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Y-Chromosome Deletion Testing in Infertility
Y-chromosome harbours genes critical for gonadal development and the maintenance of spermatogenesis. Deletions in the AZF region of the Y-chromosome...
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DDX3Y is likely the key spermatogenic factor in the AZFa region that contributes to human non-obstructive azoospermia
Non-obstructive azoospermia, the absence of sperm in the ejaculate due to disturbed spermatogenesis, represents the most severe form of male...
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In vitro effects of uncarboxylated osteocalcin on buffalo Leydig cell steroidogenesis
Uncarboxylated osteocalcin (UcOCN), a bone derived circulating protein, has been demonstrated to influence steroidogenesis in testicular Leydig cells...
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Lipidomics random forest algorithm of seminal plasma is a promising method for enhancing the diagnosis of necrozoospermia
BackgroundDespite the clear clinical diagnostic criteria for necrozoospermia in andrology, the fundamental mechanisms underlying it remain elusive....
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Oxidative and Nitrosative Stress Detection in Human Sperm Using Fluorescent Probes
As a natural by-product of mitochondrial respiration, reactive oxygen species (ROS) in sperm play a role in promoting fertilization, by intervening...
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Serum and Seminal Plasma Levels of Lead and Arsenic in Cigarette Smokers and Their Relation to the Semen Parameters
Male infertility along with altered semen parameters have been related to smoking. Smoking-related elevations in serum and seminal lead (Pb) and...
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Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology
According to the free hormone hypothesis, biological activity of a certain hormone is best reflected by free rather than total hormone...
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Leptin Fragment 116–122 Modulates Testicular Steroidogenesis in Male Rats
AbstractThe adipokine leptin plays an important role in the regulation of the reproductive system. It stimulates the activity of the...
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Chromatin condensation but not DNA integrity of pig sperm is greater in the sperm-rich fraction
BackgroundProtamination and condensation of sperm chromatin as well as DNA integrity play an essential role during fertilization and embryo...
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Sperm DNA Fragmentation Testing in Infertility
Sperm DNA fragmentation (SDF) refers to breaks or damage in the DNA strand(s) in sperm cells, which can lead to an increased risk of male...
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Effect of bacterial infection on sperm quality and DNA fragmentation in subfertile men with Leukocytospermia
BackgroundAlthough bacterial infections have been recognized as a possible cause of male infertility, the effect of bacterial infections on sperm...
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Prevalence of Y chromosome microdeletion in north Indian infertile males with spermatogenesis defect
Deletion of specific genes present in the long arm of Y chromosome has been identified as the most common genetic cause of defective spermatogenesis....
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Sperm culture and bacterial susceptibility to antibiotics in a large andrological population: prevalence and impact on seminal parameters
BackgroundThe aim of this study was to evaluate (i) the prevalence of subjects with a positive sperm culture (SC) for bacteria in subjects with or...
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Immature rat testis sustained long-term development using an integrative model
BackgroundXenotransplantation has been primarily performed using fresh donor tissue to study testicular development for about 20 years, and whether...
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A pumpless monolayer microfluidic device based on mesenchymal stem cell-conditioned medium promotes neonatal mouse in vitro spermatogenesis
BackgroundChildhood cancer treatment-induced gonadotoxicity causes permanent infertility/sub-infertility in nearly half of males. The current...
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Estrogenic endocrine disruptor exposure directly impacts erectile function
Erectile dysfunction (ED) is an extremely prevalent condition which significantly impacts quality of life. The rapid increase of ED in recent decades...
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Fluorochromes for the Study of the Cell Features
This chapter is dedicated to fluorochromes used in the study of cellular characteristics. It divides them according to the characteristics studied,...
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Sperm epigenetics and sperm RNAs as drivers of male infertility: truth or myth?
Male infertility represents a complex clinical condition that often challenges the ability of reproductive specialists to find its etiology and then...
