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Discovery and characterization of genes conferring natural resistance to the antituberculosis antibiotic capreomycin
Metagenomic-based studies have predicted an extraordinary number of potential antibiotic-resistance genes (ARGs). These ARGs are hidden in various...
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Naringenin protects hepato-renal tissues against antituberculosis drugs induced toxic manifestations by modulating interleukin-6, insulin like growth factor-1, biochemical and ultra-structural integrity
BackgroundThe antituberculosis drugs (ATDs), isoniazid, rifampicin, pyrazinamide and ethambutol prompt extreme hepatic and renal damage during...
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Mechanisms of Mycobacterium tuberculosis Drug Resistance
AbstractThe review presents the results of investigations of the mechanisms of action of long-used and new antituberculosis drugs, and information...
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Synthesis and Biological Activity of N-Acylhydrazones
Abstract—The synthesis of hybrid molecules that contain fragments of natural compounds and pharmacophore groups makes it possible to develop a wide...
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Isolation, Functionalization, In Silico Investigation, and Synthesis of 1,8-Cineole Analog as Antitubercular Agent Targeting InhA
AbstractA desirable and established target for creating antituberculosis drug lead molecules is the Mycobacterium tuberculosis enoyl-acyl carrier...
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Nanoparticles of Lactic Acid Polymer with Rifampicin Decrease the P-gp Multidrug Transporter Activity in Human Macrophages
Abstract —The problem of reduced effectiveness of antituberculosis drugs is currently associated not only with the development of drug resistance in...
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GenoMycAnalyzer: a web-based tool for species and drug resistance prediction for Mycobacterium genomes
BackgroundDrug-resistant tuberculosis (TB) is a major threat to global public health. Whole-genome sequencing (WGS) is a useful tool for species...
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The Effect of Experimental BCG Antigen–Betulin-Derived Conjugates on the Guinea Pig Immunological Response
AbstractThe immunopotentiating properties of BCG vaccine strain antigen conjugated with betulin derivatives have been evaluated. The experiments were...
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Identification of novel inhibitors for mycobacterial polyketide synthase 13 via in silico drug screening assisted by the parallel compound screening with genetic algorithm-based programs
Identifying small compounds capable of inhibiting Mycobacterium tuberculosis polyketide synthase 13 (Pks13), in charge of final step of mycolic acid...
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Boerhaavia diffusa Extract Acts as a Specific Antituberculosis Agent in Vitro Against Mycobacterium tuberculosis H37Rv Infection
AbstractThe present study investigated Boerhaavia diffusa extract against Mycobacterium tuberculosis H37Rv ( M.tb ) infection in vitro and explored...
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Search for Zinc Complexes with High Affinity in Pyrazinamidase from Mycobacterium Tuberculosis Resistant to Pyrazinamide
Tuberculosis is an ancient and current disease. Resistance to the prodrug pyrazinamide (PZA), one of the most important antituberculosis drug, is...
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Chemical profiling of Streptomyces sp. for detection of potential pharmaceutical molecules
Streptomyces sp. SL-4 which had been isolated and taxonomically characterized during our earlier studies showed promising antibacterial activities....
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Synthesis and biological activity of analogs of CPZEN-45, a novel antituberculosis drug
Analogs of CPZEN-45, which is expected to be a promising new antituberculosis drug that overcomes the shortcomings of caprazamycins, were synthesized...
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Talaromyces Marneffei Infection in an HIV-Negative Child with a CARD9 Mutation in China: A Case Report and Review of the Literature
BackgroundTalaromyces marneffei ( T. marneffei ) is a thermally dimorphic fungus causing systemic mycosis. Due to the atypical symptoms and diverse...
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Antimicrobial Peptides as Immunomodulators and Antimycobacterial Agents to Combat Mycobacterium tuberculosis: a Critical Review
Tuberculosis (TB) is a devastating disease foisting a significantly high morbidity, prepotent in low- and middle-income develo** countries....
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Therapeutic potential of pyrrole and pyrrolidine analogs: an update
The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has been a versatile field of study for a long time for its...
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A morpheein equilibrium regulates catalysis in phosphoserine phosphatase SerB2 from Mycobacterium tuberculosis
Mycobacterium tuberculosis phosphoserine phosphatase Mt SerB2 is of interest as a new antituberculosis target due to its essential metabolic role in...
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Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ
Melanoma is one of the most aggressive skin cancers and 5-year survival rate is only 4.6% for metastatic melanoma patients. Current therapies,...
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cAMP-Dependent Transcription Factor in Mycobacterium tuberculosis Coded by the Rv3676 Gene as a Possible Target for the Development of Antituberculosis Drugs
AbstractAdenylate cyclase Rv2212 plays a key role in the growth of Mycobacterium tuberculosis ( Mtb ) and its reactivation from the dormant state....
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Heliotropium indicum (L.) Boraginaceae
Heliophytum indicum A.D.C.; Tiaridium indicum F.Lehm.; Heliophytum indicum (L.) DC.