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Diagnostic efficacy of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 for early detection of acute kidney injury in dogs with leptospirosis or babesiosis
This study evaluates the diagnostic efficacy of urinary biomarkers, Neutrophil Gelatinase-Associated Lipocalin (uNGAL), and Kidney Injury Molecule-1...
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Mitochondrial metabolism and targeted treatment strategies in ischemic-induced acute kidney injury
Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI). The kidney is susceptible to IRI under several clinical conditions,...
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Scrub Typhus- An Underestimated Infectious Disease Attributable to Community Acquired Acute Kidney Injury
Acute Kidney Injury (AKI) associated with Scrub typhus is an emerging health problem which is more common in the tropics including India. This study...
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Investigating the role of itaconate in macrophage activation and oxidative stress injury in sepsis-associated acute kidney injury
BackgroundSepsis may be linked to oxidative stress and can be controlled by itaconate, an activator of the nuclear factor erythroid 2-related factor...
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DDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis
Acute kidney injury (AKI) constitutes a prevalent clinical syndrome characterized by elevated morbidity and mortality rates, emerging as a...
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Cellular senescence of renal tubular epithelial cells in acute kidney injury
Cellular senescence represents an irreversible state of cell-cycle arrest during which cells secrete senescence-associated secretory phenotypes,...
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DUSP1 protects against ischemic acute kidney injury through stabilizing mtDNA via interaction with JNK
The mechanism underlying acute kidney injury (AKI) and AKI-to-Chronic kidney disease (CKD) transition remains unclear, but mitochondrial dysfunction...
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β-hydroxybutyrate ameliorates sepsis-induced acute kidney injury
BackgroundSepsis is a major cause of acute kidney injury (AKI). Recent studies have demonstrated that β-hydroxybutyrate (β-HB) alleviates renal...
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Pyruvate kinase M2 regulates mitochondrial homeostasis in cisplatin-induced acute kidney injury
An important pathophysiological process of acute kidney injury (AKI) is mitochondrial fragmentation in renal tubular epithelial cells, which leads to...
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Crosstalk among proximal tubular cells, macrophages, and fibroblasts in acute kidney injury: single-cell profiling from the perspective of ferroptosis
The link between ferroptosis, a form of cell death mediated by iron and acute kidney injury (AKI) is recently gaining widespread attention. However,...
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The role of ferroptosis in acute kidney injury: mechanisms and potential therapeutic targets
Acute kidney injury (AKI) is one of the most common and severe clinical renal syndromes with high morbidity and mortality. Ferroptosis is a form of...
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Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53
Acute kidney injury (AKI) is a clinical syndrome with high morbidity and mortality but no specific therapy. Microsomal prostaglandin E synthase-2...
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Gasdermin D-deficient mice are hypersensitive to acute kidney injury
Signaling pathways of regulated necrosis, such as necroptosis and ferroptosis, contribute to acute kidney injury (AKI), but the role of pyroptosis is...
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Ulinastatin ameliorates podocyte ferroptosis via regulating miR-144-3p/SLC7A11 axis in acute kidney injury
Ferroptosis is a newly discovered form of cell death characterized by intracellular iron accumulation and subsequent lipid peroxidation, which has...
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Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury
BackgroundAcute kidney injury (AKI) is a common clinical disorder with complex etiology and poor prognosis, and currently lacks specific and...
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Subcutaneous injection of adipose stromal cell-secretome improves renal function and reduces inflammation in established acute kidney injury
BackgroundAdipose stromal cells (ASC) are a form of mesenchymal stromal cells that elicit effects primarily via secreted factors, which may have...
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Utility of Urinary Biomarkers for Diagnosis of Acute Kidney Injury (AKI) in COVID-19
Acute kidney injury (AKI) is a complication of COVID-19 and urinary biomarkers of renal “stress” and “injury” can be utilised for an early diagnosis....
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The emerging role of regulated cell death in ischemia and reperfusion-induced acute kidney injury: current evidence and future perspectives
Renal ischemia‒reperfusion injury (IRI) is one of the main causes of acute kidney injury (AKI), which is a potentially life-threatening condition...
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Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injury
Considering the high prevalence and the lack of targeted pharmacological management of acute kidney injury (AKI), the search for new therapeutic...
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Ammonium tetrathiomolybdate relieves oxidative stress in cisplatin-induced acute kidney injury via NRF2 signaling pathway
Cisplatin is an efficient chemotherapeutic agent for various solid tumors, but its usage is restricted by nephrotoxicity. A single dose of cisplatin...
