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An apoptosis-inducing factor controls programmed cell death and laccase expression during fungal interactions
AbstractApoptotic-like programmed cell death (PCD) is one of the main strategies for fungi to resist environmental stresses and maintain homeostasis....
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Kaempferol sensitizes tumor necrosis factor-related apoptosis-inducing ligand-resistance chronic myelogenous leukemia cells to apoptosis
BackgroundThe tumor necrosis factor (TNF)-related apoptosis-inducing ligand, TRAIL, an apoptosis-inducing cytokine, has attracted much attention in...
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ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis
Z-DNA binding protein 1 (ZBP1) has important functions in anti-viral immunity and in the regulation of inflammatory responses. ZBP1 induces...
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Cucurbitacin-I exhibits anticancer activity by inducing apoptosis in SKOV3 human ovarian cancer cells
BackgroundCucurbitacin-I is a natural cell-permeable triterpenoid compound isolated from Cucurbitaceae and Cruciferae. The pharmacological activity...
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Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis)
ARID1A, a component of the SWI/SNF chromatin-remodeling complex, is frequently mutated in various cancer types and has emerged as a potential...
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Protein tyrosine phosphatase PTPRO represses lung adenocarcinoma progression by inducing mitochondria-dependent apoptosis and restraining tumor metastasis
Emerging evidence indicates that protein activities regulated by receptor protein tyrosine phosphatases (RPTPs) are crucial for a variety of cellular...
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DHA attenuates CAR-T cell efficacy through aggravating exhaustion and inducing apoptosis
Chimeric antigen receptor-modified T cell (CAR-T) therapy is a newly developed adoptive treatment for cancer in recent years that has shown potential...
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Ketoprofen suppresses triple negative breast cancer cell growth by inducing apoptosis and inhibiting autophagy
BackgroundTriple-negative breast cancer (TNBC) is an invasive phenotype with undesirable clinical features, poor prognosis, and therapy resistance....
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Bone morphogenetic protein inhibitors and mitochondria targeting agents synergistically induce apoptosis-inducing factor (AIF) caspase-independent cell death in lung cancer cells
BackgroundBone morphogenetic proteins (BMP) are evolutionarily conserved morphogens that are reactivated in lung carcinomas. In lung cancer cells,...
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Bifidobacterium-derived membrane vesicles inhibit triple-negative breast cancer growth by inducing tumor cell apoptosis
BackgroundBacterial outer membrane vesicles have gained increasing attention for its antitumor effect and application in drug delivery. However, the...
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Iodine-125 seed inhibits proliferation and promotes apoptosis of cholangiocarcinoma cells by inducing the ROS/p53 axis
With advances in radioactive particle implantation in clinical practice, Iodine-125 ( 125 I) seed brachytherapy has emerged as a promising treatment...
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Surfactin inhibits Fusarium graminearum by accumulating intracellular ROS and inducing apoptosis mechanisms
Fusarium graminearum , a devastating fungal pathogen, is the main pathogen of Fusarium head blight (FHB) in wheat globally; it results in significant...
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A biochemical assessment of apoptosis-inducing impact of Salinomycin in combination with ciprofloxacin on human leukemia KG1–a stem-like cells in the presence and absence of insulin
BackgroundAcute Myeloid Leukemia (AML) is a fast-develo** invading cancer that impacts the blood and bone marrow, marked by the rapid proliferation...
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Hepatocyte growth factor-mediated apoptosis mechanisms of cytotoxic CD8+ T cells in normal and cirrhotic livers
Intrahepatic stem/progenitor cells and cytotoxic CD8 + T cells (CD8 + T cells) in the cirrhotic liver undergo apoptosis, which potentially facilitates...
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Mesenchymal stem cell-derived exosomes decrease Hyperplasia in Psoriasis by inducing transforming growth factor β2 (TGF-β2)
BackgroundPsoriasis, a chronic inflammatory skin disease, is increasingly effectively managed with the targeted immunotherapy; however, long-term...
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Systems biology of apoptosis
New approaches are required for the mathematical modelling and system identification of complex signal transduction networks, which are characterized...
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Inducing apoptosis by using microRNA in radio-resistant prostate cancer: an in-silico study with an in-vitro validation
BackgroundOne of the problems with radiation therapy (RT) is that prostate tumor cells are often radio-resistant, which results in treatment failure....
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Molecular characterization and functional analysis of apoptosis-inducing factor (AIF) in palmitic acid-induced apoptosis in Ctenopharyngodon idellus kidney (CIK) cells
Palmitic acid (PA), the most common saturated free fatty acid, may cause apoptosis when overloaded in non-fat cells. Apoptosis-inducing factor (AIF)...
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Galectin-9, a pro-survival factor inducing immunosuppression, leukemic cell transformation and expansion
Leukemia is a malignancy of the bone marrow and blood originating from self-renewing cancerous immature blast cells or transformed leukocytes....
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The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor with a poor median survival of less than 15 months. However, clinical strategies...
