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Apoptotic cell death in disease—Current understanding of the NCCD 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that...
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Genetics of Programmed Cell Death
To live or die is a fundamental question for all organisms. It is also a critical issue at the level of individual cells of an organism. Programmed...
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An arresten-derived anti-angiogenic peptide triggers apoptotic cell death in endothelial cells
BackgroundIn recent years, anti-angiogenic peptides have received considerable attention as candidates for cancer treatment. Arresten is an...
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Latex C-serum from Hevea brasiliensis induces apoptotic cell death in a leukemic cell line
BackgroundHevea brasiliensis latex is generally cultivated for the use of rubber particles. Previous studies have shown that the antiproliferative...
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Loss of Paip1 causes translation reduction and induces apoptotic cell death through ISR activation and Xrp1
Regulation of protein translation initiation is tightly associated with cell growth and survival. Here, we identify Paip1 , the Drosophila homolog of...
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Influenza viral matrix 1 protein aggravates viral pathogenicity by inducing TLR4-mediated reactive oxygen species production and apoptotic cell death
Influenza virus is one of the most challenging viruses threating human health. Since infection with influenza virus triggers inflammatory responses...
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Cell Death in Photoautotrophs
Programmed cell death (PCD) is a genetically controlled mechanism regulating cellular demise. Though commonly associated with multicellular...
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Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death
In humans, most neurons are born during embryonic development and have to persist throughout the entire lifespan of an individual. Thus, human...
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High molecular weight hyaluronic acid drastically reduces chemotherapy-induced mucositis and apoptotic cell death
Oral and intestinal mucositis (OIM) are debilitating inflammatory diseases initiated by oxidative stress, resulting in epithelial cell death and are...
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Mitochondria and cell death
Mitochondria are cellular factories for energy production, calcium homeostasis and iron metabolism, but they also have an unequivocal and central...
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Cell Death by Apoptosis
Apoptosis is a phenomenon involving multiple sequential molecular steps that lead to cell death. The intrinsic pathway and extrinsic pathway are two...
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Cell death as an architect of adult skin stem cell niches
Our skin provides a physical and immunological barrier against dehydration and environmental insults ranging from microbial attacks, toxins and UV...
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Autophagy deficiency exacerbates iron overload induced reactive oxygen species production and apoptotic cell death in skeletal muscle cells
Iron overload is associated with various pathological changes which contribute to metabolic syndrome, many of which have been proposed to occur via...
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Enzymatically Formed Oxysterols and Cell Death
The side-chain hydroxylation of cholesterol by specific enzymes produces 24(S)-hydroxycholesterol, 25-hydroxycholesterol, 27-hydroxycholesterol, and...
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When cell death goes wrong: inflammatory outcomes of failed apoptosis and mitotic cell death
Apoptosis is a regulated cellular pathway that ensures that a cell dies in a structured fashion to prevent negative consequences for the tissue or...
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Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death
Mutations in genes encoding general transcription factors cause neurological disorders. Despite clinical prominence, the consequences of defects in...
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Stabilin-2 mediated apoptotic cell phagocytosis induces interleukin-10 expression by p38 and Pbx1 signaling
Apoptotic cell death occurs under normal physiological conditions, such as development, tissue remodeling, and inflammation. Appropriate removal of...
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Identification of a novel form of caspase-independent cell death triggered by BH3-mimetics in diffuse large B-cell lymphoma cell lines
BH3-mimetics represent promising anti-cancer agents in tumors that rely on the anti-apoptotic function of B-Cell Lymphoma 2 (BCL2) proteins,...
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Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth
Chemokinostatin-1 (CKS1) is a 24-mer peptide originally discovered as an anti-angiogenic peptide derived from the CXCL1 chemokine. Here, we...
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Frontier knowledge and future directions of programmed cell death in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is one of the most common renal malignancies of the urinary system. Patient outcomes are relatively poor due...
