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Isolation and Purification of Natural Products from Microbial Cultures
Antibiotic natural products from microbes are characterized by diverse and mostly complex chemical structures, which challenge their total chemical...
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Culture of Actinobacteria, Isolation and Characterization of their Bioactive Compounds
Actinobacteria are prolific producers of secondary metabolites with a wide array of structural diversity and potent activities. These bioactive...
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Detection of the phycotoxin pectenotoxin-2 in waters around King George Island, Antarctica
In order to set a base line for the observation of planktonic community changes due to global change, protistan plankton sampling in combination with...
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Antibiotic resistance crisis: challenges and imperatives
Antibiotic resistance is one of the greatest worldwide challenges to modern medicine, and society at large, and one of the least appreciated by...
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Localized production of defence chemicals by intracellular symbionts of Haliclona sponges
Marine sponges often house small-molecule-producing symbionts extracellularly in their mesohyl, providing the host with a means of chemical defence...
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Enhanced production of camptothecin and biological preparation of N 1-acetylkynuramine in Camptotheca acuminata cell suspension cultures
The Camptotheca acuminata cell suspension cultures were established to produce the well-known antitumor monoterpene indole alkaloid camptothecin...
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Enhancement of ascomycin production in Streptomyces hygroscopicus var. ascomyceticus by combining resin HP20 addition and metabolic profiling analysis
Combinatorial approach of adsorbent resin HP20 addition and metabolic profiling analysis were carried out to enhance ascomycin production. Under the...
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Isolation and characterization of Paenibacillus polymyxa LY214, a camptothecin-producing endophytic bacterium from Camptotheca acuminata
Camptothecin (CPT) is mainly produced and extracted from Camptotheca acuminata and Nothapodytes foetida for pharmaceutical use, i.e., the starting...
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Camptothecin-producing endophytic fungus Trichoderma atroviride LY357: isolation, identification, and fermentation conditions optimization for camptothecin production
Camptothecin (CPT), the third largest anticancer drug, is produced mainly by Camptotheca acuminata and Nothapodytes foetida . CPT itself is the...
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Use of in situ solid-phase adsorption in microbial natural product fermentation development
It has been half a century since investigators first began experimenting with adding ion exchange resins during the fermentation of microbial natural...
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Fermentation, Isolation, Structure, and antidiabetic activity of NFAT-133 produced by Streptomyces strain PM0324667
Type-2 diabetes is mediated by defects in either insulin secretion or insulin action. In an effort to identify extracts that may stimulate glucose...
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Peculiarities of Pycnoporus species for applications in biotechnology
The genus Pycnoporus forms a cosmopolitan group of four species belonging to the polyporoid white-rot fungi, the most representative group of...
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Antifouling Activity of Marine Natural Products
With the global ban of application of organotin-based marine coatings by International Maritime Organization in 2008, there is a practical and urgent...
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Pilot-plant cultivation of Streptomyces griseus producing homologues of nonactin by precursor-directed biosynthesis and their identification by LC/MS-ESI
Precursor-directed biogenetic approach was used to produce a range of nonactin homologues in a 50 l fermentor cultivation of strain Streptomyces...
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Fermentative production of self-toxic fungal secondary metabolites
Fungi are well known for their vast diversity of secondary metabolites that include many life-saving drugs and highly toxic mycotoxins. In general,...
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Enhanced vanillin production from ferulic acid using adsorbent resin
High vanillin productivity was achieved in the batch biotransformation of ferulic acid by Streptomyces sp. strain V-1. Due to the toxicity of...
