Search
Search Results
-
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)
Substrate polyubiquitination drives a myriad of cellular processes, including the cell cycle, apoptosis and immune responses. Polyubiquitination is...
-
Mechanisms for the temporal regulation of substrate ubiquitination by the anaphase-promoting complex/cyclosome
The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit, multifunctional ubiquitin ligase that controls the temporal degradation of...
-
piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis
Piwi proteins are normally restricted in germ cells to suppress transposons through associations with Piwi-interacting RNAs (piRNAs), but they are...
-
Principles and dynamics of spindle assembly checkpoint signalling
The transmission of a complete set of chromosomes to daughter cells during cell division is vital for development and tissue homeostasis. The spindle...
-
The ubiquitin-proteasome pathway in cell cycle control
Ubiquitin-mediated proteolysis is one of the key mechanisms underlying cell cycle control. The removal of barriers posed by accumulation of...
-
Role of chromosomal cohesion and separation in aneuploidy and tumorigenesis
Cell division is a crucial process, and one of its essential steps involves copying the genetic material, which is organized into structures called...
-
Real-Time Monitoring of APC /C-Mediated Substrate Degradation Using Xenopus laevis Egg Extracts
The anaphase promoting complex/cyclosome (APC/CAPC/C), a large E3 ubiquitin ligase, is a key regulator of mitotic progression. Upon activation in...
-
Aneuploidy and complex genomic rearrangements in cancer evolution
Mutational processes that alter large genomic regions occur frequently in develo** tumors. They range from simple copy number gains and losses to...
-
Full and D-BOX-Deficient PTTG1 Isoforms: Effects on Cell Proliferation
AbstractHuman securin (PTTG1) is a protooncogene whose expression is elevated in many types of malignant cells. We previously discovered a minor...
-
The Anaphase Promoting Complex/Cyclosome (APC/C): A Versatile E3 Ubiquitin Ligase
In the present chapter we discuss the essential roles of the human E3 ubiquitin ligaseE3 ubiquitin ligase Anaphase Promoting ComplexAnaphase...
-
The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis
Faithful chromosome segregation requires bi-oriented kinetochore-microtubule attachment on the metaphase spindle. Aurora B kinase, the catalytic core...
-
Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth
Tumors can reprogram the functions of metabolic enzymes to fuel malignant growth; however, beyond their conventional functions, key metabolic enzymes...
-
The SUMO–NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure
SUMOylation regulates numerous cellular processes, but what represents the essential functions of this protein modification remains unclear. To...
-
Author Correction: piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
MAPK-dependent control of mitotic progression in S. pombe
BackgroundMitogen-activated protein kinases (MAPKs) preserve cell homeostasis by transducing physicochemical fluctuations of the environment into...
-
The Transcriptional MEDIATOR Complex: Linking Root Development, Hormonal Responses, and Nutrient Stress
The MEDIATOR complex is a large multiprotein assembly ubiquitous to eukaryotic organisms that acts as a transcriptional coactivator. Although its...
-
FBXO5-mediated RNF183 degradation prevents endoplasmic reticulum stress-induced apoptosis and promotes colon cancer progression
Endoplasmic reticulum (ER) stress induces the unfolded protein response (UPR), and prolonged ER stress leads to cell apoptosis. Despite increasing...
-
Multiple intermolecular interactions facilitate rapid evolution of essential genes
Essential genes are commonly assumed to function in basic cellular processes and to change slowly. However, it remains unclear whether all essential...
-
Multiple functions of SWI/SNF chromatin remodeling complex in plant-pathogen interactions
The SWI/SNF chromatin remodeling complex utilizes the energy of ATP hydrolysis to facilitate chromatin access and plays essential roles in DNA-based...
-
APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition
BackgroundIn addition to functioning as a precise monitoring mechanism in cell cycle, the anaphase-promoting complex/cyclosome (APC/C) is reported to...
