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Comparative assessment of different anti-CD147/Basigin 2 antibodies as a potential therapeutic anticancer target by molecular modeling and dynamic simulation
Cluster of differentiation 147 (CD147) is an attractive target for anticancer therapy since it is pivotal in develo** and progressing several of...
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The tertiary structure of the human Xkr8–Basigin complex that scrambles phospholipids at plasma membranes
Xkr8–Basigin is a plasma membrane phospholipid scramblase activated by kinases or caspases. We combined cryo-EM and X-ray crystallography to...
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PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum
The most severe form of malaria is caused by Plasmodium falciparum . These parasites invade human erythrocytes, and an essential step in this process...
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SARS-CoV-2 Receptors and Their Involvement in Cell Infection
AbstractThe new coronavirus infection (COVID-19) pandemic caused by SARS-CoV-2 has many times surpassed the epidemics caused by SARS-CoV and...
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Size-exclusion chromatography combined with DIA-MS enables deep proteome profiling of extracellular vesicles from melanoma plasma and serum
Extracellular vesicles (EVs) are important players in melanoma progression, but their use as clinical biomarkers has been limited by the difficulty...
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Molecular and biological factors in the prognosis of head and neck squamous cell cancer
The objective of the review is to summarize available literary data on the role and prognostic value of molecular biological markers p53, UBE2C,...
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Cell Cycle Regulation in Mammalian Germ Cells
Meiosis is a unique form of cellular division by which a diploid cell produces genetically distinct haploid gametes. Initiation and regulation of...
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Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology
Solute carriers form one of three major superfamilies of membrane transporters in humans, and include uniporters, exchangers and symporters....
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The rete mirabile: a possible control site for swimbladder function
In a recent study, a large number of transport proteins was detected in the transcriptome and proteome of saline perfused rete mirabile tissue of the...
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CD147 Plasma Levels in Hospitalised Patients with Covid-19 Pneumonia Predict Illness Severity and In-Hospital Mortality
COVID-19 and infectious diseases have been included in strategic development goals (SDG) of United Nations (UN). The CD147 receptor is one of several...
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Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases
Cellular membranes function as permeability barriers that separate cells from the external environment or partition cells into distinct compartments....
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Human Red Blood Cell (RBC) Blood Groups System
Understanding of the blood group system of human gives benefits in transplantation and transfusion medicine. Karl Landsteiner received Noble Prize in...
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Differential Glycoform Analysis of MUC1 Derived from Biological Specimens Using an Antibody-Overlay Lectin Microarray
The association between altered glycosylation of MUC1 and various disease events has sparked significant interest. However, analytical technologies...
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The Onset of Intussusceptive Angiogenesis in COVID-19 Patients Might Come from the Mobilization of Stem Cell Sub-Populations Expressing the Hemangioblast Marker CD143
COVID-19 and infectious diseases have been included in strategic development goals (SDG) of United Nations (UN). The SARS-CoV-2 pandemic has unveiled...
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SARS-CoV-2 S protein activates NLRP3 inflammasome and deregulates coagulation factors in endothelial and immune cells
BackgroundHyperinflammation, hypercoagulation and endothelial injury are major findings in acute and post-COVID-19. The SARS-CoV-2 S protein has been...
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Cellular host factors for SARS-CoV-2 infection
The coronavirus disease 2019 (COVID-19) pandemic has claimed millions of lives and caused a global economic crisis. No effective antiviral drugs are...
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Neurotropism as a Mechanism of the Damaging Action of Coronavirus
Abstract —Clinical evidence suggests that COVID-19 is accompanied by many symptoms of damage to the central and peripheral nervous system. This...
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Non-ABO Blood Group Systems
After the ABO blood group discovery, Karl Landsteiner and his colleagues further discovered additional markers of blood groups of MN and P, and a...