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Recent Strategies to Engineer Alkaloid Biosynthesis in Medicinal Plants
Plants are known to synthesize a plethora of secondary metabolites viz., terpenoids, terpenes, flavonoids and alkaloids. Of these, alkaloids belong...
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Emerging functions within the enzyme families of plant alkaloid biosynthesis
The alkaloids are a major class of nitrogen-containing plant specialized metabolites that function as both toxic defense compounds and useful...
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RNA-seq Analysis of Monoterpene Indole Alkaloid Biosynthetic Pathway Elucidation in Catharanthus roseus
Increased affordability and availability of high-throughput next-generation sequencing (NGS) technologies have resulted in an explosion of available...
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Integrated metabolomic and transcriptomic analysis reveals the regulatory mechanisms of flavonoid and alkaloid biosynthesis in the new and old leaves of Murraya tetramera Huang
BackgroundMurraya tetramera Huang is a traditional Chinese woody medicine. Its leaves contain flavonoids, alkaloids, and other active compounds,...
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Functional Genomics Approaches for Gene Discovery Related to Terpenoid Indole Alkaloid Biosynthetic Pathway in Catharanthus roseus
Catharanthus roseus is one of the most explored medicinal plants owing to its immense potential to synthesize various terpenoid indole alkaloids...
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Plant cytochrome P450s directing monoterpene indole alkaloid (MIA) and benzylisoquinoline alkaloid (BIA) biosynthesis
The large family of cytochrome P450 enzymes are heme containing proteins generally associated with the cytoplasmic face of the endoplasmic reticulum...
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Combining Metabolomics and Metagenomics to Analyze the Biosynthetic Potential of Culturable Endophytic Fungi Isolated from Salvia miltiorrhiza
AbstractPlant endophytic fungi are reservoirs of novel bioactive natural products, which may be used directly or indirectly to treat numerous...
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Combined analysis of the metabolome and transcriptome reveals the metabolic characteristics and candidate genes involved in alkaloid metabolism in Heuchera micrantha Douglas ex Lindl
BackgroundAlkaloids, important secondary metabolites produced by plants, play a crucial role in responding to environmental stress. Heuchera micrantha ...
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Comparative bioinformatics analysis of the biosynthetic pathways and key candidate genes of three species, Vitis vinifera, Fragaria vesca and Olea europaea, furnish enzyme sets for the production of pharmaceutically valuable terpenes in heterologous hosts
Plants represent a rich repository of taxonomically restricted, yet chemically diverse, secondary metabolites that are synthesised via specific...
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Alkaloid Synthesis in In Vitro Cultures of Catharanthus Roseus: Potential and Limitations
Catharanthus roseus (L.) G. Don, Madagascar periwinkle, was among the first plants to be explored for the in vitro production of fine chemicals, due...
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Modulation of terpenoid indole alkaloid pathway via elicitation with phytosynthesized silver nanoparticles for the enhancement of ajmalicine, a pharmaceutically important alkaloid
Main conclusionThe use of silver nanoparticles as elicitors in cell cultures of Rauwolfia serpentina resulted in increased levels of ajmalicine,...
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Alkaloid chemistry in pill-millipedes: Defensive secretion in two species of Typhloglomeris Verhoeff, 1898 (Diplopoda, Glomerida, Glomeridellidae)
Millipedes of the order Glomerida are known to produce quinazolinone alkaloids as defensive substances. However, chemical data are rather scarce and...
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Gene clustering and co-expression analysis for the identification of putative transcription factors associated with the genes of secondary metabolic pathways in Plantago ovata Forsk. and its wild allies
Genus Plantago of Plantaginaceae family is bestowed with a repertoire of structurally diverse secondary metabolites that have not only been used as...
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Amino acid (acyl carrier protein) ligase-associated biosynthetic gene clusters reveal unexplored biosynthetic potential
This study aimed to evaluate the postulated cellular function of a novel family of amino acid (acyl carrier protein) ligases (AALs) in natural...
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Alteration in the callogenesis, tropane alkaloid formation, and gene expression in Hyoscyamus niger under clinorotation
This study aimed to investigate the effects of clinorotation induced by 2-D clinostat on the growth, tropane alkaloid production, gene expression,...
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A Multi-Label Learning Framework for Predicting Chemical Classes and Biological Activities of Natural Products from Biosynthetic Gene Clusters
Natural products (NP) or secondary metabolites, as a class of small chemical molecules that are naturally synthesized by chromosomally clustered...
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Biogeographic patterns of biosynthetic potential and specialized metabolites in marine sediments
While the field of microbial biogeography has largely focused on the contributions of abiotic factors to community patterns, the potential influence...
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Alkaloid diversification in the genus Palicourea (Rubiaceae: Palicoureeae) viewed from a (retro-)biogenetic perspective
The species-rich genus Palicourea (Rubiaceae: Palicoureeae) is source of an intriguing diversity of alkaloids derived from tryptamine and its...
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Omics analyses of Rehmannia glutinosa dedifferentiated and cambial meristematic cells reveal mechanisms of catalpol and indole alkaloid biosynthesis
BackgroundRehmannia glutinosa is a rich source of terpenoids with a high medicinal reputation. The present study compared dedifferentiated cells...
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Mining and functional characterization of NADPH-cytochrome P450 reductases of the DNJ biosynthetic pathway in mulberry leaves
Background1-Deoxynojirimycin (DNJ), the main active ingredient in mulberry leaves, with wide applications in the medicine and food industries due to...
