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Single-cell profiling of the microenvironment in human bone metastatic renal cell carcinoma
Bone metastasis is of common occurrence in renal cell carcinoma with poor prognosis, but no optimal treatment approach has been established for bone...
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Handbook of Stem Cell Applications
This handbook reviews the clinical applications of stem cell-based therapy. The book covers the clinical applications of stem cells in cardiovascular...
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MiRNAs regulate cell communication in osteogenesis-angiogenesis coupling during bone regeneration
Bone regeneration is a complex process that requires not only the participation of multiple cell types, but also signal communication between cells....
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Cell cycle regulators and bone: development and regeneration
Cell cycle regulators act as inhibitors or activators to prevent cancerogenesis. It has also been established that they can play an active role in...
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Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis
The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This differentiation process...
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Mesenchymal stem cell-derived extracellular vesicles: a regulator and carrier for targeting bone-related diseases
The escalating threat of bone-related diseases poses a significant challenge to human health. Mesenchymal stem cell (MSC)-derived extracellular...
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Optimized Method of 3D Scaffold Seeding, Cell Cultivation, and Monitoring Cell Status for Bone Tissue Engineering
The cultivation of cells in 3D systems is commonly regarded to be more physiological than in 2D as it comes much closer to the natural situation in...
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Establishment and characterization of two novel patient-derived cell lines from giant cell tumor of bone: NCC-GCTB8-C1 and NCC-GCTB9-C1
Giant cell tumor of bone (GCTB) is a rare osteolytic bone tumor consisting of mononuclear stromal cells, macrophages, and osteoclast-like giant...
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Establishment and characterization of two novel patient-derived cell lines from giant cell tumor of bone
Giant cell tumor of bone (GCTB) is a rare bone tumor with osteolytic features, composed of stromal cells with a monotonous appearance, macrophages,...
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Injectable and Cell-Laden Hydrogel in the Contained Bone Defect Animal Model: A Systematic Review
Background:Due to its high water content and biomimetic properties simulating extracellular matrix (ECM), hydrogels have been used as preferred cell...
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Bone Marrow Nucleated Cells and Bone Marrow-Derived CD271+ Mesenchymal Stem Cell in Treatment of Encephalopathy and Drug-Resistant Epilepsy
The broad spectrum of brain injuries in preterm newborns and the plasticity of the central nervous system prompts us to seek solutions for...
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Handbook of Stem Cell Applications
This handbook reviews the clinical applications of stem cell-based therapy. The book covers the clinical applications of stem cells in cardiovascular...
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Application of mesenchymal stem cell sheet for regeneration of craniomaxillofacial bone defects
Bone defects are among the most common damages in human medicine. Due to limitations and challenges in the area of bone healing, the research field...
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Reactive Oxygen Species Scavenging Hydrogel Regulates Stem Cell Behavior and Promotes Bone Healing in Osteoporosis
Background:Implantation of bone marrow mesenchymal stem cells (BMSCs) is a potential alternative for promoting bone defects healing or...
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Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone
Oncohistones represent compelling evidence for a causative role of epigenetic perturbations in cancer. Giant cell tumours of bone (GCTs) are...
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Comparative effectiveness of mesenchymal stem cell versus bone-marrow mononuclear cell transplantation in heart failure: a meta-analysis of randomized controlled trials
BackgroundThere is no clear evidence on the comparative effectiveness of bone-marrow mononuclear cell (BMMNC) vs. mesenchymal stromal cell (MSC) stem...
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Bone marrow mesenchymal stem cell’s exosomes as key nanoparticles in osteogenesis and bone regeneration: specific capacity based on cell type
Today, communities and their health systems are facing with several challenges associated with the population ageing. Growing number of bone...
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Intra-Bone Bone Marrow Transplantation
BM is very specific tissue with an extensive vascular network, and the injected BM cells into the organism easily enter and join the peripheral...
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Bone morphogenetic protein 4 rescues the bone regenerative potential of old muscle-derived stem cells via regulation of cell cycle inhibitors
BackgroundBone morphogenetic protein 4 (BMP4) promotes the osteogenic differentiation and the bone regenerative potential of muscle-derived stem...
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Osteoclasts at Bone Remodeling: Order from Order
Osteoclasts are multinucleated bone-resorbing cells derived from the monocyte/macrophage lineage. The macrophage colony-stimulating factor/receptor...