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Fungal vaccines and adjuvants: a tool to reveal the interaction between host and fungi
Fungal infections are incurring high risks in a range from superficial mucosal discomforts (such as oropharyngeal candidiasis and vulvovaginal...
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STING agonists as promising vaccine adjuvants to boost immunogenicity against SARS-related coronavirus derived infection: possible role of autophagy
As a major component of innate immunity and a positive regulator of interferons, the Stimulator of interferon gene (STING) has an immunotherapy...
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Biogenic Selenium Nanoparticles Synthesized by L. brevis 23017 Enhance Aluminum Adjuvanticity and Make Up for its Disadvantage in Mice
The most popular vaccine adjuvants are aluminum ones, which have significantly reduced the incidence and mortality of many diseases. However,...
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Liposomes as Adjuvants and Vaccine Delivery Systems
AbstractThe review considers liposomes as systems of substantial interest as adjuvant carriers in vaccinology due to their versatility and maximal...
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Formulation of IMXQB: Nanoparticles Based on Quillaja brasiliensis Saponins to be Used as Vaccine Adjuvants
Adjuvants are essential components of subunit, recombinant, nonreplicating and killed vaccines, as they are substances that boost, shape, and/or...
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Rutin, Puerarin and Silymarin Regulated Aluminum-Induced Imbalance of Neurotransmitters and Metal Elements in Brain of Rats
Non-specifically binding of aluminum to various substances in the organism can result in toxicity. The accumulation of large amounts of aluminum can...
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Innovative Vaccine Strategy: Self-Adjuvanting Conjugate Vaccines
Self-adjuvanting vaccines, covalent conjugates between antigens and adjuvants, are chemically well-defined compared with conventional vaccines...
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Bioeconomy for Sustainable Biomaterials and Bioproduct Development
The economy and health sector are robustly shattered by emerging infectious diseases across the globe. The modern-generation vaccines including viral...
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Vaccine Development for Severe Fever with Thrombocytopenia Syndrome Virus in Dogs
Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening viral zoonosis. The causative agent of this disease is the Dabie bandavirus ,...
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Chemical Synthesis and Immunomodulatory Functions of Bacterial Lipid As
Lipopolysaccharide (LPS), a cell surface component of Gram-negative bacteria, and its active principle, lipid A, have immunostimulatory properties...
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Peptide ILE-GLU-TRP (Stemokin) Potential Adjuvant Stimulating a Balanced Immune Response
Vaccines are widely used worldwide to prevent and protect from various infections. A variety of modern approaches to develo** prophylactic and...
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A COVID-19 vaccine candidate based on SARS-CoV-2 spike protein and immune-stimulating complexes
AbstractSpike protein from SARS-CoV-2, the etiologic agent of the COVID-19 pandemic disease, constitutes a structural protein that proved to be the...
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Fish oral vaccine and mucosal immunity
Fish can be vaccinated by injection, intramuscularly (IM) or intraperitoneally (IP), and orally. Using oral immunization provides the most attractive...
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Aluminum doped carbon nanodots as potent adjuvants on the mammalian macrophages
AbstractIn this manuscript, we aimed to report the synthesis of aluminum (Al) incorporated carbon nanodots (CD) and their activities on the immune...
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A combined inactivated cholera and hepatitis A vaccine-induced potent protective immunity in a mouse model
AbstractCholera and hepatitis A are serious infections spread by consuming contaminated food or water. Vaccination is the most effective strategy to...
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Efficacy of combined inactivated vaccines against Vibrio alginolyticus and Streptococcus agalactiae infections in Nile tilapia in Egypt
Vibrio alginolyticus and Streptococcus agalactiae are important bacterial pathogens that yielded high losses in Nile tilapia in Egypt. The present...
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Synthetic selenium nanoparticles as co-adjuvant improved immune responses against methicillin-resistant Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the leading causes of hospital-acquired infections worldwide, which is resistant to many...
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Current Trends in the Development of Vaccines from Micro to Industrial Level
Vaccines have been widely used for controlling infectious diseases. They are one of the cost-effective strategies that could be substantially...
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Self-adjuvant Astragalus polysaccharide-based nanovaccines for enhanced tumor immunotherapy: a novel delivery system candidate for tumor vaccines
The study of tumor nanovaccines (NVs) has gained interest because they specifically recognize and eliminate tumor cells. However, the poor...
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Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for Escherichia coli-based vaccine design
Varicella-zoster virus (VZV) is a highly infectious agent responsible for both varicella and herpes zoster disease. Despite high efficacy, there...