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Innovative multidimensional models in a high-throughput-format for different cell types of endocrine origin
The adrenal gland provides an important function by integrating neuronal, immune, vascular, metabolic and endocrine signals under a common organ...
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ITRAQ-based proteomic analysis reveals possible target-related proteins in human adrenocortical adenomas
BackgroundAdrenocortical adenomas (ACAs) can lead to the autonomous secretion of aldosterone responsible for primary aldosteronism (PA), which is the...
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SIRT6 abrogation promotes adrenocortical carcinoma through activation of NF-κB signaling
As an uncommon malignancy in the adrenal gland, adrenocortical carcinoma (ACC) is characterized by thorny diagnosis and poor clinical outcome,...
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Case Study #5: CXCR4-Targeted Radiotherapeutics
Radiopharmaceutical therapy (RPT) has become a mainstay of modern oncology but remains limited to solid tumors, including orphan diseases such as...
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Neighborhood based computational approaches for the prediction of lncRNA-disease associations
MotivationLong non-coding RNAs (lncRNAs) are a class of molecules involved in important biological processes. Extensive efforts have been provided to...
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A novel MEN1 pathogenic variant in an Italian patient with multiple endocrine neoplasia type 1
The multiple endocrine neoplasia type 1 (MEN1) is a rare syndrome characterized by the predisposition to develo** multiple endocrine and...
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Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice
Canagliflozin (Cana), a clinically important anti-diabetes drug, leads to a 14% increase in median lifespan and a 9% increase in the 90th percentile...
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A recurrent somatic missense mutation in GNAS gene identified in familial thyroid follicular cell carcinomas in German longhaired pointer dogs
BackgroundWe previously reported a familial thyroid follicular cell carcinoma (FCC) in a large number of Dutch German longhaired pointers and...
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Associations of measured and genetically predicted leukocyte telomere length with vascular phenotypes: a population-based study
Shorter leukocyte telomere length (LTL) is associated with cardiovascular dysfunction. Whether this association differs between measured and...
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Molecular basis and current insights of atypical Rho small GTPase in cancer
Atypical Rho GTPases are a subtype of the Rho GTPase family that are involved in diverse cellular processes. The typical Rho GTPases, led by RhoA,...
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Kelch-like protein 3 in human disease and therapy
Kelch-like protein 3 (KLHL3) is a substrate adaptor of Cullin3-RING ubiquitin ligase (CRL3), and KLHL3-CUL3 complex plays a vital role in the...
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The (pro)renin receptor: a novel biomarker and potential therapeutic target for various cancers
BackgroundThe (pro) renin receptor ((P)RR) plays important roles in various pathways, such as the Wnt/β-catenin, renin-angiotensin system (RAS),...
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Melanocortin 2 receptor antagonists in canine pituitary-dependent hypercortisolism: in vitro studies
Canine hypercortisolism is most often caused by an ACTH-secreting pituitary adenoma (pituitary-dependent hypercortisolism; PDH). An interesting...
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Multi-omics analyses of MEN1 missense mutations identify disruption of menin–MLL and menin–JunD interactions as critical requirements for molecular pathogenicity
BackgroundLoss-of-function mutations of the multiple endocrine neoplasia type 1 ( MEN1 ) gene are causal to the MEN1 tumor syndrome, but they are also...
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Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target
Proline metabolism features prominently in the unique metabolism of cancer cells. Proline biosynthetic genes are consistently upregulated in multiple...
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Stress, inflammation, depression, and dementia associated with phosphate toxicity
Depression and dementia are predicted to increase within aging global populations. Pathophysiological effects of phosphate toxicity, dysregulated...
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Thymidine kinase 1 through the ages: a comprehensive review
Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and thymidine kinase 1 (TK1), have potential as diagnostic tools and...
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Heterophile Antibody to Adrenocorticotropin Hormone Interfering with the Investigation of Cushing’s Syndrome
The practice of medicine depends on the accuracy of biochemical assays. The high prevalence of incidental masses on imaging necessitates a correct...
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