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Antiaging Strategies Based on Sirtuin Activation
Aging is one of the main risk factor for many diseases and conditions that limit lifespan. The key focus of antiaging research is to explore whether...
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Antiaging agents: safe interventions to slow aging and healthy life span extension
Human longevity has increased dramatically during the past century. More than 20% of the 9 billion population of the world will exceed the age of 60...
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Coenzyme Q as an Antiaging Strategy
Aging is a very complex process in which many factors are involved. As a common factor the accumulation of damaged cell and tissue structures, impair...
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Spermidine, an Autophagy Inducer, as a Therapeutic Antiaging Strategy
Aging is an ineluctable physiological process that occurs in humans and is often known to progress towards death. It is associated with organ...
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Metabolites and novel compounds with anti-microbial or antiaging activities from Cordyceps fumosorosea
High-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) analysis revealed that there are 20 main components in spores and...
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The Role of Telomerase Activators in Antiaging Strategies and their Clinical Potential
Recent studies have focused on telomere shortening for the prevention of cellular aging and diseases related to aging. Re-extension of shortened...
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Elicitation of Pueraria candollei var. mirifica suspension cells promises antioxidant potential, implying antiaging activity
Elicitors that trigger the defense mechanism of plants could be a promising approach for elevating the bioactive compounds in tissue-cultured plant...
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Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways
Compounds with lifespan extension activity are rare, although increasing research efforts have been invested in this field to find ways to extend...
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Empagliflozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress
Sodium-glucose cotransporter-2 (SGLT-2) inhibitors have received widespread attention because of their significant protective effects on the kidney....
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Progress in phosphorylation of natural products
Natural medicines are a valuable resource for the development of new drugs. However, factors such as low solubility and poor bioavailability of...
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RNA-sequencing exploration on SIR2 and SOD genes in Polyalthia longifolia leaf methanolic extracts (PLME) mediated anti-aging effects in Saccharomyces cerevisiae BY611 yeast cells
Polyalthia longifolia is well-known for its abundance of polyphenol content and traditional medicinal uses. Previous research has demonstrated that...
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The meaning of adaptation in aging: insights from cellular senescence, epigenetic clocks and stem cell alterations
With recent rapid progress in research on aging, there is increasing evidence that many features commonly considered to be mechanisms or drivers of...
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Effects of Mannosylerythritol-Lipids-B on Cutibacterium acnes ATCC 6919
Mannosylerythritol-lipids-B (MEL-B) are microbial-produced glycolipids with skincare properties, notably moisturizing, antimelanogenic,...
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Aging is associated with a systemic length-associated transcriptome imbalance
Aging is among the most important risk factors for morbidity and mortality. To contribute toward a molecular understanding of aging, we analyzed...
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Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO
Liangyi Gao (LYG), a traditional Chinese medicine, is composed of Ginseng and Radix Rehmanniae Preparata, both of which have been shown to have...
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Spices as Cosmeceuticals
Plants are known to produce a large number of naturally occurring secondary metabolites, many of them with unique cosmeceutical and pharmacological...
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Astragalus Polysaccharides Reduce High-glucose-induced Rat Aortic Endothelial Cell Senescence and Inflammasome Activation by Modulating the Mitochondrial Na+/Ca2+ Exchanger
Vascular endothelial cells play a vital role in atherosclerotic changes and the progression of cardiovascular disease in older adults. Previous...
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Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium
Degenerative changes of the retinal pigment epithelium (RPE) triggered by transforming growth factor-β2 (TGF-β2) and oxidative stress play a critical...
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Recent progress in research on Momordica charantia polysaccharides: extraction, purification, structural characteristics and bioactivities
Momordica charantia ( M. charantia ), as a common edible vegetable and herb, is mainly distributed in tropical and subtropical regions of the world. M....
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Comprehensive review of the skin use of bakuchiol: physicochemical properties, sources, bioactivities, nanotechnology delivery systems, regulatory and toxicological concerns
Bakuchiol is a meroterpene that has recently aroused great interest in the cosmetic and pharmaceutical industries. Its main source is the seeds of Psor...
