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Bone Grafting in the Regenerative Reconstruction of Critical-Size Long Bone Segmental Defects
Regenerative reconstruction of critical-size long bone segmental defects (LBSD) arising from high-energy traumas or tumor resections presents a...
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Mechanics Predicts Effective Critical-Size Bone Regeneration Using 3D-Printed Bioceramic Scaffolds
BACKGROUND:3D-printed bioceramic scaffolds have gained popularity due to their controlled microarchitecture and their proven biocompatibility....
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Effects of demineralization mode and particle size of allogeneic bone powder on its physical and chemical properties
At present, the commonly used allogeneic bone powder in the clinic can be divided into nondemineralized bone matrix and demineralized bone matrix...
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Relative influence on cell behaviors of osteoblasts seeded onto demineralized bone matrix with diverse particle size
Demineralized bone matrix (DBM) is a natural and collagen-based allogeneic bone graft material with good bioactivity and biocompatibility. However,...
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Acceleration of bone repairation by BMSCs overexpressing NGF combined with NSA and allograft bone scaffolds
BackgroundRepairation of bone defects remains a major clinical problem. Constructing bone tissue engineering containing growth factors, stem cells,...
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3D Bioprinting in Conjunction with Bone Marrow Mesenchymal Stem Cells for the Treatment of Bone Defects
Clinical management of bone defects remains a challenge. Currently, the principal therapeutic option is autologous or synthetic bone grafting....
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3′-Sialyllactose alleviates bone loss by regulating bone homeostasis
Osteoporosis is a common skeletal disease that results in an increased risk of fractures. However, there is no definitive cure, warranting the...
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Non-bone-derived exosomes: a new perspective on regulators of bone homeostasis
Accumulating evidence indicates that exosomes help to regulate bone homeostasis. The roles of bone-derived exosomes have been well-described;...
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Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity
Obesity adversely affects bone and fat metabolism in mice and humans. Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been shown to improve...
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Paget Disease of Bone Harboring Bone Metastatic Neuroendocrine Cancer: A Case Report
In this case report, we describe an uncommon case of neuroendocrine cancer of unknown origin began with cauda equina syndrome in a patient affected...
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Osteoinductive micro-nano guided bone regeneration membrane for in situ bone defect repair
BackgroundBiomaterials used in bone tissue engineering must fulfill the requirements of osteoconduction, osteoinduction, and osseointegration....
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Current Approaches in Vertical Bone Augmentation and Large Bone Deficiencies in the Orofacial Region
Bone regeneration in the orofacial region is a significant health and economic burden. While surgical techniques for the treatment of bone...
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Laser Micromachining of Bone as a Tool for Studying Bone Marrow Biology
The bone marrowBone marrow (BM) has traditionally been a difficult tissue to access because it is embedded deep within the bone matrix. It is home to...
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Bone Regeneration with 3D-Printed Hybrid Bone Scaffolds in a Canine Radial Bone Defect Model
Background:The repair of large bone defects remains a significant challenge in clinical practice and requires bone grafts or substitute materials. In...
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Bone Morphogenic Protein-2-Conjugated Three-Dimensional-Printed Poly (L-Lactic Acid) (PLLA) Scaffold is likely Promising as an Effective Bone Substitute
Bone morphogenic protein-2 (BMP-2)-conjugated three-dimensional (3-D)-printed poly (L-lactic acid)(PLLA) scaffold is likely promising as an effective...
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3D Bioprinting in Conjunction with Bone Marrow Mesenchymal Stem Cells for the Treatment of Bone Defects
Clinical management of bone defects remains a challenge. Currently, the principal therapeutic option is autologous or synthetic bone grafting....
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Rib remodelling changes with body size in fossil hippopotamuses from Cyprus and Greece
Large species that are isolated for thousands of years on islands often evolve extreme degrees of dwarfism. Very little is known about physiological...
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The role of integrin family in bone metabolism and tumor bone metastasis
Integrins have been the research focus of cell-extracellular matrix adhesion (ECM) and cytokine receptor signal transduction. They are involved in...
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Bone Density and Trabecular Bone Score Decline Rapidly in the First Year After Bone Marrow Transplantation with a Marked Increase in 10-Year Fracture Risk
As outcomes from allogeneic bone marrow transplantation (BMT) have improved, prevention of long-term complications, such as fragility fractures, has...
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Pilot Study: Short Term Impact of Radiation Therapy on Bone Mineral Density and Bone Metabolism
Despite the risk of complications, high dose radiation therapy is increasingly utilized in the management of selected bone malignancies. In this...
