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Crosstalk between adenine nucleotide transporter and mitochondrial swelling: experimental and computational approaches
Mitochondrial metabolism and function are modulated by changes in matrix Ca 2+ . Small increases in the matrix Ca 2+ stimulate mitochondrial...
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The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT)
Aging muscle experiences functional decline in part mediated by impaired mitochondrial ADP sensitivity. Elamipretide (ELAM) rapidly improves...
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Mutational analysis in Corynebacterium stationis MFS transporters for improving nucleotide bioproduction
AbstractProduct secretion from an engineered cell can be advantageous for microbial cell factories. Extensive work on nucleotide manufacturing, one...
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Enterococcus faecalis-derived adenine enhances enterohaemorrhagic Escherichia coli Type 3 Secretion System-dependent virulence
Interactions between microbiota and enteric pathogens can promote colonization resistance or enhance pathogenesis. The pathobiont Enterococcus faecalis ...
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NAD+ regulates nucleotide metabolism and genomic DNA replication
The intricate orchestration of enzymatic activities involving nicotinamide adenine dinucleotide (NAD + ) is essential for maintaining metabolic...
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Structures and mechanisms of the Arabidopsis cytokinin transporter AZG1
Cytokinins are essential for plant growth and development, and their tissue distributions are regulated by transmembrane transport. Recent studies...
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Caspase-dependent apoptosis in Riboflavin Transporter Deficiency iPSCs and derived motor neurons
Riboflavin Transporter Deficiency (RTD) is a rare genetic, childhood-onset disease. This pathology has a relevant neurological involvement, being...
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Nucleotide methylations in rRNA that confer resistance to ribosome-targeting antibiotics
Methylation of rRNA nucleotides is an effective means of conferring resistance to antibiotics that target the bacterial ribosome. This type of...
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Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4
Human multidrug resistance protein 4 (hMRP4, also known as ABCC4), with a representative topology of the MRP subfamily, translocates various...
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Cryo-EM structure and molecular mechanism of abscisic acid transporter ABCG25
Abscisic acid (ABA) is one of the plant hormones that regulate various physiological processes, including stomatal closure, seed germination and...
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Identification of a transcription factor, PunR, that regulates the purine and purine nucleoside transporter punC in E. coli
Many genes in bacterial genomes are of unknown function, often referred to as y-genes. Recently, the analytic methods have divided bacterial...
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Single-nucleotide editing for zebra3 and wsl5 phenotypes in rice using CRISPR/Cas9-mediated adenine base editors
The CRISPR/Cas9-mediated base editing technology can efficiently generate point mutations in the genome without introducing a double-strand break...
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Mitochondrial proton leak in cardiac aging
Age-associated diseases are becoming progressively more prevalent, reflecting the increased lifespan of the world’s population. However, the...
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Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells
Colorectal cancer (CRC) requires massive iron stores, but the complete mechanisms by which CRC modulates local iron handling are poorly understood....
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Structural basis for bacterial lipoprotein relocation by the transporter LolCDE
Lipoproteins in the outer membrane of Gram-negative bacteria are involved in various vital physiological activities, including multidrug resistance....
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Formate induces a metabolic switch in nucleotide and energy metabolism
Formate is a precursor for the de novo synthesis of purine and deoxythymidine nucleotides. Formate also interacts with energy metabolism by promoting...
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Genetic investigation of purine nucleotide imbalance in Saccharomyces cerevisiae
Because metabolism is a complex balanced process involving multiple enzymes, understanding how organisms compensate for transient or permanent...
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ATP-Binding Cassette Transporters: Snap-on Complexes?
ATP-binding cassette (ABC) transporters are one of the largest families of membrane proteins in prokaryotic organisms. Much is now understood about...
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Legume-potato rotation affects soil physicochemical properties, enzyme activity, and rhizosphere metabolism in continuous potato crop**
BackgroundContinuous crop** can reduce soil quality and affect rhizosphere metabolism, ultimately reducing crop yield. Crop rotation can mitigate...
