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A Baeyer-Villiger monooxygenase from Cupriavidus basilensis catalyzes asymmetric synthesis of (R)-lansoprazole and other pharmaco-sulfoxides
AbstractBiocatalytic synthesis of pharmaco-chiral sulfoxides has gained interest in recent years for its environmental friendliness. However, only a...
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Indigo production goes green: a review on opportunities and challenges of fermentative production
Indigo is a widely used dye in various industries, such as textile, cosmetics, and food. However, traditional methods of indigo extraction and...
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Biocatalytic production of Ɛ-caprolactone using Geotrichum candidum cells immobilized on functionalized silica
AbstractImmobilization of the Geotrichum candidum (CCT 1205) cell with functionalized silica creates promising biocatalysts for production of...
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Biotransformation of bisphenol F by white-rot fungus Phanerochaete sordida YK-624 under non-ligninolytic condition
AbstractEnvironmental bisphenol F (BPF) has a cyclic endocrine disruption effect, seriously threatening animal and human health. It is frequently...
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Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs
Flavin-containing monooxygenases (FMOs) are ubiquitous in all domains of life and metabolize a myriad of xenobiotics, including toxins, pesticides...
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Metagenomic analysis reveals specific BTEX degrading microorganisms of a bacterial consortium
Petroleum hydrocarbon contamination is of environmental and public health concerns due to its toxic components. Bioremediation utilizes microbial...
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Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene
Global control of the tuberculosis epidemic is threatened by increasing prevalence of drug resistant M. tuberculosis isolates. Many genome-wide...
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Differential gene expression of Hymenoscyphus fraxineus grown on Fraxinus excelsior and F. mandshurica supplemented media
Ash dieback is caused by the invasive fungal species Hymenoscyphus fraxineus and leads to the loss of the common ash ( Fraxineus excelsior ) in many...
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Genome mining of Burkholderia ambifaria strain T16, a rhizobacterium able to produce antimicrobial compounds and degrade the mycotoxin fusaric acid
Burkholderia ambifaria T16 is a bacterium isolated from the rhizosphere of barley plants that showed a remarkable antifungal activity. This strain...
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Diversity and metagenome analysis of a hydrocarbon-degrading bacterial consortium from asphalt lakes located in Wietze, Germany
The pollution of terrestrial and aquatic environments by petroleum contaminants, especially diesel fuel, is a persistent environmental threat...
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Enzyme Identification and Screening: Activity-Based Methods
Methods for the identification and characterization of “ideal” enzymes for industrial use in the field of biotechnology have developed rapidly in...
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Initial characterization of an iron superoxide dismutase from Thermobifida fusca
Superoxide dismutases (SODs) are enzymes that catalyze the dismutation of the superoxide radical anion into O 2 and H 2 O 2 in a two-step reaction. They...
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North Sea spring bloom-associated Gammaproteobacteria fill diverse heterotrophic niches
BackgroundThe planktonic bacterial community associated with spring phytoplankton blooms in the North Sea is responsible for a large amount of carbon...
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Nortriterpenes, chromones, anthraquinones, and their chemosystematics significance in Meliaceae, Rutaceae, and Simaroubaceae (Sapindales)
In this review, our analyses of the metabolic routes of limonoids and quassinoids—with respect to their occurrence in the families Rutaceae,...
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Enterobacter cloacae-mediated polymer biodegradation: in-silico analysis predicts broad spectrum degradation potential by Alkane monooxygenase
Plastic pollution poses a significant environmental challenge. In this study, the strain Enterobacter cloacae O5-E, a bacterium displaying...
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The important role of P450 monooxygenase for the biosynthesis of new benzophenones from Cytospora rhizophorae
Benzophenones are polyketides with diverse biological activities. Novel cytotoxic benzophenones cytosporaphenones A-C and cytorhizins A-D, which...
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Flavin-dependent N-hydroxylating enzymes: distribution and application
Amino groups derived from naturally abundant amino acids or (di)amines can be used as “shuttles” in nature for oxygen transfer to provide...
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Limonoids from the genus Trichilia and biological activities: review
Limonoids, present in the families Meliaceae and Rutaceae, provide the bitter principles in citrus and are derived from limonin (first isolated...
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Actinobacteria from Arid Environments and Their Biotechnological Applications
Actinobacteria are a large group of beneficial Gram-positive bacteria that play an important role in sustainable biotechnology. Desert, as a...