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Characterization of bifunctional alginate lyase Aly644 and antimicrobial activity of enzymatic hydrolysates
AbstractAn alginate lyase gene aly644 encoding a member of polysaccharide lyase family 6 was obtained from a metagenome of Antarctic...
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Bifunctional peptides as alternatives to copper-based formulations to control citrus canker
AbstractCitrus canker is an infectious bacterial disease and one of the major threats to the orange juice industry, a multibillion-dollar market that...
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A bifunctional selectable marker for wheat transformation contributes to the characterization of male-sterile phenotype induced by a synthetic Ms2 gene
Key messageAn engineered selectable marker combining herbicide resistance and yellow fluorescence contributes to the characterization of male-sterile...
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A bifunctional fusion protein protected against diabetic nephropathy by suppressing NLRP3 activation
AbstractDiabetic nephropathy (DN), the principal pathogeny of end-stage renal disease (ESRD), is related to metabolic disorders, chronic...
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A bifunctional molecule-assisted synthesis of mimics for use in probing the ubiquitination system
Ubiquitination regulates almost every life process of eukaryotes. The study of the ubiquitin (Ub) coupling or decoupling process and the interaction...
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Mathematical kinetic modelling followed by in vitro and in vivo assays reveal the bifunctional rice GTPCHII/DHBPS enzymes and demonstrate the key roles of OsRibA proteins in the vitamin B2 pathway
BackgroundRiboflavin is the precursor of several cofactors essential for normal physical and cognitive development, but only plants and some...
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Bifunctional and monofunctional α-neoagarooligosaccharide hydrolases from Streptomyces coelicolor A3(2)
AbstractAgar is a galactan and a major component of the red algal cell wall. Agar is metabolized only by specific microorganisms. The final step of...
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A GDPase/UDPase bifunctional enzyme from Candida albicans: purification and biochemical characterization
The most frequently isolated human fungal pathogen is Candida albicans which is responsible for about 50% of all Candida infections. In healthy...
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Hyaluronic acid-binding insulin-like growth factor-1: Creation of a gene encoding a bifunctional fusion protein
Chondrogenic growth factors are promising therapeutic agents for articular cartilage repair. A persistent impediment to fulfilling this promise is a...
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Identification of a novel bifunctional uracil DNA glycosylase from Thermococcus barophilus Ch5
AbstractGenomes of hyperthermophiles are facing a severe challenge due to increased deamination rates of cytosine induced by high temperature, which...
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Bifunctional protein ArsRM contributes to arsenite methylation and resistance in Brevundimonas sp. M20
BackgroundArsenic (As) with various chemical forms, including inorganic arsenic and organic arsenic, is the most prevalent water and environmental...
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Exploring the Molecular Basis of Substrate and Product Selectivities of Nocardicin Bifunctional Thioesterase
d -amino acid introduction in peptides can enrich their biological activities and pharmacological properties as potential drugs. This achievement of...
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Selective inhibition of the amyloid matrix of Escherichia coli biofilms by a bifunctional microbial metabolite
The propensity of bacteria to grow collectively in communities known as biofilms and their ability to overcome clinical treatments in this condition...
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Dynamic evolution of the mTHF gene family associated with primary metabolism across life
BackgroundThe folate cycle of one-carbon (C1) metabolism, which plays a central role in the biosynthesis of nucleotides and amino acids, demonstrates...
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Biochemical characterization of a novel bifunctional chitosanase from Paenibacillus barengoltzii for chitooligosaccharide production
A novel chitosanase gene, designated as PbCsn8 , was cloned from Paenibacillus barengoltzii . It shared the highest identity of 73% with the glycoside...
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Complete genome sequence of Pseudomonas stutzeri S116 owning bifunctional catalysis provides insights into affecting performance of microbial fuel cells
BackgroundPseudomonas stutzeri S116 is a sulfur-oxidizing bacteria isolated from marine sludge. It exhibited excellent electricity generation as...
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In Vitro Assays for the Bifunctional Acylpeptide Hydrolase (APEH) Enzyme from Antarctic Fish
The bifunctional enzyme acylpeptide hydrolase (APEH) is involved in important metabolic processes both as an exopeptidase and as an endopeptidase....
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Catalase from the Antarctic Fungus Aspergillus fumigatus I-9–Biosynthesis and Gene Characterization
Extremely cold habitats are a serious challenge for the existing there organisms. Inhabitants of these conditions are mostly microorganisms and lower...
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Murine deficiency of peroxisomal l-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis
Peroxisomes play an essential role in the β-oxidation of dicarboxylic acids (DCAs), which are metabolites formed upon ω-oxidation of fatty acids....
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Regulation of Gene Expression in Prokaryotes
Information encoded in genes gets translated into proteins. Not all proteins are always required at equal quantity. Therefore, the protein synthesis...