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Methylmalonic acid induces inflammatory response and redox homeostasis disruption in C6 astroglial cells: potential glioprotective roles of melatonin and resveratrol
Methylmalonic acidemia is a neurometabolic disorder biochemically characterized by the accumulation of methylmalonic acid (MMA) in different tissues,...
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Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression
BackgroundSpreading depression (SD) is an intriguing phenomenon characterized by massive slow brain depolarizations that affect neurons and glial...
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Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline
Retinal neurovascular injuries are a leading cause of vision loss in young adults presenting unmet therapeutic needs. Neurovascular injuries damage...
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Assessing Neuronogenic Versus Astrogenic Bias of Neural Stem Cells Via In Vitro Clonal Assay
Within the develo** cerebral cortex, neural stem cells (NSCs) give rise to neurons and glial cells, according to complex spatio-temporal...
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Disturbed Level of Lactate Transporters in Brain Cells during Acute Toxic Effect of β-Amyloid In Vitro and In Vivo
AbstractDecreased brain energy metabolism correlates with cognitive impairment in Alzheimer’s disease. There is accumulating experimental evidence...
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Stable expression of a truncated TLX variant drives differentiation of induced pluripotent stem cells into self-renewing neural stem cells for production of extracellular vesicles
BackgroundNeural stem cells (NSCs)-derived extracellular vesicles (EVs) possess great potential in treating severe neurological and cerebrovascular...
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Stem Cells and Strategies for the Regeneration of the Nervous System
Repairing and regenerating the injured nervous tissue remain a significant challenge that renders patients with permanent functional defects due to...
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Neural Stem Cells
The introduction of neural stem cells (NSCs) from adult mouse brains by Brent Reynold and Samuel Swiss in 1992 not only paved the way for in vitro...
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Neural Stem Cells
The introduction of neural stem cells (NSCs) from adult mouse brains by Brent Reynold and Samuel Swiss in 1992 not only paved the way for in vitro...
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GFAP- and Vimentin-Immunopositive Structures in Human Pineal Gland
AbstractThe pineal gland plays a key role in coordinating various bodily functions. The majority of pineal cells are pinealocytes, and the second...
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D-dopachrome tautomerase drives astroglial inflammation via NF-κB signaling following spinal cord injury
BackgroundReactive astrocytes are increasingly recognized as crucial regulators of innate immunity in degenerative or damaged central nervous system...
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Stem Cells and Strategies for the Regeneration of the Nervous System
Repairing and regenerating the injured nervous tissue remain a significant challenge that renders patients with permanent functional defects due to...
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Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage
BackgroundAlcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health,...
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Cell replacement therapy with stem cells in multiple sclerosis, a systematic review
Multiple sclerosis (MS) is a chronic inflammatory, autoimmune, and neurodegenerative disease of the central nervous system (CNS), characterized by...
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Embryonic stem cells overexpressing high molecular weight FGF2 isoform enhance recovery of pre-ganglionic spinal root lesion in combination with fibrin biopolymer mediated root repair
BackgroundSpinal ventral root avulsion results in massive motoneuron degeneration with poor prognosis and high costs. In this study, we compared...
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Effect of Octamer-Binding Transcription Factor 4 Overexpression on the Neural Induction of Human Dental Pulp Stem Cells
Stem cell-based therapy is a potential alternative strategy for brain repair, with neural stem cells (NSC) presenting as the most promising...
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Cells of Cerebrovascular Endothelium and Perivascular Astroglia in the Regulation of Neurogenesis
AbstractThe blood–brain barrier (BBB) is a constellation of cells within the neurovascular unit of the brain that perform the barrier function, being...
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Methanol fixation is the method of choice for droplet-based single-cell transcriptomics of neural cells
The main critical step in single-cell transcriptomics is sample preparation. Several methods have been developed to preserve cells after dissociation...
