Search
Search Results
-
N6-methyladenosine-modified USP13 induces pro-survival autophagy and imatinib resistance via regulating the stabilization of autophagy-related protein 5 in gastrointestinal stromal tumors
Secondary resistance to imatinib (IM) represents a major challenge for therapy of gastrointestinal stromal tumors (GISTs). Aberrations in oncogenic...
-
Integrated Analysis of Autophagy-Related Genes Identifies Diagnostic Biomarkers and Immune Correlates in Preeclampsia
Preeclampsia (PE) presents a significant challenge in pregnancy due to its high incidence and clinical fatality rate. Previous studies have...
-
Autophagy-related 7 protein-dependent autophagy mediates resveratrol-caused upregulation of mitochondrial biogenesis and steroidogenesis in aged Leydig cell
BackgroundMitochondrial dysfunction may contribute to decreased testosterone synthesis in aged Leydig cells. Resveratrol (RSV) as an antioxidant has...
-
Advances in SIRT3 involvement in regulating autophagy-related mechanisms
The silencing regulatory factor 2-like protein 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD+) dependent deacetylase located primarily in the...
-
Expression of LC3A, LC3B and p62/SQSTM1 autophagy proteins in hepatocellular carcinoma (HCC) tissues and the predicted microRNAs involved in the autophagy-related pathway
BackgroundAutophagy plays multifaceted roles in regulating hepatocellular carcinoma (HCC) and the mechanisms involved are under-explored. Regulatory...
-
Autophagy dysregulation via the USP20-ULK1 axis in the HERC2-related neurodevelopmental disorder
Sequence variants in the HERC2 gene are associated with a significant reduction in HERC2 protein levels and cause a neurodevelopmental disorder known...
-
Establishment and validation of the autophagy-related ceRNA network in irreversible pulpitis
BackgroundThe molecular mechanisms underlying the onset and progression of irreversible pulpitis have been studied for decades. Many studies have...
-
Identification and validation of autophagy-related genes in Kawasaki disease
BackgroundKawasaki disease (KD) is a systemic vasculitis of unknown etiology affecting mainly children. Studies have shown that the pathogenesis of...
-
Curcumin protects against aging-related stress and dysfunction through autophagy activation in rat brain
BackgroundCurcumin ( Curcuma longa ) is a well-known medicinal plant that induces autophagy in various model species, hel** maintain cellular...
-
Construction and validation of a prognostic model based on autophagy-related genes for hepatocellular carcinoma in the Asian population
Background and objectiveHepatocellular carcinoma (HCC), which has a complex pathogenesis and poor prognosis, is one of the most common malignancies...
-
Identification of autophagy-related genes in neuropathic pain through bioinformatic analysis
BackgroundNeuropathic pain (NP) is one of the most common types of chronic pain and significantly compromises the quality of life. Autophagy is an...
-
Crosstalk of cell death pathways unveils an autophagy-related gene AOC3 as a critical prognostic marker in colorectal cancer
The intricate crosstalk of various cell death forms was recently implicated in cancers, laying a foundation for exploring the association between...
-
Regulation of proliferation and apoptosis of aging periodontal ligament cells by autophagy-related gene 7
BackgroundHuman periodontal ligament cells (hPDLCs) can be applied in periodontal regeneration engineering to repair the tissue defects related to...
-
Construction and validation of a bladder cancer risk model based on autophagy-related genes
Autophagy has an important association with tumorigenesis, progression, and prognosis. However, the mechanism of autophagy-regulated genes on the...
-
RNA methylation patterns, immune characteristics, and autophagy-related mechanisms mediated by N6-methyladenosine (m6A) regulatory factors in venous thromboembolism
Recent studies have found a link between deep vein thrombosis and inflammatory reactions. N6-methyladenosine (m6A), a crucial element in...
-
STING agonists as promising vaccine adjuvants to boost immunogenicity against SARS-related coronavirus derived infection: possible role of autophagy
As a major component of innate immunity and a positive regulator of interferons, the Stimulator of interferon gene (STING) has an immunotherapy...
-
Identification of immune-related and autophagy-related genes for the prediction of survival in bladder cancer
BackgroundBladder cancer has the characteristics of high morbidity and mortality, and the prevalence of bladder cancer has been increasing in recent...
-
Observation of increased levels of autophagy-related genes and proteins in women with preeclampsia: a clinical study
BackgroundPreeclampsia is a type of pregnancy-related disease that is not fully understood underlying mechanisms of it till now. Reported results...
-
Hydrogen sulfide inhibits gene expression associated with aortic valve degeneration by inducing NRF2-related pro-autophagy effect in human aortic valve interstitial cells
Aortic valve stenosis (AS) is the most common valvular heart disease but there are currently no effective medical treatments that can delay disease...
-
Development of a risk model based on autophagy-related genes to predict survival and immunotherapy response in ovarian cancer
BackgroundAutophagy is a highly conserved cellular proteolytic process that can interact with innate immune signaling pathways to affect the growth...
