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Innate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors
Immune checkpoints (CTLA4 & PD-1) are inhibitory pathways that block aberrant immune activity and maintain self-tolerance. Tumors co-opt these...
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IL-1β-mediated adaptive reprogramming of endogenous human cardiac fibroblasts to cells with immune features during fibrotic remodeling
The source and roles of fibroblasts and T-cells during maladaptive remodeling and myocardial fibrosis in the setting of pulmonary arterial...
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Reversing the Aged Immune System with Stem Cells
The growing application for stem cells in medicine brings up the question of their role in aging and, to answer, how the information can be used to...
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Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications
The tumor microenvironment (TME) is a highly intricate milieu, comprising a multitude of components, including immune cells and stromal cells, that...
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Single-nucleus transcriptomics of epicardial adipose tissue from female pigs reveals effects of exercise training on resident innate and adaptive immune cells
BackgroundCoronary artery disease (CAD) is a leading cause of death in women. Epicardial adipose tissue (EAT) secretes cytokines to modulate coronary...
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The Effect of Photoperiod Duration on Humoral Innate and Humoral Adaptive Immune Responsiveness in Campbell’s Hamster
AbstractWe studied the humoral innate immune responsiveness (HII), i.e., the hemolysis of rabbit erythrocytes by complement proteins, the adaptive...
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Reversing the Aged Immune System with Stem Cells
The growing application for stem cells in medicine brings up the question of their role in aging and, to answer, how the information can be used to...
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Adaptive Immune Response Investigation in Lyme Borreliosis
To diagnose Lyme Borreliosis, it is advised to use an enzyme-linked immunosorbent test to check for serum antibodies specific for Lyme and all tests...
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Modulation of Mesenchymal Stem Cells-Mediated Adaptive Immune Effectors’ Repertoire in the Recovery of Systemic Lupus Erythematosus
The breakdown of self-tolerance of the immune response can lead to autoimmune conditions in which chronic inflammation induces tissue damage....
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Contribution of T- and B-cell intrinsic toll-like receptors to the adaptive immune response in viral infectious diseases
Toll-like receptors (TLRs) comprise a class of highly conserved molecules that recognize pathogen-associated molecular patterns and play a vital role...
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Intragraft immune cells: accomplices or antagonists of recipient-derived macrophages in allograft fibrosis?
Organ fibrosis caused by chronic allograft rejection is a major concern in the field of transplantation. Macrophage-to-myofibroblast transition plays...
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Polymorphisms in Innate and Adaptive Immune Genes in Subjects with Allergic Bronchopulmonary Aspergillosis Complicating Asthma
Innate and adaptive immunity play a crucial role in allergic bronchopulmonary aspergillosis (ABPA) pathogenesis. We performed next-generation...
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Dandelion uses the single-cell adaptive immune receptor repertoire to explore lymphocyte developmental origins
Assessment of single-cell gene expression (single-cell RNA sequencing) and adaptive immune receptor (AIR) sequencing (scVDJ-seq) has been invaluable...
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Immune targeting of HIV-1 reservoir cells: a path to elimination strategies and cure
Successful approaches for eradication or cure of HIV-1 infection are likely to include immunological mechanisms, but remarkably little is known about...
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Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19
Adenoviral and mRNA vaccines encoding the viral spike (S) protein have been deployed globally to contain severe acute respiratory syndrome...
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Tyndallized bacteria prime bronchial epithelial cells to mount an effective innate immune response against infections
Airway epithelium represents a physical barrier against toxic substances and pathogens but also presents pattern recognition receptors on the...
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Single-cell immune repertoire analysis
Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune cells that...
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The why and how of adaptive immune responses in ischemic cardiovascular disease
Atherosclerotic cardiovascular disease is a major cause of disability and death worldwide. Most therapeutic approaches target traditional risk...
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Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections
With the exception of an extremely small number of cases caused by single gene mutations, most autoimmune diseases result from the complex interplay...
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Gingival mesenchymal stem cell therapy, immune cells, and immunoinflammatory application
MSC-based therapeutic strategies have proven to be incredibly effective. Robust self-renewal, multilineage differentiation, and potential for tissue...
