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Androgen-responsive FOXP4 is a target for endometrial carcinoma
Although low estrogen is considered to suppress uterine endometrial carcinoma, the most cases occur in the postmenopausal stage. After menopause, the...
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Filamin A cooperates with the androgen receptor in preventing skeletal muscle senescence
Aging induces a slow and progressive decrease in muscle mass and function, causing sarcopenia. Androgens control muscle trophism and exert important...
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Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans
Development of the gonads under complex androgen regulation is critical for germ cells specification. In this work we addressed the relationship...
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Kaempferol suppresses androgen-dependent and androgen-independent prostate cancer by regulating Ki67 expression
PurposeKaempferol is a natural flavonoid that has been reported to be active against many cancers, including prostate cancer, breast cancer and colon...
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A carboxy-terminal ubiquitylation site regulates androgen receptor activity
Degradation of unliganded androgen receptor (AR) in prostate cancer cells can be prevented by proteasome inhibition, but this is associated with only...
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Photoperiod Regulates the Expression of GPx-5 in the Epididymis of Cricetulus barabensis through Androgen
AbstractFor animals that breed seasonally, photoperiod is a key factor in controlling their behavior. Epididymal function is highly dependent on...
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Androgen deprivation restores ARHGEF2 to promote neuroendocrine differentiation of prostate cancer
Androgen receptor (AR) plays an important role in the progression of prostate cancer and has been targeted by castration or AR-antagonists. The...
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Aberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse
The prostate is a vital accessory gonad in the mammalian male reproductive system. With the ever-increasing proportion of the population over 60...
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Four novel mutations in the androgen receptor gene from Vietnamese patients with androgen insensitivity syndrome
BackgroundAndrogens and androgen receptor (AR) are critical regulators of the masculinization process in male sexual development. The absence of a...
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Elevated luteinizing hormone receptor signaling or selenium treatment leads to comparable changes in adrenal cortex histology and androgen-AR/ZIP9 signaling
The importance and regulation of adrenal androgen production and signaling are not completely understood and are scarcely studied. In addition, there...
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Androgen dihydrotestosterone promotes bladder cancer cell proliferation and invasion via EPPK1-mediated MAPK/JUP signalling
The incidence of bladder cancer (BLCA) in men is higher than that in women. Differences in androgen levels between men and women are considered the...
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Enzalutamide induces cytotoxicity in desmoplastic small round cell tumor independent of the androgen receptor
Desmoplastic Small Round Cell Tumor (DSRCT) is a rare, pediatric cancer caused by the EWSR1::WT1 fusion protein. DSRCT predominantly occurs in males,...
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Canonical and truncated transglutaminase-2 regulate mucin-1 expression and androgen independency in prostate cancer cell lines
Androgen independency is associated with poor prostate cancer (PCa) survival. Here we report that silencing of transglutaminase-2 (TG2) expression by...
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Selenium Nanoparticles Modulate Steroidogenesis-Related Genes and Improve Ovarian Functions via Regulating Androgen Receptors Expression in Polycystic Ovary Syndrome Rat Model
Polycystic ovary syndrome (PCOS) occurs during the reproductive period in women and is characterized by reproductive, endocrine, and metabolic...
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Androgen deprivation induces neuroendocrine phenotypes in prostate cancer cells through CREB1/EZH2-mediated downregulation of REST
Although effective initially, prolonged androgen deprivation therapy (ADT) promotes neuroendocrine differentiation (NED) and prostate cancer (PCa)...
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Two somatic mutations in the androgen receptor N-terminal domain are oncogenic drivers in hepatocellular carcinoma
The androgen receptor ( AR ) plays an important role in male-dominant hepatocellular carcinoma, and specific acquired somatic mutations of AR have been...
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Second generation androgen receptor antagonists and challenges in prostate cancer treatment
Prostate cancer is a hormone-dependent malignancy, whose onset and progression are closely related to the activity of the androgen receptor (AR)...
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Lncap-AI prostate cancer cell line establishment by Flutamide and androgen-free environment to promote cell adherent
BackgroundTo establish castration-resistant prostate cancer (CRPC) - Lncap androgen-independent (AI) cell line from Lncap androgen-dependent (AD)...
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The androgen receptor interacts with GATA3 to transcriptionally regulate a luminal epithelial cell phenotype in breast cancer
BackgroundThe androgen receptor (AR) is a tumor suppressor in estrogen receptor (ER) positive breast cancer, a role sustained in some ER negative...
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Differential expression of the androgen receptor gene is correlated with CAG polymorphic repeats in patients with prostate cancer
Prostate cancer (PCa) is one of the most common types of cancer in men. The aetiology of the disease is not well established, but it has been related...
