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Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol
Amyloid β is considered a key player in the development and progression of Alzheimer’s disease (AD). Many studies investigating the effect of statins...
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Assessment of Amyloid Morphology Using Electron Microscopy
Aβ amyloid fibrils have been demonstrated to be vital for triggering Alzheimer’s disease, as reported by numerous research works. Therefore, Aβ...
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Structure and Polymorphism of Amyloid and Amyloid-Like Aggregates
AbstractAmyloids are protein aggregates with the cross-β structure. The interest in amyloids is explained, on the one hand, by their role in the...
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Screening Carbon Nano Materials for Preventing Amyloid Protein Aggregation by Adopting a Facile Method
The soluble-to-toxic transformation of intrinsically disordered amyloidogenic proteins such as amyloid beta (Aβ), α-synuclein, mutant Huntingtin...
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The worldwide need for amyloid diagnosis in animals
Deposition of amyloid in tissues and organs leads to amyloidosis, impacting the function of vital organs and often resulting in mortality. About 42...
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Unveiling the mechanistic link between extracellular amyloid fibrils, mechano-signaling and YAP activation in cancer
The tumor microenvironment is a complex ecosystem that plays a critical role in cancer progression and treatment response. Recently, extracellular...
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Modelling of Anti-amyloid-Beta Therapy for Alzheimer’s Disease
A healthy brain clears different types of debris with the help of specialized glial cells. These cells contiguously tile the entire central nervous...
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Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils
Many proteins self-assemble to form amyloid fibrils, which are highly organized structures stabilized by a characteristic cross-β network of hydrogen...
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Release of frustration drives corneal amyloid disaggregation by brain chaperone
TGFBI-related corneal dystrophy (CD) is characterized by the accumulation of insoluble protein deposits in the corneal tissues, eventually leading to...
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Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence
Dysfunctional autophagy has been implicated in the pathogenesis of Alzheimer’s disease (AD). Previous evidence suggested disruptions of multiple...
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Zinc and pH modulate the ability of insulin to inhibit aggregation of islet amyloid polypeptide
Aggregation of the human islet amyloid polypeptide (hIAPP) contributes to the development and progression of Type 2 Diabetes (T2D). hIAPP aggregates...
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Amyloid peptides with antimicrobial and/or microbial agglutination activity
AbstractMicrobe (including bacteria, fungi, and virus) infection in brains is associated with amyloid fibril deposit and neurodegeneration....
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Pre-clinical evaluation of 99mTc-labeled chalcone derivative for amyloid-β imaging post-head trauma
Aβ 42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most...
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Membrane-induced tau amyloid fibrils
The intrinsically disordered protein tau aggregates into β-sheet amyloid fibrils that spread in human brains afflicted with Alzheimer’s disease and...
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Structural Polymorphism of Lysozyme Amyloid Fibrils
AbstractAccording to the modern concepts, polymorphism of amyloid fibrils can be the cause of the differences in its cytotoxicity and the variability...
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Effect of dynamic exclusion and the use of FAIMS, DIA and MALDI-mass spectrometry imaging with ion mobility on amyloid protein identification
Amyloidosis is a disease characterized by local and systemic extracellular deposition of amyloid protein fibrils where its excessive accumulation in...
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ENTAIL: yEt aNoTher amyloid fIbrils cLassifier
BackgroundThis research aims to increase our knowledge of amyloidoses. These disorders cause incorrect protein folding, affecting protein...
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Electrochemical Analysis in Studying β-Amyloid Aggregation
Abstractβ-amyloid (Aβ) is comprised of a group of peptides formed as a result of cleavage of the amyloid precursor protein by secretases. Aβ...
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Rab11A Depletion in Microglia-Derived Extracellular Vesicle Proteome upon Beta-Amyloid Treatment
Microglia, the macrophage-like glial cells, behave as sentinels against exogenous pathogens invading the neural tissue. Their commitment is not only...
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Cryo-EM structures of amyloid-β and tau filaments in Down syndrome
Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there is a difference between AD in DS and AD regarding the...
