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Cytoplasmic mRNA Transport: Adaptors of mRNA Binding to Microtubule Motor Proteins
AbstractThe process of mRNA localization in the cytoplasm involves the directed transport of mRNP particles using the microtubule system. This...
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Cadmium transport by mammalian ATP-binding cassette transporters
Cellular responses to toxic metals depend on metal accessibility to intracellular targets, reaching interaction sites, and the intracellular metal...
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ATP-Dependent Lon Proteases in the Cellular Protein Quality Control System
AbstractThe Protein Quality Control (PQC) system plays a leading role in maintaining the safety of the cellular proteome in all natural kingdoms....
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A pyrenoid-localized protein SAGA1 is necessary for Ca2+-binding protein CAS-dependent expression of nuclear genes encoding inorganic carbon transporters in Chlamydomonas reinhardtii
Microalgae induce a CO 2 -concentrating mechanism (CCM) to maintain photosynthetic affinity for dissolved inorganic carbon (Ci) under CO 2 -limiting...
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Neuronal Calcium Sensor-1: A Zinc/Redox-Dependent Protein of Nervous System Signaling Pathways
AbstractIntracellular calcium signaling is involved in regulating the key functional mechanisms of the nervous system. The control of neuronal...
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Multivalent interactions facilitate motor-dependent protein accumulation at growing microtubule plus-ends
Growing microtubule ends organize end-tracking proteins into comets of mixed composition. Here using a reconstituted fission yeast system consisting...
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Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport
The lissencephaly-related protein LIS1 is a critical regulator of cytoplasmic dynein that governs motor function and intracellular localization (for...
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Structural Insights into the Lipopolysaccharide Transport (Lpt) System as a Novel Antibiotic Target
Lipopolysaccharide (LPS) is a critical component of the extracellular leaflet within the bacterial outer membrane, forming an effective physical...
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Integration of nuclear Ca2+ transients and subnuclear protein shuttling provides a novel mechanism for the regulation of CREB-dependent gene expression
Nuclear Ca 2+ waves elicited by NMDAR and L-type voltage-gated Ca 2+ -channels as well as protein transport from synapse-to-nucleus are both...
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NF-κB1 p50 stabilizes HIF-1α protein through suppression of ATG7-dependent autophagy
The function and underlying mechanisms of p50 in the regulation of protein expression is much less studied because of its lacking of transactivation...
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Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon
Secretion systems are protein export machines that enable bacteria to exploit their environment through the release of protein effectors. The Type 9...
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Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol
Amyloid β is considered a key player in the development and progression of Alzheimer’s disease (AD). Many studies investigating the effect of statins...
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Forskolin Enhances Antitumor Effect of Oncolytic Measles Virus by Promoting Rab27a Dependent Vesicular Transport System
The measles vaccine virus strain (MV-Edm) serves as a potential platform for the development of effective oncolytic vectors. Nevertheless, despite...
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Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b
BackgroundThe trafficking of cargoes from endosomes to the trans -Golgi network requires numerous sequential and coordinated steps. Cargoes are...
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Crystal structure and metal binding properties of the periplasmic iron component EfeM from Pseudomonas syringae EfeUOB/M iron-transport system
EfeUOB/M has been characterised in Pseudomonas syringae pathovar. syringae as a novel type of ferrous-iron transporter, consisting of an...
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How is a Zinc Ion Correctly Allocated to a Zinc-dependent Protein?
This book chapter tries to visualize how a bacterial cell manages to bring zinc and no other transition metal cation to a zinc-dependent protein....
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Autophagy initiation triggers p150Glued–AP-2β interaction on the lysosomes and facilitates their transport
The endocytic adaptor protein 2 (AP-2) complex binds dynactin as part of its noncanonical function, which is necessary for dynein-driven...
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Calcium-dependent protein kinases CPK21 and CPK23 phosphorylate and activate the iron-regulated transporter IRT1 to regulate iron deficiency in Arabidopsis
Iron (Fe) is an essential micronutrient for all organisms. Fe availability in the soil is usually much lower than that required for plant growth, and...
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Arabidopsis cyclophilins direct intracellular transport of mobile mRNA via organelle hitchhiking
Plants convert external cues into mobile mRNAs to synchronize meristematic differentiation with environmental dynamics. These mRNAs are selectively...
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Substrate binding and inhibition of the anion exchanger 1 transporter
Anion exchanger 1 (AE1), a member of the solute carrier (SLC) family, is the primary bicarbonate transporter in erythrocytes, regulating pH levels...
