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Emergence of Avian coronavirus Escape Mutants Under Suboptimal Antibody Titers
To perform a quasispecies assessment of the effect of vaccine combinations and antibody titers on the emergence of Avian coronavirus (AvCoV) escape...
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SAF-A mutants disrupt chromatin structure through dominant negative effects on RNAs associated with chromatin
Here we provide a brief review of relevant background before presenting results of our investigation into the interplay between scaffold attachment...
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A computational overview of integrase strand transfer inhibitors (INSTIs) against emerging and evolving drug-resistant HIV-1 integrase mutants
AIDS (Acquired immunodeficiency syndrome) is one of the chronic and potentially life-threatening epidemics across the world. Hitherto, the...
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Infection and protection responses of deletion mutants of non-structural proteins of foot-and-mouth disease virus serotype Asia1 in guinea pigs
The development of a negative marker vaccine against the foot-and-mouth disease virus (FMDV) will enhance the capabilities to differentiate...
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Energy metabolism, anti-oxidant defense and aging in Caenorhabditis elegans
Food restriction and impaired gene function by mutation or RNAi treatment can extend the lifespan of Caenorhabditis elegans considerably. In contrast...
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Protein kinase C is required for the pathogenicity of Setosphaeria turcica on maize
Northern corn leaf blight caused by Setosphaeria turcica is one of the most important fungal diseases of maize. We previously cloned and analyzed the...
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Proteolytic activation of fatty acid synthase signals pan-stress resolution
Chronic stress and inflammation are both outcomes and major drivers of many human diseases. Sustained responsiveness despite mitigation suggests a...
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Mass spectrometry-based proteomics in basic and translational research of SARS-CoV-2 coronavirus and its emerging mutants
Molecular diagnostics of the coronavirus disease of 2019 (COVID-19) now mainly relies on the measurements of viral RNA by RT-PCR, or detection of...
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Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish
The stability of cellular phenotypes in develo** organisms depends on error-free transmission of epigenetic and genetic information during mitosis....
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A pyrenoid-localized protein SAGA1 is necessary for Ca2+-binding protein CAS-dependent expression of nuclear genes encoding inorganic carbon transporters in Chlamydomonas reinhardtii
Microalgae induce a CO 2 -concentrating mechanism (CCM) to maintain photosynthetic affinity for dissolved inorganic carbon (Ci) under CO 2 -limiting...
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Screening and Analysis of Pollen Tube Mutations
Although the cytology of the cellular aspects of male gametophytic development has been very well described for several species, molecular...
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A zebrafish model of growth hormone insensitivity syndrome with immune dysregulation 1 (GHISID1)
Signal transducer and activator of transcription (STAT) proteins act downstream of cytokine receptors to facilitate changes in gene expression that...
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Fungal–bacterial interaction selects for quorum sensing mutants with increased production of natural antifungal compounds
Soil microorganisms coexist and interact showing antagonistic or mutualistic behaviors. Here, we show that an environmental strain of Bacillus subtilis ...
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Small-RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants
PIWI-interacting RNAs (piRNAs) promote fertility in many animals. However, whether this is due to their conserved role in repressing repetitive...
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Analysis of C. elegans Germline Small RNA Pathways
Sequence-specific gene regulation by small RNA (sRNA) pathways is essential for the development and function of organisms in all domains of life....
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Pollen tube invasive growth is promoted by callose
Callose, a β-1,3-glucan, lines the pollen tube cell wall except for the apical growing region, and it constitutes the main polysaccharide in pollen...
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PUB40 attenuates Phytophthora capsici resistance by destabilizing the MEK2-SIPK/WIPK cascade in Nicotiana benthamiana
The mitogen-activated protein kinase (MAPK) cascade MEK2-SIPK/WIPK is essential for immunity in Solanaceae plants. This cascade is tightly controlled...
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Anti-IL-10 Antibody Humanization by SDR Grafting with Enhanced Affinity to Neutralize the Adverse Response of Interleukin-10
The overexpression of IL-10 is associated with numerous diseases like lymphoma, melanoma, systemic lupus erythematosus, systemic sclerosis, and...
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Development of flavivirus subviral particles with low cross-reactivity by mutations of a distinct antigenic domain
AbstractThe most conserved fusion loop (FL) domain present in the flavivirus envelope protein has been reported as a dominant epitope for...
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Interplay between formation of photosynthetic complexes and expression of genes for iron–sulfur cluster assembly in Rhodobacter sphaeroides?
Formation of photosynthetic complexes leads to a higher demand for Fe–S clusters. We hypothesized that in the facultative phototrophic...
