s disease
Alzheimer’s disease (AD), affecting nearly 6.5 million people, is the fifth leading cause of death in individuals 65 years or older in the USA. Prior...
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Mitigating gut microbial degradation of levodopa and enhancing brain dopamine: Implications in Parkinson’s disease
Parkinson’s disease is managed using levodopa; however, as Parkinson’s disease progresses, patients require increased doses of levodopa, which can...
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Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer’s disease
Neuronal dysfunction and cognitive deterioration in Alzheimer’s disease (AD) are likely caused by multiple pathophysiological factors. However,...
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A rationale for considering heart/brain axis control in neuropsychiatric disease
Neuropsychiatric diseases (NPD) represent a significant global disease burden necessitating innovative approaches to pathogenic understanding,...
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Knockout of the longevity gene Klotho perturbs aging and Alzheimer’s disease-linked brain microRNAs and tRNA fragments
Overexpression of the longevity gene Klotho prolongs lifespan, while its knockout shortens lifespan and impairs cognition via perturbation of...
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Graph Theory-Based Approach in Brain Connectivity Modeling and Alzheimer’s Disease Detection
There is strong evidence that the pathological findings of Alzheimer’s disease (AD), consisting of accumulated amyloid plaques and neurofibrillary...
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Intrinsic aerobic capacity modulates Alzheimer’s disease pathological hallmarks, brain mitochondrial function and proteome during aging
Low aerobic capacity is strongly associated with all-cause mortality and risk for Alzheimer’s disease (AD). Individuals with early dementia and AD...
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Brain control of dual-task walking can be improved in aging and neurological disease
The peak prevalence of multiple sclerosis has shifted into older age groups, but co-occurring and possibly synergistic motoric and cognitive declines...
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Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies
The brain’s network of perivascular channels for clearance of excess fluids and waste plays a critical role in the pathogenesis of several...
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Zika virus infection accelerates Alzheimer’s disease phenotypes in brain organoids
Alzheimer’s disease (AD) is one of the progressive neurodegenerative diseases characterized by β-amyloid (Aβ) production and Phosphorylated-Tau...
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Neurogenesis in Neurogenic Niches of the Brain in Experimental Alzheimer’s Disease at the Presymptomatic Stage of Neurodegeneration Development
AbstractDeciphering the mechanisms of neurodegeneration development at the presymptomatic stage is an urgent task, the solution of which will help...
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Intrastriatal injection of Parkinson’s disease intestine and vagus lysates initiates α-synucleinopathy in rat brain
Parkinson’s disease (PD) is characterized by the selective loss of dopaminergic neurons in the midbrain and the pathological accumulation of...
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Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review
Clinical outcome after traumatic brain injury (TBI) is closely associated conditions of other organs, especially lungs as well as degree of brain...
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Imaging of brain barrier inflammation and brain fluid drainage in human neurological diseases
The intricate relationship between the central nervous system (CNS) and the immune system plays a crucial role in the pathogenesis of various...
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Insights in the Cross-Talk Between Microbiota-Gut-Brain Axis: A Focus on Alzheimer’s Disease
The gut microbiota (GM) signifies a broad and dynamic group of microorganisms that impact the host’s health as well as metabolic processes and...
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Muscular Swedish mutant APP-to-Brain axis in the development of Alzheimer’s disease
Alzheimer’s disease (AD) is the most common form of dementia. Notably, patients with AD often suffer from severe sarcopenia. However, their direct...
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Exosomes Based Drug Delivery Strategies for Brain Disorders
This book provides a comprehensive overview of the role of exosomes in brain diseases, including stroke, multiple sclerosis, Parkinson's disease,...
