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Roles of extracellular vesicles on macrophages in inflammatory bone diseases
Inflammatory bone disease is a general term for a series of diseases caused by chronic inflammation, which leads to the destruction of bone...
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HSC70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction
Inflammation leads to systemic osteoporosis or local bone destruction, however, the underlying molecular mechanisms are still poorly understood. In...
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Mesenchymal stem cell-derived extracellular vesicles: a regulator and carrier for targeting bone-related diseases
The escalating threat of bone-related diseases poses a significant challenge to human health. Mesenchymal stem cell (MSC)-derived extracellular...
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The role of WWP1 and WWP2 in bone/cartilage development and diseases
Bone and cartilage diseases are often associated with trauma and senescence, manifested as pain and limited mobility. The repair of bone and...
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Mesenchymal stem cells and their extracellular vesicles in bone and joint diseases: targeting the NLRP3 inflammasome
The nucleotide-binding oligomerization domain-like-receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a cytosolic multi-subunit...
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Inflammatory Biomarkers in Periodontitis and Their Effect on the Stem/Progenitor Cells: Molecular Basis of Bone Resorption and Bone Regeneration
Periodontitis is considered one of the most chronic inflammatory diseases damaging the soft and hard tissues supporting the teeth. In periodontitis,...
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Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases
As global aging accelerates, the prevention and treatment of age-related bone diseases are becoming a critical issue. In the process of senescence,...
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Inflammatory Biomarkers in Periodontitis and Their Effect on the Stem/Progenitor Cells: Molecular Basis of Bone Resorption and Bone Regeneration
Periodontitis is considered one of the most chronic inflammatory diseases damaging the soft and hard tissues supporting the teeth. In periodontitis,...
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The role of integrin family in bone metabolism and tumor bone metastasis
Integrins have been the research focus of cell-extracellular matrix adhesion (ECM) and cytokine receptor signal transduction. They are involved in...
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Bone Neoplasia and Skeletal Dysplasia
Cancer is one of the most dangerous diseases and is widely recognized as a civilization disease related to the development of our civilization. The...
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Beyond immunosuppressive effects: dual roles of myeloid-derived suppressor cells in bone-related diseases
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells (IMCs) with immunosuppressive functions, whereas...
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O-GlcNAcylation: roles and potential therapeutic target for bone pathophysiology
O-linked N-acetylglucosamine (O-GlcNAc) protein modification (O-GlcNAcylation) is a critical post-translational modification (PTM) of cytoplasmic and...
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Mechanistic insights into bone remodelling dysregulation by human viral pathogens
Bone-related diseases (osteopathologies) associated with human virus infections have increased around the globe. Recent findings have highlighted the...
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Unveiling the therapeutic promise: exploring Lysophosphatidic Acid (LPA) signaling in malignant bone tumors for novel cancer treatments
Malignant bone tumors, including primary bone cancer and metastatic bone tumors, are a significant clinical challenge due to their high frequency of...
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Cholesteatoma Severely Impacts the Integrity and Bone Material Quality of the Incus
Cholesteatoma can lead to progressive destruction of the auditory ossicles along with conductive hearing loss but precise data on the...
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3′-Sialyllactose alleviates bone loss by regulating bone homeostasis
Osteoporosis is a common skeletal disease that results in an increased risk of fractures. However, there is no definitive cure, warranting the...
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Extracts and Composites of Equisetum for Bone Regeneration
The present chapter reviews the different preparation and characterization of Equisetum extracts and composites, including their biological...
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Observation of a Bone Invasion Model of Aspergillus fumigatus In Vitro and Analysis of the Antifungal Susceptibility
BackgroundRecently, the prevalence of invasive fungal infections has been on the rise, and one of the prevalent symptoms frequently observed is bone...
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Bone Marrow Nucleated Cells and Bone Marrow-Derived CD271+ Mesenchymal Stem Cell in Treatment of Encephalopathy and Drug-Resistant Epilepsy
The broad spectrum of brain injuries in preterm newborns and the plasticity of the central nervous system prompts us to seek solutions for...
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Therapeutic Applications of Oxysterols and Derivatives in Age-Related Diseases, Infectious and Inflammatory Diseases, and Cancers
Oxysterols, resulting from the oxidation of cholesterol, are formed either by autoxidation, enzymatically, or by both processes. These molecules,...