Search
Search Results
-
Modeling Acute Myeloid Leukemia Using StarPEG-Heparin Hydrogels
Biomimetic semi-synthetic hydrogels formed from a combination of star-shaped poly(ethylene glycol) (starPEG) and the glycosaminoglycan, heparin,...
-
Emerging role of glutathione peroxidase 4 in myeloid cell lineage development and acute myeloid leukemia
Phospholipid Hydroperoxide Gluthatione Peroxidase also called Glutathione Peroxidase 4 is one of the 25 described human selenoproteins. It plays an...
-
Crosstalk between autophagy and metabolism: implications for cell survival in acute myeloid leukemia
Acute myeloid leukemia (AML), a prevalent form of leukemia in adults, is often characterized by low response rates to chemotherapy, high recurrence...
-
RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9
BackgroundThe oncogenic protein HOXA9 plays a critical role in leukemia transformation and maintenance, and its aberrant expression is a hallmark of...
-
A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia
Signal transducer and activator of transcription 3 (STAT3) is frequently overexpressed in patients with acute myeloid leukemia (AML). STAT3 exists in...
-
Invasive Aspergillosis in Patients with Acute Leukemia: Comparison Between Acute Myeloid and Acute Lymphoid Leukemia
BackgroundThe epidemiology of invasive aspergillosis (IA) in patients with acute lymphoid leukemia (ALL) has not been well characterized.
... -
Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes
Acute myeloid leukemia (AML) is a malignancy characterized by differentiation arrest of hematopoietic precursor cells. Differentiation therapy is...
-
Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia
Arginine methylation is catalyzed by protein arginine methyltransferases (PRMTs) and is involved in various cellular processes, including cancer...
-
SFXN3 is a Prognostic Marker and Promotes the Growth of Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a heterogeneous disease with rapid progression and frequent mutations. Sideroflexin3 (SFXN3) has been shown to be...
-
Macrophage migration inhibitory factor blockade reprograms macrophages and disrupts prosurvival signaling in acute myeloid leukemia
The malignant microenvironment plays a major role in the development of resistance to therapies and the occurrence of relapses in acute myeloid...
-
Targeting a lineage-specific PI3Kɣ–Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule
Dose-limiting toxicity poses a major limitation to the clinical utility of targeted cancer therapies, often arising from target engagement in...
-
Identifying key genes and functionally enriched pathways in acute myeloid leukemia by weighted gene co-expression network analysis
Acute myeloid leukemia (AML) is characterized by the uncontrolled proliferation of myeloid leukemia cells in the bone marrow and other hematopoietic...
-
Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation
Hematopoietic stem and progenitor cells (HSPCs) that have impaired differentiation can transform into leukemic blasts. However, the mechanism that...
-
Sox13 and M2-like leukemia-associated macrophages contribute to endogenous IL-34 caused accelerated progression of acute myeloid leukemia
Interleukin 34 (IL-34) mainly plays physiologic and pathologic roles through the sophisticated multi-ligand signaling system, macrophage...
-
Deep genomic characterization highlights complexities and prognostic markers of pediatric acute myeloid leukemia
Pediatric acute myeloid leukemia (AML) is an uncommon but aggressive hematological malignancy. The poor outcome is attributed to inadequate...
-
The epigenetic regulators EP300/CREBBP represent promising therapeutic targets in MLL-rearranged acute myeloid leukemia
Acute myeloid leukemia (AML) with mixed-lineage leukemia ( MLL ) gene rearrangements (MLL-r) is an aggressive subtype of blood cancer with dismal...
-
Oncogenic lncRNA FAM215A promotes the malignant cell phenotypes of acute myeloid leukemia (AML) cell lines
Acute myeloid leukemia (AML) is a form of blood cancer that arise as a result of clonal proliferation of malignant myeloid precursors acquiring...
-
Hyperactive Natural Killer cells in Rag2 knockout mice inhibit the development of acute myeloid leukemia
Immunotherapy has attracted considerable attention as a therapeutic strategy for cancers including acute myeloid leukemia (AML). In this study, we...
-
Ningetinib, a novel FLT3 inhibitor, overcomes secondary drug resistance in acute myeloid leukemia
BackgroundFMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is a common mutation type in acute myeloid leukemia (AML) and is usually...
-
Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia
Blocked cellular differentiation is a critical pathologic hallmark of acute myeloid leukemia (AML). Here, we showed that genetic activation of the...
