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Allergen-induced CD11c + dendritic cell pyroptosis aggravates allergic rhinitis
BackgroundPyroptosis is crucial for controlling various immune cells. However, the role of allergen-induced CD11c + dendritic cell (DC) pyroptosis in...
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Three Artemisia pollens trigger the onset of allergic rhinitis via TLR4/MyD88 signaling pathway
ObjectiveThe prevalence of allergic rhinitis is high, making it a relatively common chronic condition. Countless patients suffer from seasonal...
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Identification and analysis of lipid metabolism-related genes in allergic rhinitis
BackgroundStudies have shown that the lipid metabolism mediator leukotriene and prostaglandins are associated with the pathogenesis of allergic...
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Dendritic cells mediated by small extracellular vesicles derived from MSCs attenuated the ILC2 activity via PGE2 in patients with allergic rhinitis
BackgroundMesenchymal stromal cells-derived small extracellular vesicles (MSC-sEVs) have recently attracted considerable attention because of their...
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Exacerbation of allergic rhinitis by the commensal bacterium Streptococcus salivarius
Allergic rhinitis (AR)—commonly called hay fever—is a widespread condition that affects the quality of life of millions of people. The...
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Downregulation of lncRNA CDKN2B-AS1 attenuates inflammatory response in mice with allergic rhinitis by regulating miR-98-5p/SOCS1 axis
Long non-coding RNA cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) in various diseases has been verified. However, the underlying...
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Decoding the role of DNA methylation in allergic diseases: from pathogenesis to therapy
Allergic diseases, characterized by a broad spectrum of clinical manifestations and symptoms, encompass a significant category of IgE-mediated atopic...
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Identification of Some Promising Heterocycles Useful in Treatment of Allergic Rhinitis: Virtual Screening, Pharmacophore Map**, Molecular Docking, and Molecular Dynamics
AbstractRhinitis is an allergic disease that causes troubles and restlessness for patients. In this research work we will focus on finding promising...
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Assessment of the nasal microbiota in dogs with fungal rhinitis before and after cure and in dogs with chronic idiopathic rhinitis
BackgroundPathogenesis of canine fungal rhinitis is still not fully understood. Treatment remains challenging, after cure turbinate destruction may...
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Intranasal PAMAM-G3 scavenges cell-free DNA attenuating the allergic airway inflammation
Allergic airway inflammation (AAI), including allergic rhinitis (AR) and allergic asthma, is driven by epithelial barrier dysfunction and type 2...
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Identification of plasma protein markers of allergic disease risk: a mendelian randomization approach to proteomic analysis
BackgroundWhile numerous allergy-related biomarkers and targeted treatment strategies have been developed and employed, there are still signifcant...
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Mesenchymal stem cells overexpressing interleukin-10 prevent allergic airway inflammation
BackgroundsAllergic airway inflammation is prevalent worldwide and imposes a considerable burden on both society and affected individuals. This study...
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Role of Probiotics in Allergic Diseases
The prevalence of allergic disorders has been increasing worldwide and significantly impacts the quality of life of the atopic individual. There has...
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MiR-150-5p regulates the functions of type 2 innate lymphoid cells via the ICAM-1/p38 MAPK axis in allergic rhinitis
Type 2 innate lymphoid cells (ILC2s) exert an increasingly important influence on the pathological process of allergic rhinitis (AR), which is...
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Elevated level of multibranched complex glycan reveals an allergic tolerance status
BackgroundAllergen immunotherapy (AIT) is the only disease-modifying therapy that can achieve immune tolerance in patients through long-term allergen...
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Circ_0067835 regulates allergic inflammatory response in type-2 innate lymphoid cells in allergic rhinitis (AR) via miR-155/GATA3
Allergic rhinitis (AR) is a familiar respiratory allergic inflammatory disease with higher incidence. The pathogenesis of AR is particularly complex....
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Sensitization to Airborne Fungal Allergens Associates with Asthma and Allergic Rhinitis Presentation and Severity in the Singaporean/Malaysian Population
Fungal spores and conidia are the major components of total airspora in the tropical Asia environment, and their sensitization patterns are often...
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Symbiotic microbiome Staphylococcus epidermidis restricts IL-33 production in allergic nasal epithelium via limiting the cellular necroptosis
BackgroundAllergic rhinitis (AR) is characterized by airway inflammation in nasal mucosa from inhaled allergens and interleukin (IL)-33 is the potent...
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Mechanisms of Formation and Persistence of IgE Products and Potential Innovative Means of Therapy for Allergic Pathologies
This review is devoted to the analysis of the main mechanisms of the formation of IgE-producing cells in the body and a brief review of the main,...
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Allergic asthma is a risk factor for human cardiovascular diseases
Asthma is an allergic airway disease in which type 2-mediated inflammation has a pathogenic role. Cardiovascular diseases (CVDs) are type 1-dominant...
