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Bacterial matrix metalloproteases and serine proteases contribute to the extra-host inactivation of enteroviruses in lake water
Enteroviruses are ubiquitous contaminants of surface waters, yet their fate in presence of microbial congeners is poorly understood. In this work, we...
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Extracellular proteases from halophiles: diversity and application challenges
AbstractHalophilic extracellular proteases offer promising application in various fields. Information on these prominent proteins including the...
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A comprehensive review on human disease—causing bacterial proteases and their impeding agents
Proteases are enzymes that catalyze the amide bond dissociation in polypeptide and protein peptide units. They are categorized into seven families...
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Integrins as Receptors for Bacterial and Viral Pathogens
Integrins are important cell surface receptors named cell adhesion molecules that mediate cell–cell, cell–matrix, and cell–pathogen interactions....
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On the role of bacterial metalloproteases in COVID-19 associated cytokine storm
The cytokine release syndrome or cytokine storm, which is the hyper-induction of inflammatory responses has a central role in the mortality rate of...
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Protease activities of vaginal Porphyromonas species disrupt coagulation and extracellular matrix in the cervicovaginal niche
Porphyromonas asaccharolytica and Porphyromonas uenonis are common inhabitants of the vaginal microbiome, but their presence has been linked to...
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Zymogram Analysis and Identification of the Extracellular Proteases from Bacillus velezensis SW5
AbstractBacillus velezensis is regarded as a potential starter culture for food, due to its biological safety and efficient protein hydrolysis...
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The use of combination therapy for the improvement of colistin activity against bacterial biofilm
Colistin is used as a last resort for the management of infections caused by multi-drug resistant (MDR) bacteria. However, the use of this antibiotic...
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Extracellular vesicles derived from human foreskin cells (hFS-Exo) accelerate cell migration and angiogenesis through MAPK pathway: an in vitro study
BackgroundWound healing is one of the important processes in the body. Attempts to create new drugs are of interest due to the side effects of...
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Panproteome Analysis of the Human Antibody Response to Bacterial Vaccines and Challenge
High-density protein microarray is an established technology for characterizing host antibody profiles against entire pathogen proteomes. As one of...
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Coral mucus rapidly induces chemokinesis and genome-wide transcriptional shifts toward early pathogenesis in a bacterial coral pathogen
Elevated seawater temperatures have contributed to the rise of coral disease mediated by bacterial pathogens, such as the globally distributed Vibrio...
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Bacterial biocontrol of vibriosis in shrimp: A review
Vibriosis is a disease that frequently infects shrimp and financially devastates the shrimp industry worldwide. Because of the detrimental effects of...
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Association of Sonic Hedgehog with the extracellular matrix requires its zinc-coordination center
BackgroundSonic Hedgehog (Shh) has a catalytic cleft characteristic for zinc metallopeptidases and has significant sequence similarities with some...
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Novel marine metalloprotease—new approaches for inhibition of biofilm formation of Stenotrophomonas maltophilia
AbstractMany marine organisms produce bioactive molecules with unique characteristics to survive in their ecological niches. These enzymes can be...
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IgA1 Protease as a Vaccine Basis for Prevention of Bacterial Meningitis
AbstractThe review covers the study of the protective properties of IgA1 protease and the possibility of creating a vaccine preparation for the...
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Cleavage of cell junction proteins as a host invasion strategy in leptospirosis
AbstractInfection and invasion are the prerequisites for develo** the disease symptoms in a host. While the probable mechanism of host invasion and...
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Production and Characterization of Photorin, a Novel Proteinaceous Protease Inhibitor from the Entomopathogenic Bacteria Photorhabdus laumondii
AbstractEntomopathogenic bacteria of the genus Photorhabdus secrete protease S (PrtS), which is considered a virulence factor. We found that in the Photorhabdus...
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Expression of macromolecular organic nitrogen degrading enzymes identifies potential mediators of soil organic N availability to an annual grass
Nitrogen (N) is frequently limiting to plant growth, in part because most soil N is present as polymeric organic compounds that are not readily taken...
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Adhesion of anaerobic periodontal pathogens to extracellular matrix proteins
Extracellular matrix (ECM) proteins are highly abundant in the human body and can be found in various tissues, most prominently in connective tissue...
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Proteases from the marine bacteria in the genus Pseudoalteromonas: diversity, characteristics, ecological roles, and application potentials
Bacterial strains of the genus Pseudoalteromonas, which includes 48 species, are widely distributed in various ocean environments. Many strains are...
