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Nontargeted Identification of d-Amino Acid-Containing Peptides Through Enzymatic Screening, Chiral Amino Acid Analysis, and LC-MS
d-amino acid-containing peptides (DAACPs) in animals are a class of bioactive molecules formed via the posttranslational modification of peptides...
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Fatty Acid Amino Acid Conjugates (FACs)
In caterpillar oral secretions, fatty acid amino acid conjugates (FACs) elicit plant defense responses during herbivory. The levels of these FAC...
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Clustered surface amino acid residues modulate the acid stability of GH10 xylanase in fungi
AbstractAcidic xylanases are widely used in industries such as biofuels, animal feeding, and fruit juice clarification due to their tolerance to...
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Amino acid metabolism in tumor biology and therapy
Amino acid metabolism plays important roles in tumor biology and tumor therapy. Accumulating evidence has shown that amino acids contribute to...
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Broad Spectrum Amino Acid Racemases (Bsrs): A Potential Target in Microbial Research
Broad spectrum amino acid racemases (Bsrs) aid bacteria in producing non-canonical D-amino acids (NCDAA), which play significant functions in the...
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Amino-Acid Composition of Proteins in Hulled and Naked Oats
AbstractThe purpose of this study was to evaluate the balance of essential amino acids in proteins of hulled and naked oat varieties relative to the...
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Biosynthesis of macrolactam antibiotics with β-amino acid polyketide starter units
Macrolactam antibiotics incorporating β-amino acid polyketide starter units, isolated primarily from Actinomycetes species, show significant...
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Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth
Amino acid homeostasis is critical for many cellular processes. It is well established that amino acids are compartmentalized using pH gradients...
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Amino Acid Content in the Spring Common Wheat Grains
AbstractThe study was aimed to determine the differences in amino acid content in wheat grains from the collection of Vavilov All-Russia Institute of...
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Serum amino acid profiles in patients with myasthenia gravis
Myasthenia gravis (MG) is an autoimmune disease characterized by weakness and rapid fatigue. Diagnostic methods used for myasthenia gravis are not...
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Mechanism of D-Cycloserine Inhibition of D-Amino Acid Transaminase from Haliscomenobacter hydrossis
AbstractD-cycloserine inhibits pyridoxal-5′-phosphate (PLP)-dependent enzymes. Inhibition effect depend on organization of the active site and...
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Amino acid profiles, amino acid sensors and transporters expression and intestinal microbiota are differentially altered in goats infected with Haemonchus contortus
Infection with the nematode Haemonchus contortus causes host malnutrition and gastrointestinal injuries. The objective of this study was to...
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Epivolve: A Protocol for Site-Directed Antibodies
Researchers can often successfully generate antibodies to predicted epitopes. Especially when the epitopes are on the surface of a protein or in a...
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Essential amino acid residues and catalytic mechanism of trans-epoxysuccinate hydrolase for production of meso-tartaric acid
ObjectivesThis study aimed to discuss the essential amino acid residues and catalytic mechanism of trans -epoxysuccinate hydrolase from Pseudomonas...
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Deconvolving feeding niches and strategies of abyssal holothurians from their stable isotope, amino acid, and fatty acid composition
Holothurians are the dominant megabenthic deposit feeders in the Peru Basin (SE Pacific) and feed to various degrees of selectivity on a heterogenous...
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Amino acid insertion in Bat MHC-I enhances complex stability and augments peptide presentation
Bats serve as reservoirs for numerous zoonotic viruses, yet they typically remain asymptomatic owing to their unique immune system. Of particular...
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Amino acid metabolism regulated by lncRNAs: the propellant behind cancer metabolic reprogramming
Metabolic reprogramming is one of the main characteristics of cancer cells and plays pivotal role in the proliferation and survival of cancer cells....
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Development of orthogonal aminoacyl-tRNA synthetase mutant for incorporating a non-canonical amino acid
Genetic code expansion involves introducing non-canonical amino acids (ncAAs) with unique functional groups into proteins to broaden their...
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Impact of Amino Acid Foliar Applications on Soybean under Optimal and Water-Deficit Conditions: Photosynthesis, Antioxidants, Osmotic Adjustment, and Fatty Acids
AbstractAmino acids aid plant stress tolerance, but their precise role in soybean drought physiology remains unclear. This study included amino acid...
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Novel recombinant aminoacylase from Paraburkholderia monticola capable of N-acyl-amino acid synthesis
AbstractN-Acyl-amino acids can act as mild biobased surfactants, which are used, e.g., in baby shampoos. However, their chemical synthesis needs acyl...
