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NOX4-mediated astrocyte ferroptosis in Alzheimer’s disease
This study investigates NADPH oxidase 4 (NOX4) involvement in iron-mediated astrocyte cell death in Alzheimer’s Disease (AD) using single-cell...
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Electroacupuncture prevents astrocyte atrophy to alleviate depression
Astrocyte atrophy is the main histopathological hallmark of major depressive disorder (MDD) in humans and in animal models of depression. Here we...
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Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice
Neuroinflammatory microglia secrete cytokines to induce neurotoxic reactive astrocytes, which are one of the major causes of neuronal death. However,...
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Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity
Astrocytes play a crucial role in regulating sleep–wake behavior, and adenosine signaling is generally thought to be involved. Here we show multiple...
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Kir4.1 channels contribute to astrocyte CO2/H+-sensitivity and the drive to breathe
Astrocytes in the retrotrapezoid nucleus (RTN) stimulate breathing in response to CO 2 /H + , however, it is not clear how these cells detect changes in...
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Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage
BackgroundAlcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health,...
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The cGAS-STING-YY1 axis accelerates progression of neurodegeneration in a mouse model of Parkinson’s disease via LCN2-dependent astrocyte senescence
Recent studies provide clues that astrocyte senescence is correlated with Parkinson’s disease (PD) progression, while little is known about the...
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Astrocyte senescence-like response related to peripheral nerve injury-induced neuropathic pain
BackgroundPeripheral nerve damage causes neuroinflammation, which plays a critical role in establishing and maintaining neuropathic pain (NeP). The...
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A human proteogenomic-cellular framework identifies KIF5A as a modulator of astrocyte process integrity with relevance to ALS
Genome-wide association studies identified several disease-causing mutations in neurodegenerative diseases, including amyotrophic lateral sclerosis...
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Polar lipids modify Alzheimer’s Disease pathology by reducing astrocyte pro-inflammatory signaling through platelet-activating factor receptor (PTAFR) modulation
BackgroundPro-inflammatory processes triggered by the accumulation of extracellular amyloid beta (Aβ) peptides are a well-described pathology in...
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Molecular Mechanisms of Astrocyte Involvement in Synaptogenesis and Brain Synaptic Plasticity
AbstractAstrocytes perform a wide range of important functions in the brain. As structural and functional components of synapses, astrocytes secrete...
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An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis
Cholesterol is an essential membrane structural component and steroid hormone precursor, and is involved in numerous signaling processes. Astrocytes...
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Identification of Ultrastructural Details of the Astrocyte Process System in Nervous Tissue of the Brain Using Correlative Scanning Probe and Transmission Electron Microscopy
AbstractNanoscale morphological features of branched processes of glial cells may be of decisive importance for neuron–astrocyte interactions in...
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Neuron–astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain
Long-lasting pain stimuli can trigger maladaptive changes in the spinal cord, reminiscent of plasticity associated with memory formation. Metabolic...
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Mitochondrial glutamine transporter SLC1A5_var, a potential target to suppress astrocyte reactivity in Parkinson’s Disease
SLC1A5 variant (SLC1A5_var) is identified as a mitochondrial glutamine transporter in cancer cells recently. However, the role of SLC1A5_var in...
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Salidroside promotes the repair of spinal cord injury by inhibiting astrocyte polarization, promoting neural stem cell proliferation and neuronal differentiation
Spinal cord injury (SCI) remains a formidable challenge, lacking effective treatments. Following SCI, neural stem cells (NSCs) migrate to SCI sites,...
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Cntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte–microglia C3-C3aR pathway
Parkinson’s disease (PD) is the most common progressive neurodegenerative movement disorder, which is characterized by dopaminergic (DA) neuron death...
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Glioprotective effects of resveratrol in hypothalamic astrocyte cultures obtained from interferon receptor knockout (IFNα/βR−/−) mice
Astrocytes play essential roles in the central nervous system (CNS), such as the regulation of glutamate metabolism, antioxidant defenses, and...
