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CTCF blocks antisense transcription initiation at divergent promoters
Transcription at most promoters is divergent, initiating at closely spaced oppositely oriented core promoters to produce sense transcripts along with...
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Combined Application of Antisense Oligomers to Control Transcription Factors of Candida albicans Biofilm Formation
Antisense oligomers (ASOs) have been little exploited to control determinants of Candida albicans virulence. Biofilm formation is an important...
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Bi-directional Transcription, Double-Stranded RNA and the Implications on Genome Evolution
Double-stranded RNA (dsRNA) within cells indicates viral infection and triggers a robust innate immune response. Counterintuitively, cells also...
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Transcription directionality is licensed by Integrator at active human promoters
A universal characteristic of eukaryotic transcription is that the promoter recruits RNA polymerase II (RNAPII) to produce both precursor mRNAs...
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OVCH1 Antisense RNA 1 is differentially expressed between non-frail and frail old adults
While some old adults stay healthy and non-frail up to late in life, others experience multimorbidity and frailty often accompanied by a...
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A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression
Antisense RNAs are ubiquitous in human cells, yet their role is largely unexplored. Here we profiled antisense RNAs in the MDA-MB-231 breast cancer...
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IGF2 is upregulated by its antisense RNA to potentiate pancreatic cancer progression
Pancreatic cancer is a deadly cancer. More and more long noncoding RNAs (lncRNAs) have received confirmation to be dysregulated in tumors and exert...
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The pancancer overexpressed NFYC Antisense 1 controls cell cycle mitotic progression through in cis and in trans modes of action
Antisense RNAs (asRNAs) represent an underappreciated yet crucial layer of gene expression regulation. Generally thought to modulate their sense...
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Antisense RNA (asRNA) technology: the concept and applications in crop improvement and sustainable agriculture
Antisense RNA (asRNA) technology is a method used to silence genes and inhibit their expression. Gene function relies on expression, which follows...
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Increased Brucella abortus asRNA_0067 expression under intraphagocytic stressors is associated with enhanced virB2 transcription
Intracellular pathogens like Brucella face challenges during the intraphagocytic adaptation phase, where the modulation of gene expression plays an...
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Antisense lncRNA NNT-AS1 promoted esophageal squamous cell carcinoma progression by regulating its sense gene NNT expression
Antisense lncRNAs were endogenous productions from the antisense strand of coding genes and were transcribed in the reverse direction of the sense...
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Targeting Transcription Factors in Cancer: From “Undruggable” to “Druggable”
Deregulation of transcription factors is critical to hallmarks of cancer. Genetic mutations, gene fusions, amplifications or deletions, epigenetic...
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Natural antisense RNA Foxk1-AS promotes myogenic differentiation by inhibiting Foxk1 activity
BackgroundNatural antisense RNAs are RNA molecules that are transcribed from the opposite strand of either protein-coding or non-protein coding genes...
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Genome-wide view and characterization of natural antisense transcripts in Cannabis Sativa L
Natural Antisense Transcripts (NATs) are a kind of complex regulatory RNAs that play crucial roles in gene expression and regulation. However, the...
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Transcription regulation by long non-coding RNAs: mechanisms and disease relevance
Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions remain largely unknown. In this Review, we discuss the...
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RNA Transcription
The process of producing proteins from nucleotides is termed as gene expression. Genetic information present in the DNA, is first rewritten,...
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The long non-coding RNA keratin-7 antisense acts as a new tumor suppressor to inhibit tumorigenesis and enhance apoptosis in lung and breast cancers
Expression of the long non-coding RNA (lncRNA) keratin-7 antisense (KRT7-AS) is downregulated in various types of cancer; however, the impact of...
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Transcription start site map** and small RNA profiling of Leptospira biflexa serovar Patoc
Leptospirosis is an emerging zoonotic disease caused by bacterial species of the genus Leptospira . However, the regulatory mechanisms and pathways...
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Transfer RNA modifications and DNA editing in HIV-1 reverse transcription
Reverse transcription is a central step in HIV-1 replication that represents a typical case of interplay between viral and cellular factors. HIV-1...
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Detecting R-Loop Formation Using a Plasmid-Based In Vitro Transcription Assay
R-loops are three-stranded nucleic acid structures that consist of a DNA-RNA hybrid and a displaced single-stranded DNA. Since it was first reported...