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Prevalence of different virulence factors and their association with antimicrobial resistance among Pseudomonas aeruginosa clinical isolates from Egypt
BackgroundEmergence of multi-drug resistant Pseudomonas aeruginosa, coupled with the pathogen’s versatile virulence factors, lead to high morbidity...
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Pharmacoinformatics-based identification of transmembrane protease serine-2 inhibitors from Morus Alba as SARS-CoV-2 cell entry inhibitors
AbstractTransmembrane protease serine-2 (TMPRSS2) is a cell-surface protein expressed by epithelial cells of specific tissues including those in the...
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Identification of genes related to ribosomal proteins in colorectal cancer: exploring their potential as biomarkers, prognostic indicators, and therapeutic targets
BackgroundColorectal cancer (CRC) ranks as the third most commonly diagnosed cancer in both females and males, underscoring the need for the...
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Enhancing access to treatment for Gaucher disease in India: The need for indigenous manufacturing
Gaucher disease (GD) is a prevalent lysosomal storage disorder (LSD) that significantly impacts individuals’ lives. However, the exorbitant prices of...
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Targeting the intestinal TMPRSS2 protease to prevent SARS-CoV-2 entry into enterocytes-prospects and challenges
The transmembrane protease serine 2 (TMPRSS2) is a membrane anchored protease that primarily expressed by epithelial cells of respiratory and...
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An improved Glucocerebrosidase Assay for Accurate Prediction of Lysosomal Dysfunction: Exemplified by Its Relevance in Parkinson’s Disease
Functional lysosomes are crucial for preventing the abnormal accumulation of proteins and resulting neuronal injury and cell death associated with...
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Human Peripheral Blood Macrophages As a Model for Studying Glucocerebrosidase Dysfunction
Abstract—Decreased activity of glucocerebrosidase (GCase) as a result of mutations in the GBA gene causes Gaucher’s disease (GD), which belongs to...
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Chemistry, Biological Activities, and Uses of Tara Gum
Galactomannans are high molecular weight plant polysaccharides obtained from legume seeds of annual crops or perennial trees and shrubs. These...
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Chemistry, Biological Activities, and Uses of Tara Gum
Galactomannans are high molecular weight plant polysaccharides obtained from legume seeds of annual crops or perennial trees and shrubs. These...
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Integrating Multimorbidity into a Whole-Body Understanding of Disease Using Spatial Genomics
Multimorbidity is characterized by multidimensional complexity emerging from interactions between multiple diseases across levels of biological...
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Antimicrobial efficiency of bromhexine hydrochloride against endometritis-causing Escherichia coli and Trueperella pyogenes in bovines
In this study, the main agents associated with endometritis in cows in the state of Santa Catarina, Brazil, were identified and the resistance...
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Respiratory RNA Viruses: How to Be Prepared for an Encounter with New Pandemic Virus Strains
AbstractThe characteristics of the biology of influenza viruses and coronavirus that determine the implementation of the infectious process are...
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Mercury Levels in Selected Medicines and Dietary Supplements in Poland
Current trends are promoting youth, beauty, health, and fitness. Individuals often seek out remedies, such as medicines or dietary supplements (DS),...
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In vitro antibacterial effects of combination of ciprofloxacin with compounds isolated from Streptomyces luteireticuli NIIST-D75
Three phenazines, 1-methoxyphenazine ( 1 ), methyl-6-methoxyphenazine-1-carboxylate ( 2 ), 1,6-dimethoxyphenazine ( 4 ), and a 2,3-dimethoxy benzamide ( 3 )...
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Sphingolipid lysosomal storage diseases: from bench to bedside
Johann Ludwig Wilhelm Thudicum described sphingolipids (SLs) in the late nineteenth century, but it was only in the past fifty years that SL research...
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Vascular nitric oxide resistance in type 2 diabetes
Vascular nitric oxide (NO•) resistance, manifested by an impaired vasodilator function of NO• in both the macro- and microvessels, is a common state...
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Hyaluronic Acid Coating on Hydrophobic Tracheal Scaffold Enhances Mesenchymal Stem Cell Adhesion and Tracheal Regeneration
BACKGROUND:Long segmental tracheal repair is challenging in regenerative medicine due to low adhesion of stem cells to tracheal scaffolds. Optimal...
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Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer
The deregulated genes in colorectal cancer (CRC) vary significantly across different studies. Thus, a systems biology approach is needed to identify...
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Advancements in understanding bacterial enteritis pathogenesis through organoids
Bacterial enteritis has a substantial role in contributing to a large portion of the global disease burden and serves as a major cause of newborn...
