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Genome-Wide Association Studies
This detailed collection explores genome-wide association studies (GWAS), which have revolutionized the investigation of complex traits over the past...
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Genome-Wide Association Studies
General methods of genome-wide association studies are introduced: (1) simple regression analysis, (2) mixed model methodology incorporating pedigree...
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Genome-Wide Association Studies (GWAS)
Most of the breeding targets are quantitative traits. In exploring the quantitative trait locus (QTL) system of a trait, linkage map** was...
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Genetic Association Studies in Host-Pathogen Interaction Analysis
Studying host-pathogen interactions at a molecular level has always been technically challenging. Identifying the different biochemical and genetic...
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Variant Selection and Aggregation of Genetic Association Studies in Precision Medicine
Precision medicine provides tailored treatments to patients based on their demographic and genomic profiles, and is a promising approach to improving...
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Genome-Wide Association Studies/SNP Chips
Genome-wide association study (GWA study or GWAS), or whole genome association study (WGA study or WGAS), has been proved to be an effective...
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Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives
Crohn’s disease (CD) is regarded as a lifelong progressive disease affecting all segments of the intestinal tract and multiple organs. Based on...
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Structure-informed clustering for population stratification in association studies
BackgroundIdentifying variants associated with complex traits is a challenging task in genetic association studies due to linkage disequilibrium (LD)...
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Plant Microbiome-Based Genome-Wide Association Studies
Plants form intimate associations with microorganisms, and these associations are directly impacted by the host genotype. However, identifying...
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Genome-Wide Association Studies in Medicago truncatula
Legumes are an integral part of a sustainable agroecosystem for their ability to form symbiosis with nitrogen-fixing rhizobia and deposit a...
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Genome-Wide Association Studies (GWAS) in Cereals
The advent of high-throughput next-generation sequencing technologies in the last decade, coupled with its substantial decrease in cost in the recent...
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Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage
BackgroundThe pathophysiological causes of kidney disease are not fully understood. Here we show that the integration of genome-wide genetic,...
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H3AGWAS: a portable workflow for genome wide association studies
BackgroundGenome-wide association studies (GWAS) are a powerful method to detect associations between variants and phenotypes. A GWAS requires...
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Genome-Wide Association Studies (GWAS) for Agronomic Traits in Maize
Maize is a highly important crop, not only because it is a staple crop for humans but also because it is a major source of feed for animals and has...
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A comprehensive comparison of multilocus association methods with summary statistics in genome-wide association studies
BackgroundMultilocus analysis on a set of single nucleotide polymorphisms (SNPs) pre-assigned within a gene constitutes a valuable complement to...
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Transcriptome-wide association studies: recent advances in methods, applications and available databases
Genome-wide association study has identified fruitful variants impacting heritable traits. Nevertheless, identifying critical genes underlying those...
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Unsupervised deep representation learning enables phenotype discovery for genetic association studies of brain imaging
Understanding the genetic architecture of brain structure is challenging, partly due to difficulties in designing robust, non-biased descriptors of...
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Methods for Association Studies
Association studies are a key approach to evaluating the relationship between genetic factors and phenotypes or traits. This chapter presents general...
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Trait Based Association Map** in Plants
Genome-wide association studies (GWAS) estimate the likelihood of association between genotype and phenotype in any large collection of material and...
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The Association Between Antioxidants and COVID-19 Outcomes: a Systematic Review on Observational Studies
It is proven that the blood concentration of antioxidants can impress the severity of viral infections, including COVID-19. However, the lack of a...
