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Translational landscape of direct cardiac reprogramming reveals a role of Ybx1 in repressing cardiac fate acquisition
Direct reprogramming of fibroblasts into induced cardiomyocytes (iCMs) holds great promise for heart regeneration. Although considerable progress has...
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Acute conversion of patient-derived Duchenne muscular dystrophy iPSC into myotubes reveals constitutive and inducible over-activation of TGFβ-dependent pro-fibrotic signaling
BackgroundIn Duchenne muscular dystrophy (DMD), DYSTROPHIN deficiency exposes myofibers to repeated cycles of contraction/degeneration, ultimately...
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Stem Cell Applications in Cardiac Tissue Regeneration
Cardiovascular pathologies are the leading cause of morbidity and mortality worldwide. While heart transplant remains the gold standard, it is...
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Rational design of stapled helical peptides as antidiabetic PPARγ antagonists to target coactivator site by decreasing unfavorable entropy penalty instead of increasing favorable enthalpy contribution
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor belonging to the nuclear hormone receptor and has...
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Current Developments of Electroconductive Scaffolds for Cardiac Tissue Engineering
Cardiovascular damage and diseases are associated with the leading cause of mortality worldwide. Treatments for cardiovascular damage are limited...
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Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate
Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin...
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Chromatin Remodeling and Cardiac Differentiation of Stem Cells
Cell fate commitment is achieved by cell type-specific transcription, which in turn is guided by epigenetic mechanisms. Epigenetic and chromatin...
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Current Developments of Electroconductive Scaffolds for Cardiac Tissue Engineering
Cardiovascular damage and diseases are associated with the leading cause of mortality worldwide. Treatments for cardiovascular damage are limited...
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Prmt7 promotes myoblast differentiation via methylation of p38MAPK on arginine residue 70
MyoD functions as a master regulator to induce muscle-specific gene expression and myogenic differentiation. Here, we demonstrate a positive role of...
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A neurodevelopmental epigenetic programme mediated by SMARCD3–DAB1–Reelin signalling is hijacked to promote medulloblastoma metastasis
How abnormal neurodevelopment relates to the tumour aggressiveness of medulloblastoma (MB), the most common type of embryonal tumour, remains...
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Reprograming Fibroblasts for Cardiomyocytes and Progenitors
The search for cell-based strategies to repair the injured heartHeart after ischemic injury has led to the discovery of methods for geneticGenetics...
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Development of the Cardiomyocyte
HeartHeart is one of the first organs formed in the develo** foetus. Heart developmentHeart development begins after embryo gastrulation when the...
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SWI/SNF Chromatin Remodelers: Structural, Functional and Mechanistic Implications
The nuclear events of a eukaryotic cell, such as replication, transcription, recombination and repair etc. require the transition of the compactly...
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Linc-RAM promotes muscle cell differentiation via regulating glycogen phosphorylase activity
Long non-coding RNAs (lncRNAs) are important regulators of diverse biological processes, especially skeletal muscle cell differentiation. Most of the...
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Mesenchymal Stem Cells for Cardiac Regeneration: from Differentiation to Cell Delivery
Mesenchymal stem cells (MSCs) are so far the most widely researched stem cells in clinics and used as an experimental cellular therapy module,...
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Molecular regulation of myocardial proliferation and regeneration
Heart regeneration is a fascinating and complex biological process. Decades of intensive studies have revealed a sophisticated molecular network...
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Swimming exercise with l-arginine coated nanoparticles supplementation upregulated HAND2 and TBX5 expression in the cardiomyocytes of aging male rats
We investigated possible cardioprotective mechanisms of l -arginine coated nanoparticles (L-ACN) combined with swimming exercise (SE) in aging male...
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LncRNA CARMN inhibits abdominal aortic aneurysm formation and vascular smooth muscle cell phenotypic transformation by interacting with SRF
Phenotypic transformation of vascular smooth muscle cells (VSMCs) plays a crucial role in abdominal aortic aneurysm (AAA) formation. CARMN, a highly...
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Role of the SWI/SNF Chromatin Remodeling Complex in Regulation of Inflammation Gene Expression
AbstractThe process of inflammation is the body’s natural defense response to the penetration of foreign substances and molecules from the outside....
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Epigenetic regulation of retinal development
In the develo** vertebrate retina, retinal progenitor cells (RPCs) proliferate and give rise to terminally differentiated neurons with exquisite...
