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Angiotensin-(1–9) attenuates adriamycin-induced cardiomyopathy in rats via the angiotensin type 2 receptor
Adriamycin (ADR) causes irreversible damage to the heart, leading to ADR-induced cardiomyopathy (ACM). Angiotensin-(1–9) [Ang-(1–9)] is a peptide...
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Angiotensin receptor blocker use is associated with upregulation of the memory-protective angiotensin type 4 receptor (AT4R) in the postmortem brains of individuals without cognitive impairment
The reported primary dementia-protective benefits of angiotensin II type 1 receptor (AT 1 R) blockers (ARB) are believed, at least in part, to arise...
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Advances in the allostery of angiotensin II type 1 receptor
Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric...
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Fracture Risk and Use of Angiotensin-Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers
Medications used to treat hypertension may affect fracture risk. This study investigated fracture risk for users of angiotensin converting enzyme...
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Interactions of angiotensin-converting enzyme-2 (ACE2) and SARS-CoV-2 spike receptor-binding domain (RBD): a structural perspective
BackgroundSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused millions of infections and deaths worldwide since its discovery in...
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Angiotensin II Type I Receptor—168A/G Polymorphism Is Associated with Increased the Risk of Glioma in Turkish Population
AbstractGliomas are the most common primary tumors of the Central Nervous System. Despite advances in the elucidation of molecular pathogenesis,...
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Non-HLA angiotensin-type-1 receptor autoantibodies mediate the long-term loss of grafted neurons in Parkinson’s disease models
BackgroundClinical trials have provided evidence that transplants of dopaminergic precursors, which may be replaced by new in vitro stem cell...
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Renin angiotensin system-induced muscle wasting: putative mechanisms and implications for clinicians
Renin angiotensin system (RAS) alters various mechanisms related to muscle wasting. The RAS system consists of classical and non-classical pathways,...
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Cisplatin treatment reduces contraction to angiotensin II by altering expression of angiotensin II receptors: a pilot study
The renin angiotensin system is a key regulator of blood pressure homeostasis. Angiotensin type 1 (AT 1 R) and 2 receptors (AT 2 R) have been...
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Association of Angiotensin II Type 1 Receptor (AT1R) Gene Polymorphism with Angiotensin II Serum Levels in Patients with Essential Hypertension
Essential hypertension (EH) is a multifactorial, polygenic condition, and is one of the most important comorbidities that contributes to stroke,...
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ATR1 Angiotensin II Receptor Reduces Hemoglobin S Polymerization, Phosphatidylserine Exposure, and Increases Deformability of Sickle Cell Disease Erythrocytes
Angiotensin II (Ang II) regulates blood volume and stimulates erythropoiesis through AT1 (ATR1) and AT2 (ATR2) receptors, found in multiple tissues,...
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The potential role of renin angiotensin system in acute leukemia: a narrative review
Acute leukemias (ALs) are the most common cancers in pediatric population. There are two types of ALs: acute lymphoblastic leukemia (ALL) and acute...
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Analysis of the Glycoprotein Properties and Glycan Structures of Chicken Angiotensin Converting Enzyme 2
Glycosylation of angiotensin converting enzyme 2 (ACE2), the principal receptor protein of severe scute respiratory syndrome coronavirus 2...
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SARS-CoV-2 cell entry beyond the ACE2 receptor
BackgroundAngiotensin-converting enzyme 2 (ACE2) is known as the major viral entry site for SARS-CoV-2. However, viral tissue tropism and high rate...
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Prostaglandin I2 signaling prevents angiotensin II-induced atrial remodeling and vulnerability to atrial fibrillation in mice
Atrial fibrillation (AF) is the most common arrhythmia, and atrial fibrosis is a pathological hallmark of structural remodeling in AF. Prostaglandin I
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Identification of novel inhibitors of angiotensin-converting enzyme 2 (ACE-2) receptor from Urtica dioica to combat coronavirus disease 2019 (COVID-19)
AbstractThe pandemic outbreak of coronavirus (SARS-CoV-2) is rapidly spreading across the globe, so the development of anti-SARS-CoV-2 agents is...
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Angiotensin II constricts mouse iliac arteries: possible mechanism for aortic aneurysms
Abdominal aortic aneurysms (AAA) result from maladaptive remodeling of the vascular wall and reduces structural integrity. Angiotensin II (AngII)...
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Blocking angiotensin 2 receptor attenuates diabetic nephropathy via mitigating ANGPTL2/TL4/NF-κB expression
BackgroundDiabetic nephropathy (DN) is a consequence of diabetes mellitus (DM) and is associated with early changes in renal angiotensin II (ANG II)....
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Generation of a humanized mAce2 and a conditional hACE2 mouse models permissive to SARS-COV-2 infection
The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) remains a public health concern and a subject of active research effort. Development...
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Sex Differences in Age-Related Changes in Functional Activity and Expression of the Main Regulatory Proteins of the Renin–Angiotensin System in the Aorta and Myocardium of Rats
AbstractThe sex differences of age-related changes in the functional activity and expression of receptor and regulatory proteins of the...
