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Baicalin attenuates aflatoxin B1-induced hepatotoxicity via suppressing c-Jun-N-terminal kinase-mediated cell apoptosis
Aflatoxin B 1 (AFB 1 ) is classified as a Class I carcinogen and common pollutant in human and animal food products. Prolonged exposure to AFB 1 can...
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Probiotic cocktails accelerate baicalin metabolism in the ileum to modulate intestinal health in broiler chickens
BackgroundBaicalin and probiotic cocktails are promising feed additives with broad application prospects. While probiotic cocktails are known to...
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Rotenone-induced oxidative stress in THP-1 cells: biphasic effects of baicalin
BackgroundSeveral results demonstrated that microglia and peripheral monocytes/macrophages infiltrating the central nervous system (CNS) are involved...
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Baicalin can enhance odonto/osteogenic differentiation of inflammatory dental pulp stem cells by inhibiting the NF-κB and β-catenin/Wnt signaling pathways
BackgroundScutellaria baicalensis Georgi is a famous traditional Chinese medicine, which is widely used in treating fever, upper respiratory tract...
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Synergistic Effects of Baicalin and Levofloxacin Against Hypervirulent Klebsiella pneumoniae Biofilm In Vitro
Hypervirulent Klebsiella pneumoniae (hvKp) strains that form biofilms have recently emerged worldwide; however, the mechanisms underlying biofilm...
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The effect of a static magnetic field and baicalin or baicalein interactions on amelanotic melanoma cell cultures (C32)
BackgroundBaicalin and baicalein have antioxidant, anti-inflammatory, hepatoprotective and anti-cancer properties. However, it is not known how a...
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Baicalin attenuates adriamycin-induced nephrotic syndrome by regulating fibrosis procession and inflammatory reaction
BackgroundBaicalin has anti-inflammatory, antibacterial, blood platelet aggregation-inhibiting, free oxygen radical-clearing, and...
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Baicalin alleviates lipopolysaccharide-induced neuroglial activation and inflammatory factors activation in hippocampus of adult mice
Baicalin is a natural flavonoid that exerts a variety of pharmaceutical effects such as anti-inflammatory and antioxidant. Lipopolysaccharide (LPS)...
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Unlocking the potential: Baicalin's apoptosis-reducing power and activation of NRF2/P62 for alleviating diabetic cardiomyopathy in rats
BackgroundBaicalin has been proven to have the potential to reduce apoptosis and diabetic cardiomyopathy (DCM). However, the mechanism behind this...
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Scutellaria baicalensis enhances 5-fluorouracil-based chemotherapy via inhibition of proliferative signaling pathways
Fluoropyridine-based chemotherapy remains the most widely used treatment for colorectal cancer (CRC). In this study, we investigated the mechanism by...
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Baicalin suppresses the cell cycle progression and proliferation of prostate cancer cells through the CDK6/FOXM1 axis
The aim of this study was to investigate the effects and mechanisms of baicalin against prostate cancer cell growth and cell cycle progression....
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Protective effect of baicalin on the regulation of Treg/Th17 balance, gut microbiota and short-chain fatty acids in rats with ulcerative colitis
Baicalin is reported as an effective drug for ulcerative colitis (UC). However, its effect on gut microbiota and short-chain fatty acids (SCFAs)...
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The effect of baicalin on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Haemophilus parasuis
Glässer’s disease, caused by Haemophilus parasuis ( H. parasuis ), is associated with vascular damage and vascular inflammation in pigs. Therefore,...
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Characterization of UDP-glycosyltransferase family members reveals how major flavonoid glycoside accumulates in the roots of Scutellaria baicalensis
BackgroundFlavonoid glycosides extracted from roots of Scutellaria baicalensis exhibit strong pharmaceutical antitumor, antioxidative,...
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RETRACTED ARTICLE: Baicalin augments the differentiation of osteoblasts via enhancement of microRNA-217
Baicalin (BAI), a sort of flavonoid monomer, acquires from Scutellaria baicalensis Georgi, which was forcefully reported in diversified ailments due...
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Baicalin ameliorates lupus autoimmunity by inhibiting differentiation of Tfh cells and inducing expansion of Tfr cells
Baicalin is a natural compound isolated from Chinese herb, which has been reported as an anti-inflammatory drug. Here, we demonstrated that Baicalin...
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Baicalin induced colon cancer cells apoptosis through miR-217/DKK1-mediated inhibition of Wnt signaling pathway
To analyze the anti-tumor mechanism of Baicalin in human colon cancer. The MTT assay and colony formation assay demonstrated that Baicalin treatment...
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Molecular dynamics and structure-based virtual screening and identification of natural compounds as Wnt signaling modulators: possible therapeutics for Alzheimer’s disease
Wnt signaling pathway is an evolutionarily conserved pathway responsible for neurogenesis, axon outgrowth, neuronal polarity, synapse formation, and...
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Assessment of the Phytochemical Constituents and Metabolites in the Medicinal Plants and Herbal Medicine Used in the Treatment and Management of Respiratory Diseases
Worldwide, chronic obstructive pulmonary disease, asthma, lung cancer, and cystic fibrosis are some of the top causes of death and morbidity. As a...